Skip to main content

Main menu

  • HOME
  • ARTICLES
    • Current Issue
    • Abstracts In Press
    • Archives
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • Other Publications
    • abfm

User menu

Search

  • Advanced search
American Board of Family Medicine
  • Other Publications
    • abfm
American Board of Family Medicine

American Board of Family Medicine

Advanced Search

  • HOME
  • ARTICLES
    • Current Issue
    • Abstracts In Press
    • Archives
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • JABFM on Bluesky
  • JABFM On Facebook
  • JABFM On Twitter
  • JABFM On YouTube
Review ArticleClinical Review

Identification and Basic Management of Bleeding Disorders in Adults

Rebecca Kruse-Jarres, Tammuella C. Singleton and Cindy A. Leissinger
The Journal of the American Board of Family Medicine July 2014, 27 (4) 549-564; DOI: https://doi.org/10.3122/jabfm.2014.04.130227
Rebecca Kruse-Jarres
From the Department of Medicine (RKJ, CAL), and the Department of Pediatrics (TCS), Tulane University School of Medicine, New Orleans, Louisiana.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tammuella C. Singleton
From the Department of Medicine (RKJ, CAL), and the Department of Pediatrics (TCS), Tulane University School of Medicine, New Orleans, Louisiana.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cindy A. Leissinger
From the Department of Medicine (RKJ, CAL), and the Department of Pediatrics (TCS), Tulane University School of Medicine, New Orleans, Louisiana.
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Acharya SS,
    2. Coughlin A,
    3. Dimichele DM
    . Rare Bleeding Disorder Registry: deficiencies of factors II, V, VII, X, XIII, fibrinogen and dysfibrinogenemias. J Thromb Haemost 2004;2:248–56.
    OpenUrlCrossRefPubMedWeb of Science
  2. 2.↵
    1. Wahlberg T,
    2. Blombäck M,
    3. Hall P,
    4. Axelsson G
    . Application of indicators, predictors and diagnostic indices in coagulation disorders. I. Evaluation of a self-administered questionnaire with binary questions. Methods Inf Med 1980;19:194–200.
    OpenUrlPubMedWeb of Science
  3. 3.↵
    1. Hassan AA,
    2. Kroll MH
    . Acquired disorders of platelet function. Hematology Am Soc Hematol Educ Program 2005:403–408.
  4. 4.↵
    1. Sadler JE,
    2. Rodeghiero F
    , ISTH SSC Subcommittee on von Willebrand Factor. Provisional criteria for the diagnosis of VWD type 1. J Thromb Haemost 2005;3:775–7.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Rodeghiero F,
    2. Tosetto A,
    3. Abshire T,
    4. et al
    . ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders. J Thromb Haemost 2010;8:2063–5.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Tosetto A,
    2. Castaman G,
    3. Plug I,
    4. Rodeghiero F,
    5. Eikenboom J
    . Prospective evaluation of the clinical utility of quantitative bleeding severity assessment in patients referred for hemostatic evaluation. J Thromb Haemost 2011;9:1143–8.
    OpenUrlCrossRefPubMed
  7. 7.↵
    ACOG Committee on Practice Bulletins—Gynecology. American College of Obstetricians and Gynecologists. ACOG practice bulletin: management of anovulatory bleeding. Int J Gynaecol Obstet 2001;72:263–71.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Bolton-Maggs PH,
    2. Chalmers EA,
    3. Collins PW,
    4. et al
    . A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. Br J Haematol 2006;135:603–33.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Girolami A,
    2. Ruzzon E,
    3. Tezza F,
    4. Scandellari R,
    5. Vettore S,
    6. Girolami B
    . Arterial and venous thrombosis in rare congenital bleeding disorders: a critical review. Haemophilia 2006;12:345–51.
    OpenUrlCrossRefPubMedWeb of Science
  10. 10.↵
    1. Inbal A,
    2. Muszbek L
    . Coagulation factor deficiencies and pregnancy loss. Semin Thromb Hemost 2003;29:171–4.
    OpenUrlCrossRefPubMedWeb of Science
  11. 11.↵
    1. Warner PE,
    2. Critchley HO,
    3. Lumsden MA,
    4. Campbell-Brown M,
    5. Douglas A,
    6. Murray GD
    . Menorrhagia I: measured blood loss, clinical features, and outcome in women with heavy periods: a survey with follow-up data. Am J Obstet Gynecol 2004;190:1216–23.
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.↵
    1. Romney G,
    2. Glick M
    . An updated concept of coagulation with clinical implications. J Am Dent Assoc 2009;140:567–74.
    OpenUrlAbstract/FREE Full Text
  13. 13.↵
    1. van Herrewegen F,
    2. Meijers JC,
    3. Peters M,
    4. van Ommen CH
    . Clinical practice: the bleeding child. Part II: disorders of secondary hemostasis and fibrinolysis. Eur J Pediatr 2012;171:201–14.
    OpenUrl
  14. 14.↵
    1. Van Ommen CH,
    2. Peters M
    . The bleeding child. Part I: primary hemostatic disorders. Eur J Pediatr 2012;171:1–10.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Cattaneo M
    . Inherited platelet-based bleeding disorders. J Thromb Haemost 2003;1:1628–36.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. Cines DB,
    2. Bussel JB,
    3. McMillan RB,
    4. Zehnder JL
    . Congenital and acquired thrombocytopenia. Hematology Am Soc Hematol Educ Program 2005:390–406.
  17. 17.↵
    1. Balduini CL,
    2. Pecci A,
    3. Noris P
    . Inherited thrombocytopenias. The evolving spectrum. Hamostaseologie 2012;32:259–70.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Noris P,
    2. Pecci A,
    3. Di Bari F,
    4. et al
    . Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients. Haematologica 2004;89:1219–25.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Balduini CL,
    2. Cattaneo M,
    3. Fabris F,
    4. et al
    . Inherited thrombocytopenias: a proposed diagnostic algorithm from the Italian Gruppo di Studio delle Piastrine. Haematologica 2003;88:582–92.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Konkle BA
    . Acquired disorders of platelet function. Hematology Am Soc Hematol Educ Program 2011:391–6.
  21. 21.↵
    1. Coppola A,
    2. Di Minno G
    . Desmopressin in inherited disorders of platelet function. Haemophilia 2008;14(Suppl 1):31–9.
    OpenUrlPubMed
  22. 22.↵
    1. Tuohy E,
    2. Litt E,
    3. Alikhan R
    . Treatment of patients with von Willebrand disease. J Blood Med 2011;2:49–57.
    OpenUrlPubMed
  23. 23.↵
    1. Nichols WL,
    2. Hultin MB,
    3. James AH,
    4. et al
    . von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia 2008;14:171–232.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.↵
    1. Lee CA,
    2. Chi C,
    3. Pavord SR,
    4. et al
    . The obstetric and gynaecological management of women with inherited bleeding disorders–review with guidelines produced by a taskforce of UK Haemophilia Centre Doctors' Organization. Haemophilia 2006;12:301–36.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. James AH,
    2. Kouides PA,
    3. Abdul-Kadir R,
    4. et al
    . Evaluation and management of acute menorrhagia in women with and without underlying bleeding disorders: consensus from an international expert panel. Eur J Obstet Gynecol Reprod Biol 2011;158:124–34.
    OpenUrlCrossRefPubMed
  26. 26.↵
    1. Holland L,
    2. Sarode R
    . Should plasma be transfused prophylactically before invasive procedures? Curr Opin Hematol 2006;13:447–51.
    OpenUrlCrossRefPubMedWeb of Science
  27. 27.↵
    1. Bushick JB,
    2. Eisenberg JM,
    3. Kinman J,
    4. Cebul RD,
    5. Schwartz JS
    . Pursuit of abnormal coagulation screening tests generates modest hidden preoperative costs. J Gen Intern Med 1989;4:493–7.
    OpenUrlPubMed
  28. 28.↵
    1. Hayward CP,
    2. Moffat KA,
    3. Liu Y
    . Laboratory investigations for bleeding disorders. Semin Thromb Hemost 2012;38:742–52.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Kamal AH,
    2. Tefferi A,
    3. Pruthi RK
    . How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults. Mayo Clin Proc 2007;82:864–73.
    OpenUrlCrossRefPubMedWeb of Science
  30. 30.↵
    1. Green D
    . Interpreting coagulation assays. Blood Coagul Fibrinolysis. 2010;21(Suppl 1):S3–6.
    OpenUrlPubMed
  31. 31.↵
    1. Jones DW,
    2. Gallimore MJ,
    3. Mackie IJ,
    4. Harris SL,
    5. Winter M
    . Reduced factor XII levels in patients with the antiphospholipid syndrome are associated with antibodies to factor XII. Br J Haematol 2000;110:721–6.
    OpenUrlCrossRefPubMedWeb of Science
  32. 32.↵
    1. Mazodier K,
    2. Arnaud L,
    3. Mathian A,
    4. et al
    . Lupus anticoagulant-hypoprothrombinemia syndrome: report of 8 cases and review of the literature. Medicine (Baltimore) 2012;91:251–60.
    OpenUrlCrossRefPubMedWeb of Science
  33. 33.↵
    1. Franchini M,
    2. Lippi G
    . Acquired factor VIII inhibitors. Blood 2008;112:250–5.
    OpenUrlAbstract/FREE Full Text
  34. 34.↵
    1. Knoebl P,
    2. Marco P,
    3. Baudo F,
    4. et al
    . Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). J Thromb Haemost 2012;10:622–31.
    OpenUrlCrossRefPubMed
  35. 35.↵
    1. Collins P,
    2. Baudo F,
    3. Huth-Kuhne A,
    4. et al
    . Consensus recommendations for the diagnosis and treatment of acquired hemophilia A. BMC Res Notes 2010;3:161.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Huth-Kuhne A,
    2. Baudo F,
    3. Collins P,
    4. et al
    . International recommendations on the diagnosis and treatment of patients with acquired hemophilia A. Haematologica 2009;94:566–75.
    OpenUrlAbstract/FREE Full Text
  37. 37.↵
    1. Tay L,
    2. Duncan E,
    3. Singhal D,
    4. et al
    . Twelve years of experience of acquired hemophilia A: trials and tribulations in South Australia. Semin Thromb Hemost 2009;35:769–77.
    OpenUrlCrossRefPubMed
  38. 38.↵
    1. Zeitler H,
    2. Ulrich-Merzenich G,
    3. Goldmann G,
    4. Vidovic N,
    5. Brackmann HH,
    6. Oldenburg J
    . The relevance of the bleeding severity in the treatment of acquired haemophilia - an update of a single-centre experience with 67 patients. Haemophilia 2010;16:95–101.
    OpenUrlPubMed
  39. 39.↵
    1. Hay CRM,
    2. Negrier C,
    3. Ludlam CA
    . The treatment of bleeding in acquired haemophilia with recombinant factor VIIa: a multicentre study. Thromb Haemost 1997;78:1463–7.
    OpenUrlPubMedWeb of Science
  40. 40.↵
    1. Morrison AE,
    2. Ludlam CA,
    3. Kessler C
    . Use of porcine factor VIII in the treatment of patients with acquired hemophilia. Blood 1993;81:1513–20.
    OpenUrlAbstract/FREE Full Text
  41. 41.↵
    1. Sekhon SS,
    2. Roy V
    . Thrombocytopenia in adults: a practical approach to evaluation and management. South Med J 2006;99:491–8.
    OpenUrlCrossRefPubMed
  42. 42.↵
    1. Drews RE
    . Critical issues in hematology: anemia, thrombocytopenia, coagulopathy, and blood product transfusions in critically ill patients. Clin Chest Med 2003;24:607–22.
    OpenUrlCrossRefPubMedWeb of Science
  43. 43.↵
    1. McCrae KR
    . Thrombocytopenia in pregnancy. Hematology Am Soc Hematol Educ Program 2010:397–402.
  44. 44.↵
    1. Abildgaard U,
    2. Heimdal K
    . Pathogenesis of the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP): a review. Eur J Obstet Gynecol Reprod Biol 2013;166:117–23.
    OpenUrlCrossRefPubMed
  45. 45.↵
    1. Drews RE,
    2. Weinberger SE
    . Thrombocytopenic disorders in critically ill patients. Am J Respir Crit Care Med 2000;162(2 Pt 1):347–51.
    OpenUrlCrossRefPubMedWeb of Science
  46. 46.↵
    1. Mannucci PM,
    2. Peyvandi F
    . TTP and ADAMTS13: when is testing appropriate? Hematology Am Soc Hematol Educ Program 2007:121–6.
  47. 47.↵
    1. Stasi R,
    2. Amadori S,
    3. Osborn J,
    4. Newland AC,
    5. Provan D
    . Long-term outcome of otherwise healthy individuals with incidentally discovered borderline thrombocytopenia. PLoS Med 2006;3:e24.
    OpenUrlCrossRefPubMed
  48. 48.↵
    1. Simon TL,
    2. Snyder EL,
    3. Stowell CP,
    4. Strauss RG,
    5. Solheim BG,
    6. Petrides M
    1. Arnold DM,
    2. Smith JW,
    3. Warkentin TE
    . Management of immune thrombocytopenia. In: Simon TL, Snyder EL, Stowell CP, Strauss RG, Solheim BG, Petrides M , eds. Rossi's principles of transfusion medicine. 4th ed. Oxford, UK: Blackwell Publishing Ltd; 2009. p. 344–75.
  49. 49.↵
    1. Peterson P,
    2. Hayes TE,
    3. Arkin CF,
    4. et al
    . The preoperative bleeding time test lacks clinical benefit: College of American Pathologists' and American Society of Clinical Pathologists' position article. Arch Surg 1998;133:134–9.
    OpenUrlCrossRefPubMedWeb of Science
  50. 50.↵
    1. Castaman G,
    2. Tosetto A,
    3. Goodeve A,
    4. et al
    . The impact of bleeding history, von Willebrand factor and PFA-100(®) on the diagnosis of type 1 von Willebrand disease: results from the European study MCMDM-1VWD. Br J Haematol 2010;151:245–51.
    OpenUrlCrossRefPubMed
  51. 51.↵
    1. Sladky JL,
    2. Klima J,
    3. Grooms L,
    4. Kerlin BA,
    5. O'Brien SH
    . The PFA-100® does not predict delta-granule platelet storage pool deficiencies. Haemophilia 2012;18:626–9.
    OpenUrlCrossRefPubMed
  52. 52.↵
    1. Akin M,
    2. Polat Y
    . Platelet function analyser (PFA)-100(®) closure time in the evaluation of non-steroidal anti-inflammatory drug-induced platelet dysfunction in children with bleeding symptoms. Blood Transfus 2012;10:545–6.
    OpenUrlPubMed
  53. 53.↵
    1. Jámbor C,
    2. von Pape KW,
    3. Spannagl M,
    4. Dietrich W,
    5. Giebl A,
    6. Weisser H
    . Multiple electrode whole blood aggregometry, PFA-100, and in vivo bleeding time for the point-of-care assessment of aspirin-induced platelet dysfunction in the preoperative setting. Anesth Analg 2011;113:31–9.
    OpenUrlCrossRefPubMed
  54. 54.↵
    1. Sokkary NA,
    2. Venkateswaran L,
    3. Dietrich JE,
    4. Teruya J
    . Platelet function disorders and menorrhagia in adolescents: a review of laboratory diagnosis. J Pediatri Adolesc Gynecol 2012;25:233–7.
    OpenUrl
  55. 55.↵
    1. Favaloro EJ
    . The utility of the PFA-100 in the identification of von Willebrand disease: a concise review. Semin Thromb Hemost 2006;32:537–45.
    OpenUrlCrossRefPubMedWeb of Science
  56. 56.↵
    1. Brown DL
    . Congenital bleeding disorders. Curr Probl Pediatr Adolesc Health Care 2005;35:38–62.
    OpenUrlCrossRefPubMed
  57. 57.↵
    1. Carpenter SL,
    2. Mathew P
    . Alpha2-antiplasmin and its deficiency: fibrinolysis out of balance. Haemophilia 2008;14:1250–4.
    OpenUrlCrossRefPubMedWeb of Science
  58. 58.↵
    1. Jackson SC,
    2. Odiaman L,
    3. Card RT,
    4. van der Bom JG,
    5. Poon MC
    . Suspected collagen disorders in the bleeding disorder clinic: a case-control study. Haemophilia 2013;19:246–50.
    OpenUrlPubMed
  59. 59.↵
    1. Karimi M,
    2. Bereczky Z,
    3. Cohan N,
    4. Muszbek L
    . Factor XIII deficiency. Semin Thromb Hemost 2009;35:426–38.
    OpenUrlCrossRefPubMed
  60. 60.↵
    1. Mehta R,
    2. Shapiro AD
    . Plasminogen activator inhibitor type 1 deficiency. Haemophilia 2008;14:1255–60.
    OpenUrlCrossRefPubMedWeb of Science
  61. 61.↵
    1. Daniele F,
    2. Rossi V,
    3. Santoro C
    . Effective management of intracranial haemorrhage with continuous infusion of highly purified von Willebrand factor/factor VIII complex concentrate in an adult with severe haemophilia A. Blood Transfus 2011;9:472–4.
    OpenUrlPubMed
  62. 62.↵
    1. Kalsi H,
    2. Nanayakkara L,
    3. Pasi KJ,
    4. Bowles L,
    5. Hart DP
    . Access to primary dental care for patients with inherited bleeding disorders. Haemophilia 2012;18:510–5.
    OpenUrlPubMed
  63. 63.↵
    1. Kumar JN,
    2. Kumar RA,
    3. Varadarajan R,
    4. Sharma N
    . Specialty dentistry for the hemophiliac: is there a protocol in place? Indian J Dent Res 2007;18:48–54.
    OpenUrlCrossRefPubMed
  64. 64.↵
    1. Fogarty PF,
    2. Kouides P
    . How we treat: patients with haemophilia undergoing screening colonoscopy. Haemophilia 2010;16:363–5.
    OpenUrlPubMed
  65. 65.↵
    1. Brewer A,
    2. Correa ME
    . Guidelines for dental treatment of patients with inherited bleeding disorders. Montreal, Quebec, Canada: World Federation of Hemophilia Dental Committee; 2006. Available from: http://www1.wfh.org/publication/files/pdf-1190.pdf. Accessed May 16, 2014.
  66. 66.↵
    1. Hewson I,
    2. Makhmalbaf P,
    3. Street A,
    4. McCarthy P,
    5. Walsh M
    . Dental surgery with minimal factor support in the inherited bleeding disorder population at the Alfred Hospital. Haemophilia 2011;17:e185–8.
    OpenUrlPubMed
  67. 67.↵
    1. Lee AP,
    2. Boyle CA,
    3. Savidge GF,
    4. Fiske J
    . Effectiveness in controlling haemorrhage after dental scaling in people with haemophilia by using tranexamic acid mouthwash. Br Dent J 2005;198:33–8, discussion 26.
    OpenUrlCrossRefPubMed
  68. 68.↵
    1. Seligsohn U
    . Treatment of inherited platelet disorders. Haemophilia 2012;18(Suppl 4):161–5.
    OpenUrlCrossRefPubMed
  69. 69.↵
    1. Liumbruno G,
    2. Bennardello F,
    3. Lattanzio A,
    4. Piccoli P,
    5. Rossetti G
    ; Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Work Group. Recommendations for the transfusion of plasma and platelets. Blood Transfus 2009;7:132–50.
    OpenUrlPubMed
  70. 70.↵
    British Committee for Standards in Haematology, Blood Transfusion Task Force. Guidelines for the use of platelet transfusions. Br J Haematol 2003;122:10–23.
    OpenUrlCrossRefPubMedWeb of Science
  71. 71.↵
    1. Lisman T,
    2. Porte RJ
    . Rebalanced hemostasis in patients with liver disease: evidence and clinical consequences. Blood 2010;116:878–85.
    OpenUrlAbstract/FREE Full Text
  72. 72.↵
    1. O'Shaughnessy DF,
    2. Atterbury C,
    3. Bolton Maggs P,
    4. et al
    . Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant. Br J Haematol 2004;126:11–28.
    OpenUrlCrossRefPubMedWeb of Science
  73. 73.↵
    1. Peyvandi F,
    2. Palla R,
    3. Menegatti M,
    4. Mannucci PM
    . Introduction. Rare bleeding disorders: general aspects of clinical features, diagnosis, and management. Semin Thromb Hemost 2009;35:349–55.
    OpenUrlCrossRefPubMed
  74. 74.↵
    1. Rodgers GM
    . Prothrombin complex concentrates in emergency bleeding disorders. Am J Hematol 2012;87:898–902.
    OpenUrlCrossRefPubMed
  75. 75.↵
    United Kingdom Haemophilia Centre Doctors' Organisation. Guidelines on the selection and use of therapeutic products to treat haemophilia and other hereditary bleeding disorders. Haemophilia 2003;9:1–23.
    OpenUrlPubMed
  76. 76.↵
    1. Bolton-Maggs PH,
    2. Perry DJ,
    3. Chalmers EA,
    4. et al
    . The rare coagulation disorders–review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation. Haemophilia 2004;10:593–628.
    OpenUrlCrossRefPubMedWeb of Science
  77. 77.↵
    1. Baudo F,
    2. Collins P,
    3. Huth-Kühne A,
    4. et al
    . Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry. Blood 2012;120:39–46.
    OpenUrlAbstract/FREE Full Text
  78. 78.↵
    1. De Bels D,
    2. Demeere JL,
    3. Dugauqier J,
    4. Louis P,
    5. Van der Vorst E
    . Continuous infusion of factor VIIIc during heart surgery in a patient with haemophilia A. Eur J Anaesthesiol 2004;21:984–6.
    OpenUrlPubMed
  79. 79.↵
    1. Ker K,
    2. Edwards P,
    3. Perel P,
    4. Shakur H,
    5. Roberts I
    . Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012;344:e3054.
    OpenUrlAbstract/FREE Full Text
  80. 80.↵
    1. Kouides PA,
    2. Byams VR,
    3. Philipp CS,
    4. et al
    . Multisite management study of menorrhagia with abnormal laboratory haemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid. Br J Haematol 2009;145:212–20.
    OpenUrlCrossRefPubMedWeb of Science
  81. 81.↵
    1. Krakow EF,
    2. Walker I,
    3. Lamy A,
    4. Anderson JA
    . Cardiac surgery in patients with haemophilia B: a case report and review of the literature. Haemophilia 2009;15:108–13.
    OpenUrlCrossRefPubMedWeb of Science
  82. 82.↵
    1. Lin PC,
    2. Hsu CH,
    3. Huang CC,
    4. Chen WS,
    5. Wang JW
    . The blood-saving effect of tranexamic acid in minimally invasive total knee replacement: is an additional pre-operative injection effective? J Bone Joint Surg Br 2012;94:932–6.
    OpenUrlPubMed
  83. 83.↵
    1. Nurden AT,
    2. Freson K,
    3. Seligsohn U
    . Inherited platelet disorders. Haemophilia 2012;18(Suppl 4):154–60.
    OpenUrlCrossRefPubMed
  84. 84.↵
    1. Tang M,
    2. Wierup P,
    3. Terp K,
    4. Ingerslev J,
    5. Sorensen B
    . Cardiac surgery in patients with haemophilia. Haemophilia 2009;15:101–7.
    OpenUrlCrossRefPubMedWeb of Science
  85. 85.↵
    1. Venkateswaran L,
    2. Yee DL
    . Rare bleeding disorders in young women. J Pediatr Adolesc Gynecol 2010;23(6 Suppl):S38–42.
    OpenUrlCrossRefPubMed
  86. 86.↵
    1. Yang ZG,
    2. Chen WP,
    3. Wu LD
    . Effectiveness and safety of tranexamic acid in reducing blood loss in total knee arthroplasty: a meta-analysis. J Bone Joint Surg Br 2012;94:1153–9.
    OpenUrl
  87. 87.↵
    1. Dunn AL,
    2. Cox Gill J
    . Adenotonsillectomy in patients with desmopressin responsive mild bleeding disorders: a review of the literature. Haemophilia 2010;16:711–6.
    OpenUrlCrossRefPubMedWeb of Science
  88. 88.↵
    1. Hedges SJ,
    2. Dehoney SB,
    3. Hooper JS,
    4. Amanzadeh J,
    5. Busti AJ
    . Evidence-based treatment recommendations for uremic bleeding. Nat Clin Pract Nephrol 2007;3:138–53.
    OpenUrlCrossRefPubMedWeb of Science
  89. 89.↵
    1. Mannucci PM
    . Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years. Blood 1997;90:2515–21.
    OpenUrlFREE Full Text
  90. 90.↵
    1. Mannucci PM
    . How I treat patients with von Willebrand disease. Blood 2001;97:1915–9.
    OpenUrlAbstract/FREE Full Text
  91. 91.↵
    1. Sanders S,
    2. Purcell S,
    3. Silva M,
    4. Palerme S,
    5. James P
    . Relationship between diagnosis and intervention in women with inherited bleeding disorders and menorrhagia. Haemophilia 2012;18:e273–6.
    OpenUrlPubMed
  92. 92.↵
    1. Crowther MA,
    2. Douketis JD,
    3. Schnurr T,
    4. et al
    . Oral vitamin K lowers the international normalized ratio more rapidly than subcutaneous vitamin K in the treatment of warfarin-associated coagulopathy. A randomized, controlled trial. Ann Intern Med 2002;137:251–4.
    OpenUrlCrossRefPubMedWeb of Science
  93. 93.↵
    1. Lubetsky A,
    2. Yonath H,
    3. Olchovsky D,
    4. Loebstein R,
    5. Halkin H,
    6. Ezra D
    . Comparison of oral vs intravenous phytonadione (vitamin K1) in patients with excessive anticoagulation: a prospective randomized controlled study. Arch Intern Med 2003;163:2469–73.
    OpenUrlCrossRefPubMedWeb of Science
  94. 94.↵
    1. Raj G,
    2. Kumar R,
    3. McKinney WP
    . Time course of reversal of anticoagulant effect of warfarin by intravenous and subcutaneous phytonadione. Arch Intern Med 1999;159:2721–4.
    OpenUrlCrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

The Journal of the American Board of Family     Medicine: 27 (4)
The Journal of the American Board of Family Medicine
Vol. 27, Issue 4
July-August 2014
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • Index by author
  • Back Matter (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Board of Family Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Identification and Basic Management of Bleeding Disorders in Adults
(Your Name) has sent you a message from American Board of Family Medicine
(Your Name) thought you would like to see the American Board of Family Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
2 + 2 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Identification and Basic Management of Bleeding Disorders in Adults
Rebecca Kruse-Jarres, Tammuella C. Singleton, Cindy A. Leissinger
The Journal of the American Board of Family Medicine Jul 2014, 27 (4) 549-564; DOI: 10.3122/jabfm.2014.04.130227

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Identification and Basic Management of Bleeding Disorders in Adults
Rebecca Kruse-Jarres, Tammuella C. Singleton, Cindy A. Leissinger
The Journal of the American Board of Family Medicine Jul 2014, 27 (4) 549-564; DOI: 10.3122/jabfm.2014.04.130227
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Diagnostic Considerations in an Adult With a Potential Bleeding Disorder
    • Therapeutic Strategies in Patients With Bleeding Disorders
    • Conclusions
    • Acknowledgments
    • Notes
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Context and Trade-offs in Family Medicine
  • Google Scholar

More in this TOC Section

  • Interpretating Normal Values and Reference Ranges for Laboratory Tests
  • Non-Surgical Management of Urinary Incontinence
  • Screening and Diagnosis of Type 2 Diabetes in Sickle Cell Disease
Show more Clinical Reviews

Similar Articles

Keywords

  • Blood Coagulation Disorders
  • Blood Platelet Disorders
  • Coagulation Protein Disorders
  • Partial Thromboplastin Time
  • Prothrombin Time

Navigate

  • Home
  • Current Issue
  • Past Issues

Authors & Reviewers

  • Info For Authors
  • Info For Reviewers
  • Submit A Manuscript/Review

Other Services

  • Get Email Alerts
  • Classifieds
  • Reprints and Permissions

Other Resources

  • Forms
  • Contact Us
  • ABFM News

© 2025 American Board of Family Medicine

Powered by HighWire