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Research ArticleOriginal Research

Infant and Maternal Vitamin D Supplementation: Clinician Perspectives and Practices

Andrea J. Aul, Philip R. Fischer, Matthew R. Benson, Sara S. Oberhelman-Eaton, Kristin C. Mara and Tom D. Thacher
The Journal of the American Board of Family Medicine February 2023, 36 (1) 95-104; DOI: https://doi.org/10.3122/jabfm.2022.220244R1
Andrea J. Aul
From Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Pediatrics, Sheikh Shakhbout Medical City, Abu Dhabi, UAE; Khalifa University, Abu Dhabi, UAE; Division of Endocrinology, Diabetes, and Metabolism, Nemours Children’s Health, Jacksonville, FL; Department of Family Medicine, Mayo Clinic, Rochester, MN; and Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
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Philip R. Fischer
From Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Pediatrics, Sheikh Shakhbout Medical City, Abu Dhabi, UAE; Khalifa University, Abu Dhabi, UAE; Division of Endocrinology, Diabetes, and Metabolism, Nemours Children’s Health, Jacksonville, FL; Department of Family Medicine, Mayo Clinic, Rochester, MN; and Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
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Matthew R. Benson
From Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Pediatrics, Sheikh Shakhbout Medical City, Abu Dhabi, UAE; Khalifa University, Abu Dhabi, UAE; Division of Endocrinology, Diabetes, and Metabolism, Nemours Children’s Health, Jacksonville, FL; Department of Family Medicine, Mayo Clinic, Rochester, MN; and Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
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Sara S. Oberhelman-Eaton
From Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Pediatrics, Sheikh Shakhbout Medical City, Abu Dhabi, UAE; Khalifa University, Abu Dhabi, UAE; Division of Endocrinology, Diabetes, and Metabolism, Nemours Children’s Health, Jacksonville, FL; Department of Family Medicine, Mayo Clinic, Rochester, MN; and Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
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Kristin C. Mara
From Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Pediatrics, Sheikh Shakhbout Medical City, Abu Dhabi, UAE; Khalifa University, Abu Dhabi, UAE; Division of Endocrinology, Diabetes, and Metabolism, Nemours Children’s Health, Jacksonville, FL; Department of Family Medicine, Mayo Clinic, Rochester, MN; and Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
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Tom D. Thacher
From Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; Department of Pediatrics, Sheikh Shakhbout Medical City, Abu Dhabi, UAE; Khalifa University, Abu Dhabi, UAE; Division of Endocrinology, Diabetes, and Metabolism, Nemours Children’s Health, Jacksonville, FL; Department of Family Medicine, Mayo Clinic, Rochester, MN; and Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
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    Figure 1.

    Proportion of Clinicians Who Would Recommend High-Dose Vitamin D Supplementation of the Mother, Direct Supplementation of the Infant, or Both Options If Each Provided Adequate Vitamin D Status in the Infant and Both Were Safe. Abbreviations: IC, infant-only clinicians; MIC, mother-and-infant clinicians.

Tables

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    Table 1.

    Demographic Features of Clinicians

    IC (n = 168)MIC (n = 192)Total (n = 360)P-Value
    Gender   0.99
        Female129 (76.8%)147 (76.6%)276 (76.7%) 
        Male37 (22.0%)43 (22.4%)80 (22.2%) 
        Prefer not to answer2 (1.2%)2 (1.0%)4 (1.1%) 
    Age (years)   0.16
        Missing011 
        18 to 2925 (14.9%)14 (7.3%)39 (10.9%) 
        30 to 3975 (44.6%)94 (49.2%)169 (47.1%) 
        40 to 4938 (22.6%)45 (23.6%)83 (23.1%) 
        50 to 5921 (12.5%)29 (15.2%)50 (13.9%) 
        60 to 699 (5.4%)7 (3.7%)16 (4.5%) 
        70+0 (0.0%)2 (1.0%)2 (0.6%) 
    Level of training   <0.001
        Midwife (RN only)0 (0.0%)6 (3.1%)6 (1.7%) 
        Nurse Practitioner14 (8.3%)35 (18.2%)49 (13.6%) 
        Other (specify)1 (0.6%)5 (2.6%)6 (1.7%) 
        Physician Assistant2 (1.2%)16 (8.3%)18 (5.0%) 
        Physician, fellow1 (0.6%)1 (0.5%)2 (0.6%) 
        Physician, practicing112 (66.7%)106 (55.2%)218 (60.6%) 
        Physician, resident38 (22.6%)23 (12.0%)61 (16.9%) 
    Clinician type<0.001
        Nurse Practitioner/Midwife14 (8.3%)41 (21.4%)55 (15.3%)
    Physician151 (89.9%)130 (67.7%)281 (78.1%)
        Other3 (1.8%)21 (10.9%)24 (6.7%)
    Year in residency   0.54
        N/A131169300 
        First year11 (29.7%)5 (21.7%)16 (26.7%) 
        Second year15 (40.5%)8 (34.8%)23 (38.3%) 
        Third year or greater11 (29.7%)10 (43.5%)21 (35.0%) 
    Years in practice   0.23
        Missing392463 
        Less than 5 years31 (24.0%)57 (33.9%)88 (29.6%)
        5 to 9 years35 (27.1%)43 (25.6%)78 (26.3%)
        10 to 19 years35 (27.1%)33 (19.6%)68 (22.9%) 
        20 years or more28 (21.7%)35 (20.8%)63 (21.2%) 
    Primary practice   
        Family Medicine0 (0.0%)160 (83.3%)160 (44.4%) 
        Neonatology7 (4.2%)0 (0.0%)7 (1.9%) 
        Newborn Nursery10 (6.0%)0 (0.0%)10 (2.8%) 
        Obstetrics/Gynecology0 (0.0%)26 (13.5%)26 (7.2%) 
        Primary Care Pediatrics144 (85.7%)0 (0.0%)144 (40.0%) 
        Other (specify)7 (4.2%)6 (3.1%)13 (3.6%)
    Additional training in lactation medicine   0.03
        Missing022 
        No132 (78.6%)166 (87.4%)298 (83.2%) 
        Yes36 (21.4%)24 (12.6%)60 (16.8%) 
    Country of practice   0.04
        United States168 (100.0%)187 (97.4%)355 (98.6%)
        Other0 (0.0%)5 (2.6%)5 (1.4%) 
    Have own children   0.01
        No48 (28.6%)32 (16.7%)80 (22.2%) 
        Yes120 (71.4%)160 (83.3%)280 (77.8%) 
    Clinician/partner provided breast milk to own infant   0.29
        Missing493382 
        Not applicable3 (2.5%)1 (0.6%)4 (1.4%)
        No4 (3.4%)9 (5.7%)13 (4.7%) 
        Yes112 (94.1%)149 (93.7%)261 (93.9%) 
    Clinician supplemented own infant or self/partner for the purpose of supporting own infant’s supplementation needs with vitamin D   0.56
        Missing493281 
        Not applicable2 (1.7%)2 (1.3%)4 (1.4%)
        Unsure3 (2.5%)6 (3.8%)9 (3.2%)
        No25 (21.0%)44 (27.5%)69 (24.7%) 
        Yes89 (74.8%)108 (67.5%)197 (70.6%) 
    Age of your youngest child   0.59
        Missing493281 
        Less than 13 years old91 (76.5%)113 (70.6%)204 (73.1%)
        13 to 18 years old9 (7.6%)19 (11.9%)28 (10.0%) 
        19 to 30 years old16 (13.4%)25 (15.6%)41 (14.7%) 
        31 to 40 years old3 (2.5%)3 (1.9%)6 (2.2%) 
    • Abbreviations: IC, infant-only clinicians; MIC, mother-and-infant clinicians.

    • View popup
    Table 2.

    Current Vitamin D Supplementation Prescribing Practices of Infant-Only Clinicians and Clinicians Who Care for Mothers and Infants

    IC (n = 168)MIC (n = 192)Total (n = 360)P-Value
    Times have you seen a child with nutritional rickets   <0.001
        087 (51.8%)184 (95.8%)271 (75.3%) 
        1 to 254 (32.1%)8 (4.2%)62 (17.2%)
        3 to 518 (10.7%)0 (0.0%)18 (5.0%)
        6 to 106 (3.6%)0 (0.0%)6 (1.7%) 
        11 or more3 (1.8%)0 (0.0%)3 (0.8%) 
    Times have you seen a child with vitamin D toxicity   0.002
        0148 (88.1%)189 (98.4%)337 (93.6%) 
        1 to 216 (9.5%)2 (1.0%)18 (5.0%)
        3 to 51 (0.6%)1 (0.5%)2 (0.6%)
        6 to 101 (0.6%)0 (0.0%)1 (0.3%) 
        11 or more2 (1.2%)0 (0.0%)2 (0.6%) 
    How often you recommend vitamin D supplementation to exclusively breastfed infants? Median (IQR)100 (100, 100) 100 (90, 100) 100 (95, 100) <0.001
    How often you recommend vitamin D supplementation to partially breastfed infants or infants receiving less than 1000 mL of formula daily? Median (IQR) 90 (60.5, 100)80 (30, 100) 84 (50, 100) 0.005
    Why do you recommend vitamin D supplementation?   
        Missing11516
        To follow guideline recommendations161 (96.4%)161 (91.0%)322 (93.6%)0.04
        Because vitamin D deficiency occurs in the region where I practice73 (43.7%)78 (44.1%)151 (43.9%) 0.95
        To prevent rickets102 (61.1%)57 (32.2%)159 (46.2%) <0.001
        Other8 (4.8%)4 (2.3%)12 (3.5%)0.20 
    Why do you not recommend vitamin D supplementation?   
        Missing168179347
        I am not aware of any guideline recommendations to do so4 (30.8%)4 (30.8%)
        I have other priorities during the infant visit1 (7.7%)1 (7.7%)
        Breastfed infants can get vitamin D from mothers who take adequate vitamin D2 (15.4%)2 (15.4%)
        Other9 (69.2%)9 (69.2%)
    How do you recommend vitamin D supplementation be given?   
        Missing01616
        To infants via vitamin D drops161 (95.8%)158 (89.8%)319 (92.7%) 0.03
        To breastfeeding mothers via a prenatal vitamin only3 (1.8%)19 (10.8%)22 (6.4%) <0.001
        To breastfeeding mothers in doses higher than in a prenatal vitamin32 (19.0%)47 (26.7%)79 (23.0%)0.09 
        I discuss infant and maternal supplementation options and let the parents/caregivers choose37 (22.0%)61 (34.7%)98 (28.5%)0.009 
        I do not recommend vitamin D supplementation, but I encourage regular sunlight exposure0 (0.0%)2 (1.1%)2 (0.6%)0.17 
        Other2 (1.2%)5 (2.8%)7 (2.0%)0.28 
    • Abbreviations: IC, infant-only clinicians; MIC, mother-and-infant clinicians; IQR, interquartile ratio.

    • View popup
    Table 3.

    Vitamin D Supplementation Prescribing Preferences of Infant-Only Clinicians and Clinicians Who Care for Mothers and Infants

    IC (n = 168)MIC (n = 192)Total (n = 360)P-Value
    If supplementing the mother or the infant each provided adequate vitamin D status in the infant and both were safe, which option do you think most parents/caregivers would prefer?   0.002
        Supplementation of the infant25 (14.9%)14 (7.3%)39 (10.8%) 
        Supplementation of the mother76 (45.2%)121 (63.0%)197 (54.7%) 
        Both options would be equally preferred67 (39.9%)57 (29.7%)124 (34.4%)
    Which option would lead to greater adherence?   0.005
        Missing011 
        Supplementation of the infant35 (20.8%)25 (13.1%)60 (16.7%) 
        Supplementation of the mother83 (49.4%)127 (66.5%)210 (58.5%) 
        Both options would lead to equal adherence50 (29.8%)39 (20.4%)89 (24.8%)
    Which option would most likely promote breastfeeding?   0.002
        Missing101 
        Supplementation of the infant6 (3.6%)8 (4.2%)14 (3.9%) 
        Supplementation of the mother61 (36.5%)105 (54.7%)166 (46.2%) 
        Both options would equally promote breastfeeding100 (59.9%)79 (41.1%)179 (49.9%)
    Which option would you recommend to families?   0.007
        Supplementation of the infant36 (21.4%)23 (12.0%)59 (16.4%) 
        Supplementation of the mother15 (8.9%)34 (17.7%)49 (13.6%) 
        I would offer both and let the parent/caregiver choose117 (69.6%)135 (70.3%)252 (70.0%)
    • Abbreviations: IC, infant-only clinicians; MIC, mother-and-infant clinicians.

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Infant and Maternal Vitamin D Supplementation: Clinician Perspectives and Practices
Andrea J. Aul, Philip R. Fischer, Matthew R. Benson, Sara S. Oberhelman-Eaton, Kristin C. Mara, Tom D. Thacher
The Journal of the American Board of Family Medicine Feb 2023, 36 (1) 95-104; DOI: 10.3122/jabfm.2022.220244R1

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Infant and Maternal Vitamin D Supplementation: Clinician Perspectives and Practices
Andrea J. Aul, Philip R. Fischer, Matthew R. Benson, Sara S. Oberhelman-Eaton, Kristin C. Mara, Tom D. Thacher
The Journal of the American Board of Family Medicine Feb 2023, 36 (1) 95-104; DOI: 10.3122/jabfm.2022.220244R1
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