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Brief ReportBrief Report

Excess Factor VIII: A Common Cause of Hypercoagulability

Robert S. Bobrow
The Journal of the American Board of Family Practice March 2005, 18 (2) 147-149; DOI: https://doi.org/10.3122/jabfm.18.2.147
Robert S. Bobrow
MD
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    Table 1.

    Coagulation Work-up

    Patient 1Patient 2Patient 3Reference Range
    Age/sex40/M63/F45/M
    Presenting problemPE*PE/DVTDVT
    Platelets143,000273,000236,000
    Factor V Leiden mutationNPNPNP
    Prothrombin gene mutationNPNPNP
    Activated protein S1297611682% to 151%
    Activated protein C7811†7265% to 122%
    Antithrombin III activity711126685% to 130%
    Antithrombin III antigen280215191 to 369 mg/L
    Anti-cardiolipin IgG61018<15: − 15 to 20: ±
    Anti-cardiolipin IgM131511<12.5: − 12.5 to 20: ±
    Lupus anticoagulant screen ratio1.361.50<1.20
    Protein S antigen (total)1446515372% to 152%
    Protein C antigen81606176% to 158%
    Factor X antigen529870% to 140%
    Homocysteine10.911.9
    Factor IX66
    Factor VIII (done twice)27623924750% to 150%‡
    126§221329
    • * PE, pulmonary emboli; DVT, deep vein thrombosis; NP, not present.

    • † Believed to be secondary to concomitant warfarin.

    • ‡ Percentage (%) is the same as international units/deciliter (IU/dL).

    • § Performed at a different laboratory; all others done by Stony Brook University Hospital Laboratory.

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The Journal of the American Board of Family Practice: 18 (2)
The Journal of the American Board of Family Practice
Vol. 18, Issue 2
1 Mar 2005
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Excess Factor VIII: A Common Cause of Hypercoagulability
Robert S. Bobrow
The Journal of the American Board of Family Practice Mar 2005, 18 (2) 147-149; DOI: 10.3122/jabfm.18.2.147

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Excess Factor VIII: A Common Cause of Hypercoagulability
Robert S. Bobrow
The Journal of the American Board of Family Practice Mar 2005, 18 (2) 147-149; DOI: 10.3122/jabfm.18.2.147
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