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Brief ReportBrief Report

Renal Failure in a Soldier Taking N.O.-Xplode

Kelly A. Siano
The Journal of the American Board of Family Medicine July 2014, 27 (4) 565-569; DOI: https://doi.org/10.3122/jabfm.2014.04.130113
Kelly A. Siano
From the Department of Family Medicine, Tripler Army Medical Center, Honolulu, HI.
MD, CPT
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References

  1. 1.↵
    1. Gahche J,
    2. Bailey R,
    3. Burt V,
    4. et al
    . Dietary supplement use among U.S. adults has increased since NHANES III (1998–1994). NCHS Data Brief, number 61, April 2011. Atlanta: Centers for Disease Control and Prevention; 2011. Available from: http://www.cdc.gov/nchs/data/databriefs/db61.htm. Accessed March 23, 2014.
  2. 2.↵
    Dietary Supplement Health and Education Act of 1994. Silver Spring, MD: US Food and Drug Administration; 1994 [updated May 20, 2009]. Available from: http://www.fda.gov/regulatoryinformation/legislation/federalfooddrugandcosmeticactfdcact/significantamendmentstothefdcact/ucm148003.htm. Accessed March 23, 2014.
  3. 3.↵
    1. Tarn DM,
    2. Paterniti DA,
    3. Good JS,
    4. et al
    . Physician-patient communication about dietary supplements. Patient Educ Couns 2013;91:287–94.
    OpenUrlPubMed
  4. 4.↵
    1. Ashar BH,
    2. Rowland-Seymour A
    . Advising patients who use dietary supplements. Am J Med 2008;121:91–7.
    OpenUrlPubMed
  5. 5.↵
    1. Ashar BH,
    2. Rice TN,
    3. Sisson SD
    . Physicians understanding of the regulation of dietary supplements. Arch Intern Med 2007;167:966–9.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Martin DJ,
    2. Partridge BJ,
    3. Shields W
    . Hepatotoxicity associated with the dietary supplement N.O.-Xplode. Ann Intern Med 2013;159:503–4.
    OpenUrlPubMed
  7. 7.↵
    1. Magee CD,
    2. Moawad FJ,
    3. Moses F
    . NO-Xplode: a case of supplement-associated ischemic colitis. Mil Med 2010;175:202–5.
    OpenUrlPubMed
  8. 8.↵
    1. Prosser JM,
    2. Majlesi N,
    3. Chan GM,
    4. Olsen D,
    5. Hoffman RS,
    6. Nelson LS
    . Adverse effects associated with arginine α-ketoglutarate containing supplements. Hum Exp Toxicol 2009;28:259–62.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Dellamea BS,
    2. Leitao CB,
    3. Friedman R,
    4. Canani LH
    . Nitric oxide system and diabetic nephropathy. Diabetol Metab Syndr 2014;6:17.
    OpenUrlPubMed
  10. 10.↵
    1. Lahera V,
    2. Salom MG,
    3. Miranda-Guardiola F,
    4. Moncada S,
    5. Romero JC
    . Effects of NG-nitro-L-arginine methyl ester on renal function and blood pressure. Am J Phyisol. 1991;261(6 Pt 2):F1033–7.
    OpenUrlPubMedWeb of Science
  11. 11.↵
    1. Terjung RL,
    2. Clarkson P,
    3. Eichner ER,
    4. et al
    . American College of Sports Medicine roundtable: the physiological and health effects of oral creatine supplementation. Med Sci Sports Exerc 2000;32:706–17.
    OpenUrlPubMedWeb of Science
  12. 12.↵
    1. Armentano MJ,
    2. Brenner AK,
    3. Hedman TL,
    4. et al
    . The effect and safety of short-term creatine supplementation on performance of push-ups. Mil Med 2007;172:312–7.
    OpenUrlPubMed
  13. 13.↵
    1. Mihic S,
    2. MacDonald JR,
    3. McKenzie S,
    4. Tarnopolsky MA
    . Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291–6.
    OpenUrlPubMedWeb of Science
  14. 14.↵
    1. Poortmans JR,
    2. Auguier H,
    3. Renaut V,
    4. Durussel A,
    5. Saugy M,
    6. Brisson GR
    . Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol Occup Physiol 1997;76:566–7.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Groeneveld GJ,
    2. Beijer C,
    3. Veldink JH,
    4. Kalmijn S,
    5. Wokke JH,
    6. van den Berg LH
    . Few adverse effects of long-term creatine supplementation in a placebo controlled trial. Int J Sports Med 2005;26:307–13.
    OpenUrlPubMed
  16. 16.↵
    1. Gualano B,
    2. Ugrinowitsch C,
    3. Novaes RB,
    4. et al
    . Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Eur J Appl Physiol 2008;103:33–40.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Kreider RB,
    2. Melton C,
    3. Rasmussen CJ,
    4. et al
    . Long-term creatine supplementation does not significantly affect clinical markers of health in athletes. Mol Cell Biochem 2003;244:95–104.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Mayhew DL,
    2. Mayhew JL,
    3. Ware JS
    . Effects of long-term creatine supplementation on liver and kidney function in American college football players. Int J Sports Nutr Exerc Metab 2002;12:453–60.
    OpenUrlPubMedWeb of Science
  19. 19.↵
    1. Poortmans JR,
    2. Francaux M
    . Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108–10.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.↵
    1. Koshy KM,
    2. Griswold E,
    3. Schneeberger EE
    . Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814–5.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    1. Thorsteinsdottir B,
    2. Grande JP,
    3. Garovic VD
    . Acute renal failure in a young weight lifter taking multiple food supplements, including creatine monohydrate. J Ren Nutr 2006;16:341–5.
    OpenUrlCrossRefPubMedWeb of Science
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The Journal of the American Board of Family     Medicine: 27 (4)
The Journal of the American Board of Family Medicine
Vol. 27, Issue 4
July-August 2014
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Renal Failure in a Soldier Taking N.O.-Xplode
Kelly A. Siano
The Journal of the American Board of Family Medicine Jul 2014, 27 (4) 565-569; DOI: 10.3122/jabfm.2014.04.130113

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Renal Failure in a Soldier Taking N.O.-Xplode
Kelly A. Siano
The Journal of the American Board of Family Medicine Jul 2014, 27 (4) 565-569; DOI: 10.3122/jabfm.2014.04.130113
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