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Research ArticleOriginal Research

Dietary Fiber for the Treatment of Type 2 Diabetes Mellitus: A Meta-Analysis

Robert E. Post, Arch G. Mainous, Dana E. King and Kit N. Simpson
The Journal of the American Board of Family Medicine January 2012, 25 (1) 16-23; DOI: https://doi.org/10.3122/jabfm.2012.01.110148
Robert E. Post
MD, MS
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Arch G. Mainous III
PhD
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Dana E. King
MD, MS
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Kit N. Simpson
DrPH
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    Figure 1.

    Flow diagram for selection of studies for meta-analysis.

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    Figure 2.

    Forest plot for fasting blood glucose. Mean, SD, and mean difference are shown in units of mmol/L.

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    Figure 3.

    Forest plot for glycosylated hemoglobin.

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    Table 1.

    Intervention Details of Included Studies

    StudySpecific Fiber TypeSoluble FiberIntervention
    Karlstrom 1984Cereal and unknownSoluble and insolubleA high-fiber diet (42.4 g) versus a control diet (18.9 g fiber). Diets were identical in the proportion of carbohydrate, fat, protein, and cholesterol.
    Hollenbeck 1986UnknownUnknownA high-fiber diet (27 g/1000 kcal) versus a control diet (11 g fiber/1000 kcal). Diets were identical in the proportion of carbohydrate, fat, protein, and cholesterol.
    Holman 1987Guar gumSolubleGuar minitablets (5 g), taken 3 times a day taken immediately before the first mouthful of each meal and washed down with water. Of note, all patients had achieved near-normal fasting plasma glucose levels before study began.
    Hagander 1988Cereal, beet, and leguminousSoluble and insolubleHigh-fiber versus low-fiber diets without changing energy intake or proportions of protein, fat, and carbohydrates.
    Uusitupa 1989Guar gumSolubleGuar gum granules (5 g), premixed with juice, milk, or water (1–2 dL), 3 times a day before main meals.
    Lalor 1990Guar gumSolubleGuar gum granules (5 g) at meal times 3 times daily.
    Karlander 1991 (diet only arm)Beet fiberSolubleBeet fiber (16 g) mixed into meals divided over 3 meals a day.
    Chuang 1992Guar gumSolubleGuar gum (5 g) taken before or with meals in a liquid form 3 times a day.
    Chandalia 2000Unfortified foods (e.g. cantaloupe, sweet potato, oatmeal)Soluble and insolubleA high-fiber diet (50 g) versus a control diet (24 g fiber). Diets were identical in the proportion of carbohydrate, fat, protein, and cholesterol.
    Jenkins 2002Cereal fiberSoluble and insolubleBread and breakfast cereals high in cereal fiber were provided to add 19 g/day of additional cereal fiber compared with an additional 4 g/day of additional cereal fiber in the control group.
    Feldheim 2003Wheat fiberSoluble and insolubleConsumption of bread and crescents enriched with a dietary fiber concentrate.
    Lu 2004Arabinoxylan-rich fiberSoluble and insolubleUsual diet supplemented with arabinoxylane fiber-enriched bread and muffins compared with non–fiber-enriched bread and muffins in the control group.
    Cho 2005Cassia tora fiberSolubleTwo 2-g packets per day ingested after meals, i.e., one packet each after morning and evening meal.
    Ziai 2005Plantago ovata Forsk (Psyllium)Soluble and insolubleFiber supplement (5.1 g) in 250 mL of water twice a day, 20–30 minutes before the morning and evening meals.
    Ikem 2007UnknownUnknownA high-fiber diet (40 g of fiber added) versus a control diet. Diets were similar in the proportion of carbohydrate, fat, and protein.
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    Table 2.

    Demographics of included studies

    Study (Sample Size)Study TypeFollow-Up Time (weeks)Increase in Fiber Versus Control Group (g)Female Sex (%)Age (Mean Years [SD])Body Mass Index (Mean [SD])Study Quality by GRADE Assessment
    Control GroupFiber GroupControl GroupFiber GroupControl GroupFiber Group
    Karlstrom 1984 (n = 28)RXO323.55050NRNRNRNRHigh
    Hollenbeck 1986 (n = 12)RXO431.4NRNR55.0 (4.0)55.0 (4.0)25.8 (1.4)25.8 (1.4)Moderate
    Holman 1987 (n = 58)RXO81517.217.254.2 (10.7)54.2 (10.7)26.5 (3.1)26.5 (3.1)High
    Hagander 1988 (n = 28)RXO82864.364.369.1 (5.6)69.1 (5.6)29.2 (4.4)29.2 (4.4)High
    Uusitupa 1989 (n = 39)RCT121573.460NRNRNRNRHigh
    Lalor 1990 (n = 38)RXO1215NRNRNRNRNRNRHigh
    Karlander 1991 (n = 10) (diet only arm)RXO616808057.2 (8.9)57.2 (8.9)32.5 (4.0)32.5 (4.0)Moderate
    Chuang 1992 (n = 32)RXO81556.356.352.1 (14.4)52.1 (14.4)25.7 (4.4)*25.7 (4.4)*High
    Chandalia 2000 (n = 26)RXO6267.77.761 (9)61 (9)32.3 (3.9)32.3 (3.9)High
    Jenkins 2002 (n = 46)RXO121530.430.463.0 (4.8)63.0 (4.8)26.7 (5.3)26.7 (5.3)High
    Feldheim 2003 (n = 19)RCT86NRNRNRNRNRNRModerate
    Lu 2004 (n = 30)RXO515606060.0 (7.7)60.0 (7.7)28.1 (3.5)28.1 (3.5)Moderate
    Cho 2005 (n = 30)RCT8453.353.357.2 (10.1)57.1 (11.2)23.4 (2.3)23.7 (1.5)High
    Ziai 2005 (n = 36)RCT810.2NRNR53.6 (8.1)51.9 (10.1)27.5 (3.5)26.6 (4.6)High
    Ikem 2007 (n = 52)RCT84041.154.358.2 (8.8)57.6 (6.3)24.5 (3.4)23.8 (3.3)High
    • ↵* Calculated from reported height and weight values.

    • NR, not reported; RCT, randomized controlled trial; RXO, randomized crossover trial.

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The Journal of the American Board of Family     Medicine: 25 (1)
The Journal of the American Board of Family Medicine
Vol. 25, Issue 1
January-February 2012
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Dietary Fiber for the Treatment of Type 2 Diabetes Mellitus: A Meta-Analysis
Robert E. Post, Arch G. Mainous, Dana E. King, Kit N. Simpson
The Journal of the American Board of Family Medicine Jan 2012, 25 (1) 16-23; DOI: 10.3122/jabfm.2012.01.110148

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Dietary Fiber for the Treatment of Type 2 Diabetes Mellitus: A Meta-Analysis
Robert E. Post, Arch G. Mainous, Dana E. King, Kit N. Simpson
The Journal of the American Board of Family Medicine Jan 2012, 25 (1) 16-23; DOI: 10.3122/jabfm.2012.01.110148
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