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Review ArticleClinical Review

Pertussis, Pertussis Vaccine, and Care of Exposed Persons

Richard Kent Zimmerman, Ellen R. Wald and Ellen R. Ahwesh
The Journal of the American Board of Family Practice November 1996, 9 (6) 422-434; DOI: https://doi.org/10.3122/jabfm.9.6.422
Richard Kent Zimmerman
From the Department of Family Medicine and Clinical Epidemiology (RKZ, ERA), and the Departments of Pediatrics and Otolaryngology (ERW), University of Pittsburgh School of Medicine, Pittsburgh. Address reprint requests to ATPM, Suite 204, 1511 South Ritchie Highway, Arnold, MD 21012
MD, MPH
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Ellen R. Wald
From the Department of Family Medicine and Clinical Epidemiology (RKZ, ERA), and the Departments of Pediatrics and Otolaryngology (ERW), University of Pittsburgh School of Medicine, Pittsburgh. Address reprint requests to ATPM, Suite 204, 1511 South Ritchie Highway, Arnold, MD 21012
MD
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Ellen R. Ahwesh
From the Department of Family Medicine and Clinical Epidemiology (RKZ, ERA), and the Departments of Pediatrics and Otolaryngology (ERW), University of Pittsburgh School of Medicine, Pittsburgh. Address reprint requests to ATPM, Suite 204, 1511 South Ritchie Highway, Arnold, MD 21012
MA
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Abstract

Background: Pertussis is a highly contagious bacterial infection caused by Bordetella pertussis. Before routine vaccination against pertussis was available, most persons were infected during childhood. After widespread vaccination, however, the incidence of pertussis in the United States dropped by more than 95 percent, though localized outbreaks continue to occur.

Methods: A multidisciplinary team developed a set of review articles as part of continuing medical education modules in the Teaching Immunization in Medical Education (TIME) Project. The team developed the materials using expert judgment and selected materials from the literature and the Centers for Disease Control and Prevention (CDC). The first step was the creation of specific learning objectives that used the spectrum of Bloom's taxonomy, when possible. After the materials were developed, they were pilot-tested and revised. Subsequently they underwent summative evaluation by field-testing the materials with 24 other primary care physicians. Then the materials were reviewed by the CDC and national vaccine experts and revised based on their comments.

Results and Conclusions: The efficacy of whole-cell pertussis vaccine is about 70 to 90 percent, though local adverse events are common. Since 1990 several purified, acellular pertussis vaccines have been developed that have one quarter to one half of the common adverse events associated with whole-cell vaccine and have similar efficacy rates. The incidence of pertussis can be further reduced by increasing age-appropriate vaccination rates.

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The Journal of the American Board of Family     Practice: 9 (6)
The Journal of the American Board of Family Practice
Vol. 9, Issue 6
1 Nov 1996
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Pertussis, Pertussis Vaccine, and Care of Exposed Persons
Richard Kent Zimmerman, Ellen R. Wald, Ellen R. Ahwesh
The Journal of the American Board of Family Practice Nov 1996, 9 (6) 422-434; DOI: 10.3122/jabfm.9.6.422

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Pertussis, Pertussis Vaccine, and Care of Exposed Persons
Richard Kent Zimmerman, Ellen R. Wald, Ellen R. Ahwesh
The Journal of the American Board of Family Practice Nov 1996, 9 (6) 422-434; DOI: 10.3122/jabfm.9.6.422
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