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Research ArticleOriginal Research

Glucosamine/Chondroitin and Mortality in a US NHANES Cohort

Dana E. King and Jun Xiang
The Journal of the American Board of Family Medicine November 2020, 33 (6) 842-847; DOI: https://doi.org/10.3122/jabfm.2020.06.200110
Dana E. King
From the Department of Family Medicine, West Virginia University, Morgantown.
MD, MS
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Jun Xiang
From the Department of Family Medicine, West Virginia University, Morgantown.
MS, MA
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  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
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References

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    National Institutes of Health, National Center for Complementary and Integrative Health. Glucosamine and Chondroitin for Osteoarthritis. September 2017. Available at: https://nccih.nih.gov/health/glucosaminechondroitin#hed1. Accessed March 16, 2020.
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    . Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial. JAMA 2010;304:45–52.
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    . The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum 2008;58:3183–91.
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    1. Sawitzke AD,
    2. Shi H,
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    5. Harris CL,
    6. Singer NG,
    7. et al
    . Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis 2010;69:1459–64.
    OpenUrlAbstract/FREE Full Text
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    1. Reginster JY,
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    3. Rovati LC,
    4. Lee RL,
    5. Lejeune E,
    6. Bruyere O,
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    . Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 2001;357:251–6.
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    1. Ma H,
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    5. Ley SH,
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    7. et al
    . Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank. BMJ 2019;365:l1628.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Bell GA,
    2. Kantor ED,
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    . Use of glucosamine and chondroitin in relation to mortality. Eur J Epidemiol 2012;27:593–603.
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    1. Navarro SL,
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    7. et al
    . Randomized trial of glucosamine chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans. PLoS One 2015;10:e0117534.
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    1. Yu Z,
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    . Anti-lung cancer effect of glucosamine by suppressing the phosphorylation of FOXO. Mol Med Rep 2017;16:3395–400.
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    1. Hu J,
    2. Chen H,
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    . Augmented O-GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast-induced acute kidney injury in rats. Free Radic Biol Med 2017;103:121–32.
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    . Arterial smooth muscle cell proteoglycans synthesized in the presence of glucosamine demonstrate reduced binding to LDL. J Lipid Res 2002;43:149–57.
    OpenUrlAbstract/FREE Full Text
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The Journal of the American Board of Family     Medicine: 33 (6)
The Journal of the American Board of Family Medicine
Vol. 33, Issue 6
November-December 2020
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Glucosamine/Chondroitin and Mortality in a US NHANES Cohort
Dana E. King, Jun Xiang
The Journal of the American Board of Family Medicine Nov 2020, 33 (6) 842-847; DOI: 10.3122/jabfm.2020.06.200110

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Glucosamine/Chondroitin and Mortality in a US NHANES Cohort
Dana E. King, Jun Xiang
The Journal of the American Board of Family Medicine Nov 2020, 33 (6) 842-847; DOI: 10.3122/jabfm.2020.06.200110
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Keywords

  • Cardiovascular Diseases
  • Chondroitin
  • Cohort Studies
  • Glucosamine
  • Nutrition Surveys
  • Osteoarthritis
  • Proportional Hazards Models

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