Potential Drawbacks of Noninvasive Diagnostic Methods for Nonalcoholic Fatty Liver Disease

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Figure 1.
Fibroscan procedure. (Left) Examining probe at the right hypochondrial region of the patient; (right) display monitor of transient elastography value and waveform. Courtesy of Gut Care, Singapore.
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Figure 2.
MRI-proton density fat fraction (MRI-PDFF). (A) Normal MRI-PDFF with PDFF < 6.5%; (B) MRI-PDFF with Grade 1 Fatty Liver [> 6.5% and < 17.4%]; (C) MRI-PDFF with Grade 2 Fatty Liver [> 17.4% and < 22.1%]; (D) MRI-PDFF with Grade 3 Fatty Liver [> 22.1%]. Courtesy of Dr. Mahesh K Goenka.

Table 1.

Noninvasive Methods of Liver Steatosis and Fibrosis

	Blood Biomarkers for Liver Steatosis and Fibrosis
Vibration Controlled Enhanced Tests for Steatosis and Fibrosis (VCTE)	Simple Fibrosis Score	Composite Fibrosis Markers	Markers of Liver Steatosis and Inflammation	Imaging Methods
Known as: Transient Elastography (TE)	BARD score	Enhanced Liver Fibrosis Test (ELF)	SteatoTest	US of the abdomen (US)
Liver Stiffness Measurement (LSM)	BAAT score	FibroTest (FT)	Fatty Liver Index (FLI)	CT scan of the abdomen (CT)
	AST to Platelet Ratio Index (APRI)			MRI of the Liver (MRI)
	AST/ALT ratio (AAR)
	Fibrosis 4 index (FIB-4)
	Fibrometer
	MASLD Score (NFS)