Research ArticleOriginal Research

Accuracy of Signs, Symptoms, and Hematologic Parameters for the Diagnosis of Infectious Mononucleosis: A Systematic Review and Meta-Analysis

Xinyan Cai, Mark H. Ebell and Lauren Haines
The Journal of the American Board of Family Medicine November 2021, 34 (6) 1141-1156; DOI: https://doi.org/10.3122/jabfm.2021.06.210217

References

  1. 1.↵
    1. Henke CE,
    2. Kurland LT,
    3. Elveback LR
    . Infectious mononucleosis in Rochester, Minnesota, 1950 through 1969. Am J Epidemiol 1973;98:483–90.
    OpenUrlPubMedWeb of Science
  2. 2.↵
    1. Ebell MH,
    2. Call M,
    3. Shinholser J,
    4. Gardner J
    . Does this patient have infectious mononucleosis?: the rational clinical examination systematic review diagnosing infectious mononucleosis diagnosing infectious mononucleosis. Jama 2016;315:1502–9.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Rea TD,
    2. Russo JE,
    3. Katon W,
    4. Ashley RL,
    5. Buchwald DS
    . Prospective study of the natural history of infectious mononucleosis caused by Epstein-Barr virus. J Am Board Fam Pract 2001;14:234–42.
    OpenUrlAbstract
  4. 4.↵
    1. Hoagland RJ
    . The clinical manifestations of infectious mononucleosis. a report of two hundred cases. American Journal of Medical Sciences 1960;240:21–9.
    OpenUrl
  5. 5.↵
    1. Aronson MD,
    2. Komaroff AL,
    3. Pass TM,
    4. Ervin CT,
    5. Branch WT
    . Heterophil antibody in adults with sore throat: frequency and clinical presentation. Ann Intern Med 1982;96:505–8.
    OpenUrlPubMedWeb of Science
  6. 6.↵
    1. Grotto I,
    2. Mimouni D,
    3. Huerta M,
    4. et al
    . Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults. Epidemiol Infect 2003;131:683–9.
    OpenUrlCrossRefPubMedWeb of Science
  7. 7.↵
    1. Rice L,
    2. Jung M
    . Neutrophilic leukocytosis, neutropenia, monocytosis, and monocytopenia. In: Hematology. Elsevier; 2018:675–81.
  8. 8.↵
    1. Brigden ML,
    2. Au S,
    3. Thompson S,
    4. Brigden S,
    5. Doyle P,
    6. Tsaparas Y
    . Infectious mononucleosis in an outpatient population: diagnostic utility of 2 automated hematology analyzers and the sensitivity and specificity of Hoagland's criteria in heterophile-positive patients. Arch Pathol Lab Med 1999;123:875–81.
    OpenUrlPubMedWeb of Science
  9. 9.↵
    1. Biggs TC,
    2. Hayes SM,
    3. Bird JH,
    4. Harries PG,
    5. Salib RJ
    . Use of the lymphocyte count as a diagnostic screen in adults with suspected Epstein-Barr virus infectious mononucleosis. Laryngoscope 2013;123:2401–4.
    OpenUrl
  10. 10.↵
    1. Hutton B,
    2. Salanti G,
    3. Caldwell DM,
    4. et al
    . The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 2015;162:777–84.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Whiting PF,
    2. Rutjes AW,
    3. Westwood ME
    , QUADAS-2 Group, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 2011;155:529–36.
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.↵
    1. Deeks JJ,
    2. Bossuyt PM,
    3. Gatsonis C
    1. Reitsma J,
    2. Rutjes A,
    3. Whiting P,
    4. Vlassov V,
    5. Leeflang M
    . Assessing methodological quality. In: Deeks JJ, Bossuyt PM, Gatsonis C (editors), Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy Version 1.0. 0. The Cochrane Collaboration, 2009. Available from: http://srdtacochrane.org/. 2009.
  13. 13.↵
    1. Doebler P,
    2. Holling H
    . Meta-Analysis of Diagnostic Accuracy the mada: R package version 0.5.8. 2017.
  14. 14.↵
    1. Team RC
    . R: A language and environment for statistical computing. R Foundation for Statistical Computing. 2013. [Database]
  15. 15.↵
    1. Metz CE
    . Basic principles of ROC analysis. Semin Nucl Med 1978;8:283–98.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. Balfour HH Jr..,
    2. Holman CJ,
    3. Hokanson KM,
    4. et al
    . A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis. J Infect Dis 2005;192:1505–12.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Sumaya CV,
    2. Ench Y
    . Epstein-Barr virus infectious mononucleosis in children. I. Clinical and general laboratory findings. Pediatrics 1985;75:1003–10.
    OpenUrlAbstract/FREE Full Text
  18. 18.↵
    1. Ventura KC,
    2. Hudnall SD
    . Hematologic differences in heterophile-positive and heterophile-negative infectious mononucleosis. Am J Hematol 2004;76:315–8.
    OpenUrlPubMed
  19. 19.↵
    1. Ginsburg CM,
    2. Henle W,
    3. Henle G,
    4. Horwitz CA
    . Infectious mononucleosis in children. Evaluation of Epstein-Barr virus-specific serological data. Jama 1977;237:781–5.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.↵
    1. Fleisher G,
    2. Collins M,
    3. Fager S
    . Limitations of available tests for diagnosis of infectious mononucleosis. J Clin Microbiol 1983;17:619–24.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Chretien J,
    2. Esswein J,
    3. Holland W,
    4. McCauley C
    . Predictors of the duration of infectious mononucleosis. South Med J 1977;70:437–9.
    OpenUrlPubMedWeb of Science
  22. 22.↵
    1. Hossain A
    . Infectious mononucleosis and mononucleosis-like illnesses in children and adults in Saudi Arabia. J Trop Pediatr 1989;35:121–5.
    OpenUrlCrossRefPubMed
  23. 23.↵
    1. Llor C,
    2. Hernández M,
    3. Hernández S,
    4. Martínez T,
    5. Gómez FF
    . Validity of a point-of-care based on heterophile antibody detection for the diagnosis of infectious mononucleosis in primary care. Eur J Gen Pract 2012;18:15–21.
    OpenUrlPubMed
  24. 24.↵
    1. Krabbe S,
    2. Hesse J,
    3. Uldall P
    . Primary Epstein-Barr virus infection in early childhood. Arch Dis Child 1981;56:49–52.
    OpenUrlAbstract/FREE Full Text
  25. 25.↵
    1. Ho-Yen D,
    2. Martin KW
    . The relationship between atypical lymphocytosis and serological tests in infectious mononucleosis. J Infect 1981;3:324–31.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Gartzonika C,
    2. Vrioni G,
    3. Priavali E,
    4. Pappas G,
    5. Levidiotou S
    . Utility of real-time PCR in the diagnosis of primary Epstein-Barr virus infection. J Med Microb Diagn 2012;02:2161-0703.1000118.
  27. 27.↵
    1. Lennon P,
    2. O' Neill JP,
    3. Fenton JE,
    4. O' Dwyer T
    . Challenging the use of the lymphocyte to white cell count ratio in the diagnosis of infectious mononucleosis by analysis of a large cohort of Monospot test results. Clin Otolaryngol 2010;35:397–401.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Schooley R
    . Epstein-Barr virus infections, including infectious mononucleosis. Harrison's Principles of Internal Medicine 1987;699–703.
  29. 29.↵
    1. Horwitz CA,
    2. Henle W,
    3. Henle G,
    4. et al
    . Clinical and laboratory evaluation of elderly patients with heterophil-antibody positive infectious mononucleosis: Report of seven patients, ages 40 to 78. Am J Med 1976;61:333–9.
    OpenUrlCrossRefPubMedWeb of Science
  30. 30.↵
    1. Carter JW,
    2. Edson RS,
    3. Kennedy CC
    . Infectious mononucleosis in the older patient. Mayo Clinic Proc 1978;53(3):146–50.
    OpenUrlPubMedWeb of Science
  31. 31.↵
    1. Del CM,
    2. Pincus D
    . Incidence patterns of respiratory illness in Queensland estimated from sentinel general practice. Aust Fam Physician 1995;24:625–9.
    OpenUrlPubMed
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