Article Figures & Data
Figures
- Figure 1.
Histology of gastric biopsies showing eosinophilic infiltration. A: The biopsy consists of gastric antral type mucosa that is heavily infiltrated by eosinophils. B: Many high-power fields contain more than 50 eosinophils. In addition, eosinophils infiltrate the glandular epithelium, and many of the glands appear damaged and exhibit reactive atypia. C: In addition, there appears to be loss of a significant number of glands. This may explain the atrophic appearance noted during endoscopic examination. The histologic features are characteristic of eosinophilic gastroenteritis.
- Figure 2.
Algorithm for the workup and treatment of eosinophilic gastroenteritis. ANA, antinuclear antibody.
Tables
Type Symptoms Treatment Mucosal Anemia from iron deficiency or occult fecal blood loss, protein-losing enteropathy, and malabsorption, peripheral edema Most frequent type Elimination diet Cromoglycate Ketotifen Glucocorticosteroids Azathioprine Submucosal Bowel wall thickening results in obstructive signs (colicky pain, nausea, vomiting) At risk for bowel obstruction Montelukast Imatinib mesylate Omalizumab Serosal Associated with ascites, bloating, high peripheral eosinophilia, peritonitis Rarest form Histamine 2 receptor blockers Proton pump inhibitors Adapted from Refs. 6–9.
Systemic disorders Vasculitis: Churg-Strauss syndrome or polyarteritis nodosa Connective tissue disease: scleroderma, dermatomyositis, eosinophilia-myalgia syndrome Others: idiopathic hypereosinophilia, mastocytosis, histocytosis X, nonlipid histiocytosis, eosinophilic granuloma Tumors Carcinomas, lymphomas Intestinal Inflammatory bowel disorders Intestinal perforation Food allergies Cow milk enteropathy Parasites Parasites (Ancylostoma caninum, giardiasis, strongyloidosis, other zoonoses) Toxins Drugs (aspirin, sulfonamides, penicillin, cephalosporin, carbamazepine, azathioprine, l-tryptophan, and gold salts) Adapted from Ref. 2.
