PT  - JOURNAL ARTICLE
AU  - Robert S. Bobrow
TI  - Excess Factor VIII: A Common Cause of Hypercoagulability
AID  - 10.3122/jabfm.18.2.147
DP  - 2005 Mar 01
TA  - The Journal of the American Board of Family Practice
PG  - 147--149
VI  - 18
IP  - 2
4099  - http://www.jabfm.org/content/18/2/147.short
4100  - http://www.jabfm.org/content/18/2/147.full
SO  - J Am Board Fam Med2005 Mar 01; 18
AB  - Background: Elevations of coagulation factor VIII have recently been described in significant numbers of patients with venous thromboembolism (VTE) previously thought to have had an “idiopathic” event. Three patients from a family practice are presented with recurrent VTE and increased factor VIII levels.Method: The case histories and results of laboratory tests were reviewed.Results: The 3 patients had no other clear coagulopathy. In 2 of the 3, the increase was confirmed with a second reading.Conclusions: Factor VIII assay should be considered in the work-up of idiopathic, recurrent VTE. Long-term anticoagulation may be appropriate in this setting.