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Research ArticleOriginal Research

High Prevalence of Both Previous Infection with SARS-CoV-2 and Persistent Symptoms

Mark H. Ebell, David Forgacs, Ye Shen, Ted M. Ross, Cassie Hulme, Michelle Bentivegna, Hannah B. Hanley, Alexandria M. Jefferson and Lauren Hainess
The Journal of the American Board of Family Medicine May 2022, 35 (3) 570-578; DOI: https://doi.org/10.3122/jabfm.2022.03.210348
Mark H. Ebell
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
MD, MS
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David Forgacs
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
PhD
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Ye Shen
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
PhD
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Ted M. Ross
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
PhD
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Cassie Hulme
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
MPH
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Michelle Bentivegna
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
MPH
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Hannah B. Hanley
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
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Alexandria M. Jefferson
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
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Lauren Hainess
From University of Georgia, College of Public Health, Department of Epidemiology and Biostatistics (MHE, YS, CH, MB, LH); University of Georgia, College of Veterinary Medicine, Center for Vaccines and Immunology (DF, TMR, HBH, AMJ); University of Georgia, College of Veterinary Medicine, Department of Infectious Diseases (TMR).
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References

  1. 1.↵
    1. Buitrago-Garcia D,
    2. Egli-Gany D,
    3. Counotte MJ,
    4. et al
    . Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis. PLoS Med 2020;17:e1003346.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Oran DP,
    2. Topol EJ
    . Prevalence of asymptomatic SARS-CoV-2 infection: a narrative review. Ann Intern Med 2020; Jun 3:M20-3012.
  3. 3.↵
    1. Lee S,
    2. Kim T,
    3. Lee E,
    4. et al
    . Clinical course and molecular viral shedding among aymptomatic and symptomatic patients with SARS-CoV-2 infection in a community treatment center in the Republic of Korea. JAMA Intern Med 2020;180:1447.
    OpenUrl
  4. 4.↵
    1. McEvoy D,
    2. McAloon C,
    3. Collins A,
    4. et al
    . Relative infectiousness of asymptomatic SARS-CoV-2 infected persons compared with symptomatic individuals: a rapid scoping review. BMJ Open 2021;11:e042354.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Poletti P,
    2. Tirani M,
    3. Cereda D
    , ATS Lombardy COVID-19 Task Forceet al. Association of age with likelihood of developing symptoms and critical disease among close contacts exposed to patients with confirmed SARS-CoV-2 infection in Italy. JAMA Netw Open 2021;4:e211085.
    OpenUrl
  6. 6.↵
    1. Ebell MH,
    2. Chupp C,
    3. Bentivegna M
    . A high proportion of SARS-CoV-2-infected university students are asymptomatic. J Fam Pract 2020;69:428–9.
    OpenUrlPubMed
  7. 7.↵
    1. Chohan BH,
    2. Lavreys L,
    3. Mandaliya KN,
    4. et al
    . Validation of a modified commercial enzyme-linked immunoassay for detection of human immunodeficiency virus type 1 immunoglobulin G antibodies in saliva. Clin Diagn Lab Immunol 2001;8:346–8.
    OpenUrlPubMed
  8. 8.↵
    1. MacMullan MA,
    2. Ibrayeva A,
    3. Trettner K,
    4. et al
    . ELISA detection of SARS-CoV-2 antibodies in saliva. Sci Rep 2020;10:20818.
    OpenUrlCrossRef
  9. 9.↵
    1. Hettegger P,
    2. Huber J,
    3. Paßecker K,
    4. et al
    . High similarity of IgG antibody profiles in blood and saliva opens opportunities for saliva based serology. PloS One 2019;14:e0218456.
    OpenUrl
  10. 10.↵
    1. Varadhachary A,
    2. Chatterjee D,
    3. Garza J,
    4. et al
    . Salivary anti-SARS-CoV-2 IgA as an accessible biomarker of mucosal immunity against COVID-19. MedRxiv 2020. Aug 11;2020.08.07.20170258. Preprint.
  11. 11.↵
    1. Mak T,
    2. Saunders M
    . Mucosal and cutaneous immunity. In: The immune response—basic and clinical principles. New York: Academic Press; 2006. p. 583–609.
  12. 12.
    1. Jureka AS,
    2. Silvas JA,
    3. Basler CF
    . Propagation, inactivation, and safety testing of SARS-CoV-2. Viruses 2020;12:622.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Youden WJ
    . Index for rating diagnostic tests. Cancer 1950;3:32–5.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Diggle PJ
    . Estimating Prevalence Using an Imperfect Test. Epidemiol Res Int 2011;2011:e608719.
    OpenUrl
  15. 15.↵
    Centers for Disease Control and Prevention [Internet]. Interim guidelines for COVID-19 antibody testing. Centers for Disease Control and Prevention; 2020 [cited 2021 June 17]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html.
  16. 16.↵
    The New York Times [Internet]. Tracking coronavirus cases at U.S. colleges and universities. The New York Times; 2021 [cited 2021 June 17]. https://www.nytimes.com/interactive/2021/us/college-covid-tracker.html.
  17. 17.↵
    1. Tilley K,
    2. Ayvazyan V,
    3. Martinez L,
    4. et al
    . A cross-sectional study examining the seroprevalence of severe acute respiratory syndrome coronavirus 2 antibodies in a university student population. J Adolesc Health 2020;67:763–8.
    OpenUrlPubMed
  18. 18.↵
    1. Kianersi S,
    2. Ludema C,
    3. Macy JT,
    4. et al
    . A cross-sectional analysis of demographic and behavioral risk factors of severe acute respiratory syndrome coronavirus 2 seropositivity among a sample of U.S. college students. J Adolesc Health Off Health 2021;69:219–26.
    OpenUrl
  19. 19.↵
    1. Vusirikala A,
    2. Whitaker H,
    3. Jones S,
    4. et al
    . Seroprevalence of SARS-CoV-2 antibodies in university students: Cross-sectional study, December 2020, England. J Infect 2021;83:104–11.
    OpenUrl
  20. 20.↵
    1. Gostin LO,
    2. Shaw J,
    3. Salmon DA
    . Mandatory SARS-CoV-2 vaccinations in K-12 schools, colleges/universities, and businesses. JAMA 2021;326:25.
    OpenUrl
  21. 21.↵
    1. Gibas C,
    2. Lambirth K,
    3. Mittal N,
    4. et al
    . Implementing building-level SARS-CoV-2 wastewater surveillance on a university campus. Sci Total Environ 2021;782:146749.
    OpenUrlCrossRef
  22. 22.↵
    1. Rennert L,
    2. McMahan C,
    3. Kalbaugh CA,
    4. et al
    . Surveillance-based informative testing for detection and containment of SARS-CoV-2 outbreaks on a public university campus: an observational and modelling study. Lancet Child Adolesc Health 2021;5:428–36.
    OpenUrl
  23. 23.↵
    ACHA [Internet]. ACHA recommends COVID-19 vaccination requirements for fall 2021. ACHA; [cited 2021 June 17]. https://www.acha.org/ACHA/About/ACHA_News/ACHA_Recommends_COVID-19_Vaccination_Requirements_for_Fall_2021.aspx.
  24. 24.↵
    1. Lerner AM,
    2. Robinson DA,
    3. Yang L,
    4. et al
    . Toward understanding COVID-19 recovery: National Institutes of Health workshop on postacute COVID-19. Ann Intern Med 2021;174:999–1003.
    OpenUrl
  25. 25.↵
    1. Havervall S,
    2. Rosell A,
    3. Phillipson M,
    4. et al
    . Symptoms and functional impairment assessed 8 months after mild COVID-19 among health care workers. JAMA 2021;325:2015–6.
    OpenUrlCrossRefPubMed
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The Journal of the American Board of Family Medicine: 35 (3)
The Journal of the American Board of Family Medicine
Vol. 35, Issue 3
May/June 2022
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High Prevalence of Both Previous Infection with SARS-CoV-2 and Persistent Symptoms
Mark H. Ebell, David Forgacs, Ye Shen, Ted M. Ross, Cassie Hulme, Michelle Bentivegna, Hannah B. Hanley, Alexandria M. Jefferson, Lauren Hainess
The Journal of the American Board of Family Medicine May 2022, 35 (3) 570-578; DOI: 10.3122/jabfm.2022.03.210348

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High Prevalence of Both Previous Infection with SARS-CoV-2 and Persistent Symptoms
Mark H. Ebell, David Forgacs, Ye Shen, Ted M. Ross, Cassie Hulme, Michelle Bentivegna, Hannah B. Hanley, Alexandria M. Jefferson, Lauren Hainess
The Journal of the American Board of Family Medicine May 2022, 35 (3) 570-578; DOI: 10.3122/jabfm.2022.03.210348
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Keywords

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