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Brief ReportBrief Report

Renal Failure in a Soldier Taking N.O.-Xplode

Kelly A. Siano
The Journal of the American Board of Family Medicine July 2014, 27 (4) 565-569; DOI: https://doi.org/10.3122/jabfm.2014.04.130113
Kelly A. Siano
From the Department of Family Medicine, Tripler Army Medical Center, Honolulu, HI.
MD, CPT
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    Figure 1.

    Contents label of N.O.-Xplode, a dietary supplement manufactured by Bio-Engineered Supplements and Nutrition. The amount of each ingredient within the N.O.-Xplode Proprietary Blend are not provided. The patient described in this case was previously healthy but developed severe renal failure while taking N.O.-Xplode.

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    Table 1. Comparison of Patient Characteristics and Disease Courses Among Cases Describing an Association Between Creatine Supplementation and Renal Failure
    Patient CharacteristicsCase 1*Case 2†Case 3‡
    Age (years)202426
    SexMaleMaleMale
    Creatine dosage20 g daily for 4 weeks5 g 3 times per week for 6 monthsUnknown daily dose for 3 months
    Presenting symptomsNausea, vomiting, flank pain, abdominal tendernessLeft flank tenderness, abdominal pain, polydipsia, polyuriaNausea, flank pain, abdominal pain and tenderness
    Peak blood pressure (mmHg)160/100152/100182/94
    Peak creatinine (mg/dL)2.35.410.64
    Lowest eGFR36.413.15.9
    Renal biopsy resultsAIN and ATN with normal glomeruliAIN with normal glomeruliATN with normal glomeruli
    • ↵* Described by Koshy et al.20

    • ↵† Described by Thorsteinsdottir et al.21

    • ↵‡ Patient described in this review.

    • AIN, acute interstitial nephritis; ATN, acute tubular necrosis; eGFR, estimate glomerular filtration rate.

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The Journal of the American Board of Family     Medicine: 27 (4)
The Journal of the American Board of Family Medicine
Vol. 27, Issue 4
July-August 2014
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Renal Failure in a Soldier Taking N.O.-Xplode
Kelly A. Siano
The Journal of the American Board of Family Medicine Jul 2014, 27 (4) 565-569; DOI: 10.3122/jabfm.2014.04.130113

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Renal Failure in a Soldier Taking N.O.-Xplode
Kelly A. Siano
The Journal of the American Board of Family Medicine Jul 2014, 27 (4) 565-569; DOI: 10.3122/jabfm.2014.04.130113
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