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Research ArticleOriginal Research

Nonadherence to Clinical Practice Guidelines for Opioid Prescribing in Patients with Chronic Low Back Pain: A Pain Research Registry–Based Study

John C. Licciardone and Subhash Aryal
The Journal of the American Board of Family Medicine July 2022, 35 (4) 724-732; DOI: https://doi.org/10.3122/jabfm.2022.04.210432
John C. Licciardone
University of North Texas Health Science Center, Department of Family Medicine (JCL); and University of Pennsylvania, School of Nursing (SA).
DO, MS, MBA
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Subhash Aryal
University of North Texas Health Science Center, Department of Family Medicine (JCL); and University of Pennsylvania, School of Nursing (SA).
PhD
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  • Article
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Article Figures & Data

Tables

    • View popup
    Table 1.

    Participant Characteristics According to CPG Adherence Status*

    CharacteristicAdherent to CPGsNon-Adherent to CPGsP
    (n = 1051)(n = 68)
    No.%No.%
    Age, yr (mean ± SD)52.9 ± 13.257.5 ± 11.40.002
    Sex0.01
        Female79875.94261.8
        Male25324.12638.2
    Race0.15
        Black18117.21826.5
        Other272.622.9
        White84380.24870.6
    Ethnicity0.25
        Hispanic888.434.4
        Non-Hispanic96391.66595.6
    Educational level<0.001
        High school or lower17116.32841.2
        Some post-high school44842.62739.7
        College degree or higher43241.11319.1
    Cigarette smoking status0.03
        Never or former smoker88283.95073.5
        Current smoker16916.11826.5
    Body mass index (mean ± SD)32.4 ± 8.235.3 ± 11.00.04
    Duration of low back pain0.46
        <5 years32330.71826.5
        ≥5 years72869.35073.5
    Bothersomeness of widespread pain<0.001
        Not at all37535.71319.1
        A little bit40438.42232.4
        A lot27225.93348.5
    Pain catastrophizing (mean ± SD)19.1 ± 13.125.4 ± 14.4<0.001
    Pain self-efficacy (mean ± SD)33.6 ± 14.926.4 ± 14.3<0.001
    No. of comorbidities (mean ± SD)1.8 ± 0.81.8 ± 0.70.62
    Herniated disc0.02
        No65962.73348.5
        Yes39237.33551.5
    Sciatica0.95
        No53050.43450.0
        Yes52149.63450.0
    Osteoarthritis0.34
        No57254.43348.5
        Yes47945.63551.5
    Osteoporosis0.02
        No90786.35276.5
        Yes14413.71623.5
    Heart disease0.05
        No94489.85682.4
        Yes10710.21217.6
    Hypertension0.003
        No61258.22739.7
        Yes43941.84160.3
    Diabetes Mellitus0.21
        No85381.25175.0
        Yes19818.81725.0
    Asthma0.11
        No77373.54464.7
        Yes27826.52435.3
    Depression0.31
        No45343.12536.8
        Yes59856.94363.2
    • ↵* Table entries are No. and % unless otherwise indicated. The Pain Catastrophizing Scale and the Pain Self-Efficacy Questionnaire were each used to measure the respective characteristics. CPG denotes clinical practice guideline.

    • Abbreviation: SD, standard deviation.

    • View popup
    Table 2.

    Factors Associated with CPG Nonadherence (n = 1119)*

    CharacteristicOR95% CIP
    Age (yr)
        21 to 491……
        50 to 591.380.68 to 2.830.38
        ≥602.281.15 to 4.520.02
    Sex
        Female1……
        Male1.811.05 to 3.120.03
    Race
        White1……
        Black1.240.66 to 2.340.50
        Other1.650.35 to 7.700.53
    Ethnicity
        Non-Hispanic1……
        Hispanic0.530.15 to 1.820.31
    Educational level
        High school or lower1……
        Some post-high school education0.410.22 to 0.740.003
        College degree or higher0.260.12 to 0.56<0.001
    Cigarette smoking status
        Never or former smoker1……
        Current smoker1.120.59 to 2.140.72
    Body mass index
        <301……
        ≥301.400.80 to 2.450.24
    Duration of low back pain (yr)
        <51……
        ≥50.980.54 to 1.790.95
    Bothersomeness of widespread pain
        Not at all1……
        A little bit1.240.59 to 2.570.57
        A lot2.191.06 to 4.520.03
    Pain catastrophizing
        Low (<12)1……
        Medium (12 to 24)0.610.27 to 1.350.22
        High (≥25)1.040.47 to 2.280.93
    Pain self-efficacy
        Low (<27)1……
        Medium (27 to 41)0.770.41 to 1.420.40
        High (≥42)0.530.22 to 1.270.15
    No. of comorbidities
        <21……
        2 to 31.010.43 to 2.340.99
        ≥41.240.52 to 2.940.62
    • ↵* Odds ratios were adjusted for each other variable in the table. The Pain Catastrophizing Scale and the Pain Self-Efficacy Questionnaire were each used to classify participants according to tercile cutpoints on each instrument. CPG denotes clinical practice guideline.

    • Abbreviations: OR, odds ratio; CI, confidence interval.

    • View popup
    Table 3.

    Physician Interactions According to CPG Adherence Status*

    Physician InteractionAdherent to CPGsNon-Adherent to CPGsP
    (n = 891)(n = 56)
    Mean95% CIMean95% CI
    Physician communication behavior
        Patient participation and patient orientation68.766.9 to 70.475.369.3 to 81.30.04
        Effective and open communication69.768.0 to 71.475.769.7 to 81.80.09
        Emotionally supportive communication74.072.4 to 75.677.172.4 to 81.90.21
        Communication about personal circumstances58.156.2 to 59.959.551.4 to 67.60.71
    Physician empathy38.738.0 to 39.539.036.1 to 41.90.86
    Satisfaction with physician characteristics
        Technical quality3.83.7 to 3.83.83.6 to 4.00.66
        Interpersonal manner4.14.1 to 4.24.13.9 to 4.30.80
        Communications4.03.9 to 4.13.93.7 to 4.10.65
        Time spent with patient3.63.6 to 3.73.53.2 to 3.80.28
    • ↵* Interactions were self-reported by participants using the Communication Behavior Questionnaire, Consultation and Relational Empathy Measure, and Patient Satisfaction Questionnaire with 18 items, respectively. Analysis includes only those participants whose low back pain onset occurred during the time period in which they were treated by their current physician. Higher scores represent better physician interaction. CPG denotes clinical practice guideline.

    • Abbreviations: CI, confidence interval.

    • View popup
    Table 4.

    Primary Outcomes According to CPG Adherence Status*

    OutcomeAdherent to CPGsNon-Adherent to CPGsPCohen's d95% CI
    (n = 1051)(n = 68)
    Mean95% CIMean95% CI
    Pain intensity6.05.9.0 to 6.16.86.3 to 7.20.0010.410.16.0 to 0.65
    Back-related disability14.314.0 to 14.617.616.4 to 18.9<0.0010.590.34.0 to 0.84
    Pain impact on health-related quality of life30.830.3 to 31.436.334.4 to 38.1<0.0010.620.38.0 to 0.87
    • ↵* Outcomes were measured using a numerical rating scale for low back pain intensity, the Roland-Morris Disability Questionnaire, and the National Institutes of Health pain impact measure, respectively. Higher scores represent worse outcomes. CPG denotes clinical practice guideline.

    • Abbreviations: CI, confidence interval.

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The Journal of the American Board of Family     Medicine: 35 (4)
The Journal of the American Board of Family Medicine
Vol. 35, Issue 4
July/August 2022
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Nonadherence to Clinical Practice Guidelines for Opioid Prescribing in Patients with Chronic Low Back Pain: A Pain Research Registry–Based Study
John C. Licciardone, Subhash Aryal
The Journal of the American Board of Family Medicine Jul 2022, 35 (4) 724-732; DOI: 10.3122/jabfm.2022.04.210432

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Nonadherence to Clinical Practice Guidelines for Opioid Prescribing in Patients with Chronic Low Back Pain: A Pain Research Registry–Based Study
John C. Licciardone, Subhash Aryal
The Journal of the American Board of Family Medicine Jul 2022, 35 (4) 724-732; DOI: 10.3122/jabfm.2022.04.210432
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Keywords

  • Health Care Outcome Assessment
  • Health Literacy
  • Low Back Pain
  • Multivariate Analysis
  • Opioids
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  • Quality of Life
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