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Research ArticleResearch Letter

Methotrexate Toxicity from Unintentional Dosing Errors: Calls to a Poison Center and Death Descriptions

John A. Thompson, Jennifer S. Love and Robert G. Hendrickson
The Journal of the American Board of Family Medicine November 2021, 34 (6) 1246-1248; DOI: https://doi.org/10.3122/jabfm.2021.06.210120
John A. Thompson
From Oregon Poison Center, Portland, OR (JAT, JSL, RGH); Department of Emergency Medicine, Oregon Health & Science University, Portland (JAT, JSL, RGH).
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Jennifer S. Love
From Oregon Poison Center, Portland, OR (JAT, JSL, RGH); Department of Emergency Medicine, Oregon Health & Science University, Portland (JAT, JSL, RGH).
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Robert G. Hendrickson
From Oregon Poison Center, Portland, OR (JAT, JSL, RGH); Department of Emergency Medicine, Oregon Health & Science University, Portland (JAT, JSL, RGH).
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    Table 1.

    Characteristics of Methotrexate Ingestions by Humans

    CharacteristicNumber%
    Total calls of ingestions111100
    Sex
        Male3229
        Female7971
    Age (years)
        0 to 181514
        19 to 401514
        41 to 603431
        61 to 803632
        81 to 10087
        Not listed/unknown33
    Ingestion type
        Intentional2321
        Unintentional8879
    Unintentional subtype
        Dose error1315
        One extra dose4045
        Multiple extra doses2731
        Pediatric exploratory89
        Medication indication listed6962
        Rheumatoid arthritis3855
        Crohn's disease57
        Psoriasis or psoriatic arthritis1420
        Other disease1217
    Treatment
        Leucovorin treatment34
        Intentional ingestion1235
        Unintentional ingestion2265
        Sodium bicarbonate18
        Activated charcoal6
        Blood products4
        Steroids1
        Granulocyte stimulating factor2
    Course
        Ingestions admitted to hospital41
        Intentional ingestion1741
        Unintentional—dose error25
        Unintentional—one extra dose1127
        Unintentional—multiple extra doses820
        Unintentional—ediatric exploratory37
        Admitted and leucovorin treatment3128
        Intentional ingestion1239
        Unintentional ingestion1961
        Recorded signs of toxicity1211
        Death22
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The Journal of the American Board of Family   Medicine: 34 (6)
The Journal of the American Board of Family Medicine
Vol. 34, Issue 6
November/December 2021
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Methotrexate Toxicity from Unintentional Dosing Errors: Calls to a Poison Center and Death Descriptions
John A. Thompson, Jennifer S. Love, Robert G. Hendrickson
The Journal of the American Board of Family Medicine Nov 2021, 34 (6) 1246-1248; DOI: 10.3122/jabfm.2021.06.210120

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Methotrexate Toxicity from Unintentional Dosing Errors: Calls to a Poison Center and Death Descriptions
John A. Thompson, Jennifer S. Love, Robert G. Hendrickson
The Journal of the American Board of Family Medicine Nov 2021, 34 (6) 1246-1248; DOI: 10.3122/jabfm.2021.06.210120
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Keywords

  • Drug-Related Side Effects and Adverse Reactions
  • Leucovorin
  • Medical Errors
  • Methotrexate
  • Poison Center
  • Retrospective Studies

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