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Research ArticleOriginal Research

A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19

Corey Fogleman, Donna Cohen, Alison Mercier, Daniel Farrell, Jennifer Rutz, Kellie Bresz and Tawnya Vernon
The Journal of the American Board of Family Medicine July 2022, 35 (4) 695-707; DOI: https://doi.org/10.3122/jabfm.2022.04.210529
Corey Fogleman
From Penn Medicine/Lancaster General Health Family Medicine Residency Program: (CF, DC, AM, DF, JR); Penn Medicine/Lancaster General Health Research Institute: (KB, TV).
MD, FAAFP
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Donna Cohen
From Penn Medicine/Lancaster General Health Family Medicine Residency Program: (CF, DC, AM, DF, JR); Penn Medicine/Lancaster General Health Research Institute: (KB, TV).
MD, MSc
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Alison Mercier
From Penn Medicine/Lancaster General Health Family Medicine Residency Program: (CF, DC, AM, DF, JR); Penn Medicine/Lancaster General Health Research Institute: (KB, TV).
MD
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Daniel Farrell
From Penn Medicine/Lancaster General Health Family Medicine Residency Program: (CF, DC, AM, DF, JR); Penn Medicine/Lancaster General Health Research Institute: (KB, TV).
MD
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Jennifer Rutz
From Penn Medicine/Lancaster General Health Family Medicine Residency Program: (CF, DC, AM, DF, JR); Penn Medicine/Lancaster General Health Research Institute: (KB, TV).
MD
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Kellie Bresz
From Penn Medicine/Lancaster General Health Family Medicine Residency Program: (CF, DC, AM, DF, JR); Penn Medicine/Lancaster General Health Research Institute: (KB, TV).
MS
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Tawnya Vernon
From Penn Medicine/Lancaster General Health Family Medicine Residency Program: (CF, DC, AM, DF, JR); Penn Medicine/Lancaster General Health Research Institute: (KB, TV).
MPH
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References

  1. 1.↵
    1. Ye Q,
    2. Wang B,
    3. Mao J
    . The Pathogenesis and Treatment of the ‘Cytokine Storm’ in COVID-19. J Infect 2020;80:607–13.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Jovic TH,
    2. Ali SR,
    3. Ibrahim N,
    4. et al
    . Could Vitamins Help in the Fight Against COVID-19? Nutrients 2020;12:2550. Published 2020 Aug 23.
    OpenUrl
  3. 3.↵
    1. Zhang R,
    2. Wang X,
    3. Ni L,
    4. et al
    . COVID-19: Melatonin as a potential adjuvant treatment. Life Sci 2020;250:117583.
    OpenUrlPubMed
  4. 4.↵
    1. Brown GM,
    2. Pandi-Perumal SR,
    3. Pupko H,
    4. Kennedy JL,
    5. Cardinali DP
    . Melatonin as an Add-On Treatment of COVID-19 Infection: Current Status. Diseases 2021 Sep 20;9:64.
    OpenUrl
  5. 5.↵
    1. Cai Y,
    2. Li Y-F,
    3. Tang L-P,
    4. et al
    . A New Mechanism of Vitamin C Effects on A/FM/1/47(H1N1) Virus-Induced Pneumonia in Restraint-Stressed Mice. Biomed Res Int 2015;2015:675149.
    OpenUrl
  6. 6.↵
    1. Kashiouris MG,
    2. L'Heureux M,
    3. Cable CA,
    4. Fisher BJ,
    5. Leichtle SW,
    6. Fowler AA
    . The Emerging Role of Vitamin C as a Treatment for Sepsis. Nutrients 2020;12:292. Published 2020 Jan 22.
    OpenUrlCrossRef
  7. 7.↵
    1. Hemilä H,
    2. Chalker E
    , Cochrane Acute Respiratory Infections Group. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2013;2013:. Issue Art. No.: CD000980. Available at: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000980.pub4/full.
  8. 8.↵
    1. Hemilä H,
    2. Chalker E,
    3. Douglas B
    . Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007;Issue Art. No.: CD0000980. Available at: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD000980.pub3/information.
  9. 9.↵
    1. Alamdari DH,
    2. Moghaddam AB,
    3. Amini S,
    4. et al
    . Application of methylene blue-vitamin C–N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial. Eur J Pharmacol 2020;885:173494.
    OpenUrl
  10. 10.↵
    1. Hiedra R,
    2. Lo KB,
    3. Elbashabsheh M,
    4. et al
    . The use of IV vitamin C for patients with COVID-19: A case series. Expert Rev. Anti-Infect. Ther 2020;1.
  11. 11.↵
    1. Öztürk G,
    2. Akbulut KG,
    3. Güney Ş
    . Melatonin, aging, and COVID-19: Could melatonin be beneficial for COVID-19 treatment in the elderly? Turk J Med Sci 2020;50:1504–12.Oct 22.
    OpenUrl
  12. 12.↵
    1. Hardeland R
    . Melatonin and inflammation – Story of a Double-Edged Blade. J Pineal Res 2018;65:e12525
    OpenUrlPubMed
  13. 13.↵
    1. Silvestri M,
    2. Rossi GA
    . Melatonin: its possible role in the management of viral infections – a brief review. Ital J Pediatr 2013;39:61.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Farnoosh G,
    2. Akbariqomi M,
    3. Badri T,
    4. et al
    . Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial. Arch Med Res 2021;Jun 23:S0188-4409(21)00141-7. Epub ahead of print.
  15. 15.↵
    1. Mousavi SA,
    2. Heydari K,
    3. Mehravaran H,
    4. et al
    . Melatonin effects on sleep quality and outcomes of COVID-19 patients: An open-label, randomized, controlled trial. J Med Virol 2022;94:263–71.
    OpenUrl
  16. 16.↵
    1. Cross KM,
    2. Landis DM,
    3. Sehgal L,
    4. Payne JD
    . Melatonin for the Early Treatment of COVID-19: A Narrative Review of Current Evidence and Possible Efficacy. Endocr Pract 2021;27:850–5.Aug. Epub 2021 Jun 10.
    OpenUrl
  17. 17.↵
    1. Brown GM,
    2. Pandi-Perumal SR,
    3. Pupko H,
    4. Kennedy JL,
    5. Cardinali DP
    . Melatonin as an Add-On Treatment of COVID-19 Infection: Current Status. Diseases (Basel, Switzerland 2021;9:64).
    OpenUrl
  18. 18.↵
    1. Barrett B,
    2. Brown R,
    3. Mundt M,
    4. et al
    . The Wisconsin Upper Respiratory Symptom Survey is responsive, reliable, and valid. J Clin Epidemiol 2005;58:609–17.
    OpenUrlCrossRefPubMedWeb of Science
  19. 19.↵
    1. Barrett B,
    2. Brown RE,
    3. Mundt MP,
    4. et al
    . Validation of a short form Wisconsin Upper Respiratory Symptom Survey (WURSS-21). Health Qual Life Outcomes 2009;7:76.
    OpenUrlCrossRefPubMed
  20. 20.↵
    Wisconsin Upper Respiratory Symptom Survey 21 —Daily Symptom Report. Available from: https://www.fammed.wisc.edu/files/webfm-uploads/documents/research/wurss-21.pdf Accessed last on Dec 16, 2021.
  21. 21.↵
    Symptoms of COVID-19. Centers for Disease Control and Prevention. Available from: https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html#self-checker Accessed last on Dec 16, 2021.
  22. 22.↵
    1. Thomas S,
    2. Patel D,
    3. Bittel B,
    4. et al
    . Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open 2021;4:e210369 Feb 1.
    OpenUrl
  23. 23.↵
    1. JamaliMoghadamSiahkali S,
    2. Zarezade B,
    3. Koolaji S,
    4. et al
    . Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial. Eur J Med Res 2021;26:20. Published 2021 Feb 11.
    OpenUrl
  24. 24.↵
    1. Rawat D,
    2. Roy A,
    3. Maitra S,
    4. Gulati A,
    5. Khanna P,
    6. Baidya DK
    . Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials. Diabetes Metab Syndr 2021;15:102324.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. Zhou Y,
    2. Hou Y,
    3. Shen J,
    4. et al
    . A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PLoS Biol 2020;18:e3000970.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Ramlall V,
    2. Zucker J,
    3. Tatonetti N
    . Melatonin is significantly associated with survival of intubated COVID-19 patients. medRxiv 2020; [Epub ahead of print: 18 Oct 2020]. Available at: http://www.ncbi.nlm.nih.gov/pubmed/33083812.
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The Journal of the American Board of Family     Medicine: 35 (4)
The Journal of the American Board of Family Medicine
Vol. 35, Issue 4
July/August 2022
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A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19
Corey Fogleman, Donna Cohen, Alison Mercier, Daniel Farrell, Jennifer Rutz, Kellie Bresz, Tawnya Vernon
The Journal of the American Board of Family Medicine Jul 2022, 35 (4) 695-707; DOI: 10.3122/jabfm.2022.04.210529

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A Pilot of a Randomized Control Trial of Melatonin and Vitamin C for Mild-to-Moderate COVID-19
Corey Fogleman, Donna Cohen, Alison Mercier, Daniel Farrell, Jennifer Rutz, Kellie Bresz, Tawnya Vernon
The Journal of the American Board of Family Medicine Jul 2022, 35 (4) 695-707; DOI: 10.3122/jabfm.2022.04.210529
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Keywords

  • Ascorbic Acid
  • COVID-19
  • Dietary Supplements
  • Double-Blind Method
  • Melatonin
  • Quality of Life
  • Regression Analysis
  • Vitamin C
  • Vitamins
  • WURSS

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