RT Journal Article
SR Electronic
T1 Excess Factor VIII: A Common Cause of Hypercoagulability
JF The Journal of the American Board of Family Practice
JO J Am Board Fam Med
FD American Board of Family Medicine
SP 147
OP 149
DO 10.3122/jabfm.18.2.147
VO 18
IS 2
A1 Robert S. Bobrow
YR 2005
UL http://www.jabfm.org/content/18/2/147.abstract
AB Background: Elevations of coagulation factor VIII have recently been described in significant numbers of patients with venous thromboembolism (VTE) previously thought to have had an “idiopathic” event. Three patients from a family practice are presented with recurrent VTE and increased factor VIII levels.Method: The case histories and results of laboratory tests were reviewed.Results: The 3 patients had no other clear coagulopathy. In 2 of the 3, the increase was confirmed with a second reading.Conclusions: Factor VIII assay should be considered in the work-up of idiopathic, recurrent VTE. Long-term anticoagulation may be appropriate in this setting.