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Research ArticleOriginal Research

Depression Screening Rates and Symptom Severity by Alcohol Use Among Primary Care Adult Patients

Matthew E. Hirschtritt, Andrea H. Kline-Simon, Kurt Kroenke and Stacy A. Sterling
The Journal of the American Board of Family Medicine September 2018, 31 (5) 724-732; DOI: https://doi.org/10.3122/jabfm.2018.05.180092
Matthew E. Hirschtritt
From Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA (MEH); Division of Research, Kaiser Permanente Northern California, Oakland (AHK-S, SAS); Indiana University School of Medicine, Regenstrief Institute, Inc., Indianapolis, IN (KK).
MD, MPH
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Andrea H. Kline-Simon
From Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA (MEH); Division of Research, Kaiser Permanente Northern California, Oakland (AHK-S, SAS); Indiana University School of Medicine, Regenstrief Institute, Inc., Indianapolis, IN (KK).
MS
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Kurt Kroenke
From Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA (MEH); Division of Research, Kaiser Permanente Northern California, Oakland (AHK-S, SAS); Indiana University School of Medicine, Regenstrief Institute, Inc., Indianapolis, IN (KK).
MD
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Stacy A. Sterling
From Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA (MEH); Division of Research, Kaiser Permanente Northern California, Oakland (AHK-S, SAS); Indiana University School of Medicine, Regenstrief Institute, Inc., Indianapolis, IN (KK).
DrPH, MPH, MSW
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Article Figures & Data

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    Table 1.

    Demographic and Clinical Characteristics by Depression Screening Status among Primary Care Adult Patients Screened for Hazardous Alcohol Use

    CharacteristicNo. (%)P valueNo. (%)P value
    Administered the PHQ-9Not Administered the PHQ-9Met Criteria for Significant DepressionDid Not Meet Criteria for Significant Depression
    Totals(n = 68,686)*(n = 2,826,220)*(n = 32,390)†(n = 36,296)†
    Sex<.001<.001
        Female45,007 (65.5)1,505,142 (53.3)21,715 (67.0)23,292 (64.2)
        Male23,679 (34.5)1,321,078 (46.7)10,675 (33.0)13,004 (35.8)
    Age, years<.001<.001
        18 to 3932,295 (47.0)1,081,490 (38.3)17,017 (52.5)15,278 (42.1)
        40 to 6527,980 (40.8)1,213,142 (42.9)12,546 (38.7)15,434 (42.5)
        >658,411 (12.2)531,588 (18.8)2,827 (8.7)5,584 (15.4)
    Race/ethnicity‡<.001<.001
        Asian6,619 (9.6)525,505 (18.6)3,169 (9.8)3,450 (9.5)
        Black/African American4,348 (6.3)200,530 (7.1)2,525 (7.8)1,823 (5.0)
        Hispanic14,194 (20.7)554,523 (19.6)7,425 (22.9)6,769 (18.7)
        White39,035 (56.8)1,351,540 (47.8)17,013 (52.5)22,022 (60.7)
        Other/Unknown4,490 (6.5)194,122 (6.9)2,258 (7.0)2,232 (6.2)
    Medicaid coverage<.001<.001
        Yes1,066 (1.6)29,347 (1.0)632 (2.0)434 (1.2)
        No67,620 (98.4)2,796,873 (99.0)31,758 (98.0)35,862 (98.8)
    Nondepressive/non-SUD mental health diagnosis§<.001.751
        Yes4,628 (6.7)138,773 (4.9)2,172 (6.7)2,456 (6.8)
        No64,058 (93.3)2,687,447 (95.1)30,218 (93.3)33,840 (93.2)
    Charlson comorbidity score, mean (SD)0.29 (0.95)0.41 (1.15)<.0010.27 (0.91)0.31 (0.98)<.001
    Weekly alcohol use ‖<.001<.001
        Abstinent45,468 (66.2)1,949,582 (69.0)22,069 (68.1)23,399 (64.5)
        Moderate alcohol use**19,189 (27.9)764,294 (27.0)8,275 (25.6)10,914 (30.1)
        Hazardous alcohol use††4,029 (5.9)112,344 (4.0)2,046 (6.3)1,983 (5.5)
    • PHQ-9, Patient Health Questionnaire 9; SUD, substance use disorder; ICD-9, International Classification of Diseases, ninth revision; SD, standard deviation.

    • ↵* Data were restricted to the first PHQ-9 administration within 30 days following the first Alcohol Drinking as a Vital Sign primary care visit within the study period.

    • ↵† Among patients who were administered the PHQ-9 (n = 68,686).

    • ↵‡ Race/ethnicity data were self-reported by patients during their intake evaluation.

    • ↵§ Any ICD-9 visit diagnosis code within 1 year prior to the first Alcohol Drinking as a Vital Sign primary care visit that adhered to the following criteria was considered a positive diagnosis: any mental, behavioral and neurodevelopmental disorder (290.XX, 293.XX, 294.XX-302.9, or 306.XX-319), excluding depressive disorders (296.2X, 296.3X, 296.82, 298.0, 300.4, 301.12, 309.0, 309.1, 309.28, or 311), alcohol-related mental disorders (291.XX, 305.0X, or 303.0X), drug-induced mental disorders (292.XX), and nontobacco drug abuse or dependence (305.2X, 305.3X, 305.4X, 305.5X, 306.6X, 305.7X, 305.8X, 305.9X, or 304.XX), where “X” represents any positive integer.

    • ↵‖ Patients were asked to estimate alcohol use within the past 90 days.

    • ↵** 1 to 7 drinks/week for all woman and men ages >65 years and 1 to 14 drinks/week for men ≤65 years.

    • ↵†† ≥8 drinks/week for all woman and men ages >65 years and ≥15 drinks/week for men ≤65 years.

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    Table 2.

    Adjusted Odds Ratios of Depression Screening Administration and Significant Depression among Primary Care Adult Patients Screened for Hazardous Alcohol Use*

    CharacteristicOR (95% CI)P valueOR (95% CI)P value
    Administered the PHQ-9Significant Depressive Symptoms†
    Female (reference group, male)1.67 (1.59 to 1.75)<.0011.11 (1.06 to 1.17)<.001
    Age, years (reference group, 18 to 39)
        40 to 650.77 (0.73 to 0.81)<.0010.75 (0.72 to 0.78)<.001
        >650.51 (0.45 to 0.57)<.0010.47 (0.43 to 0.51)<.001
    Race/ethnicity (reference group, White)‡
        Asian0.45 (0.42 to 0.48)<.0011.07 (0.98 to 1.16).113
        Black/African American0.75 (0.69 to 0.80)<.0011.55 (1.38 to 1.75)<.001
        Hispanic0.82 (0.78 to 0.87)<.0011.29 (1.20 to 1.40)<.001
        Other/Unknown0.78 (0.75 to 0.81)<.0011.21 (1.13 to 1.30)<.001
    Medicaid coverage1.25 (1.15 to 1.36)<.0011.31 (1.15 to 1.48)<.001
    Nondepressive/non-SUD mental health diagnosis§1.32 (1.26 to 1.39)<.0010.96 (0.90 to 1.03).310
    Charlson comorbidity score‖0.96 (0.94 to 0.98)<.0011.03 (1.01 to 1.06).003
    Weekly alcohol use (reference group: hazardous alcohol use)**
        Abstinent0.72 (0.67 to 0.77)<.0010.84 (0.78 to 0.90)<.001
        Moderate alcohol use††0.70 (0.67 to 0.74)<.0010.71 (0.66 to 0.76)<.001
    • CI, confidence interval; OR, odds ratio; PHQ-9, Patient Health Questionnaire 9; SUD, substance use disorder; ICD-9, International Classification of Diseases, ninth revision.

    • ↵* Logistic generalized estimating equations accounting for patient nested within facility were applied to estimate population-level average effects.

    • ↵† Among patients who were administered the PHQ-9 (n = 68,686).

    • ↵‡ Race/ethnicity data were self-reported by patients during their intake evaluation.

    • ↵§ Any ICD-9 visit diagnosis code within 1 year prior to the first Alcohol Drinking as a Vital Sign primary care visit that adhered to the following criteria was considered a positive diagnosis: any mental, behavioral and neurodevelopmental disorder (290.XX, 293.XX, 294.XX-302.9, or 306.XX-319), excluding depressive disorders (296.2X, 296.3X, 296.82, 298.0, 300.4, 301.12, 309.0, 309.1, 309.28, or 311), alcohol-related mental disorders (291.XX, 305.0X, or 303.0X), drug-induced mental disorders (292.XX), and nontobacco drug abuse or dependence (305.2X, 305.3X, 305.4X, 305.5X, 306.6X, 305.7X, 305.8X, 305.9X, or 304.XX), where “X” represents any positive integer.

    • ↵‖ ORs correspond to a 1-point increment in the Charlson comorbidity score.

    • ↵** Patients were asked to estimate alcohol use within the past 90 days; hazardous alcohol use was defined as ≥8 drinks/week for all woman and men ages >65 years and ≥15 drinks/week for men ≤65 years.

    • ↵†† 1 to 7 drinks/week for all woman and men ages >65 years and 1 to 14 drinks/week for men ≤65 years.

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The Journal of the American Board of Family     Medicine: 31 (5)
The Journal of the American Board of Family Medicine
Vol. 31, Issue 5
September-October 2018
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Depression Screening Rates and Symptom Severity by Alcohol Use Among Primary Care Adult Patients
Matthew E. Hirschtritt, Andrea H. Kline-Simon, Kurt Kroenke, Stacy A. Sterling
The Journal of the American Board of Family Medicine Sep 2018, 31 (5) 724-732; DOI: 10.3122/jabfm.2018.05.180092

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Depression Screening Rates and Symptom Severity by Alcohol Use Among Primary Care Adult Patients
Matthew E. Hirschtritt, Andrea H. Kline-Simon, Kurt Kroenke, Stacy A. Sterling
The Journal of the American Board of Family Medicine Sep 2018, 31 (5) 724-732; DOI: 10.3122/jabfm.2018.05.180092
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