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Research ArticleOriginal Research

Retrospective Comparison of Cardiac Testing and Results on Inpatients with Low Pretest Probability Compared with Moderate/High Pretest Probability for Coronary Artery Disease

Aaron Lear, Merritt Huber, Amy Canada, Jessica Robertson, Evan Bosman and Stephen Zyzanski
The Journal of the American Board of Family Medicine March 2018, 31 (2) 219-225; DOI: https://doi.org/10.3122/jabfm.2018.02.170295
Aaron Lear
From the Cleveland Clinic Akron General Family Medicine, Akron, OH (AL); Medical University of South Carolina, Charleston, SC (MH); CHI Franciscan Family Medicine, Tacoma, WA (AC); Northeast Ohio Medical University, Rootstown (JR); Cleveland Clinic Akron General, Akron (EB); Case Western Reserve Department of Family Medicine, Cleveland (SZ).
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Merritt Huber
From the Cleveland Clinic Akron General Family Medicine, Akron, OH (AL); Medical University of South Carolina, Charleston, SC (MH); CHI Franciscan Family Medicine, Tacoma, WA (AC); Northeast Ohio Medical University, Rootstown (JR); Cleveland Clinic Akron General, Akron (EB); Case Western Reserve Department of Family Medicine, Cleveland (SZ).
MD
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Amy Canada
From the Cleveland Clinic Akron General Family Medicine, Akron, OH (AL); Medical University of South Carolina, Charleston, SC (MH); CHI Franciscan Family Medicine, Tacoma, WA (AC); Northeast Ohio Medical University, Rootstown (JR); Cleveland Clinic Akron General, Akron (EB); Case Western Reserve Department of Family Medicine, Cleveland (SZ).
MD
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Jessica Robertson
From the Cleveland Clinic Akron General Family Medicine, Akron, OH (AL); Medical University of South Carolina, Charleston, SC (MH); CHI Franciscan Family Medicine, Tacoma, WA (AC); Northeast Ohio Medical University, Rootstown (JR); Cleveland Clinic Akron General, Akron (EB); Case Western Reserve Department of Family Medicine, Cleveland (SZ).
BS
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Evan Bosman
From the Cleveland Clinic Akron General Family Medicine, Akron, OH (AL); Medical University of South Carolina, Charleston, SC (MH); CHI Franciscan Family Medicine, Tacoma, WA (AC); Northeast Ohio Medical University, Rootstown (JR); Cleveland Clinic Akron General, Akron (EB); Case Western Reserve Department of Family Medicine, Cleveland (SZ).
BA
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Stephen Zyzanski
From the Cleveland Clinic Akron General Family Medicine, Akron, OH (AL); Medical University of South Carolina, Charleston, SC (MH); CHI Franciscan Family Medicine, Tacoma, WA (AC); Northeast Ohio Medical University, Rootstown (JR); Cleveland Clinic Akron General, Akron (EB); Case Western Reserve Department of Family Medicine, Cleveland (SZ).
PhD
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    Figure 1.

    Flow diagram of included patients/results.

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    Table 1.

    Demographics and Medical Conditions of Included Subjects

    CategoryLow Risk n, (% of Low Risk)Moderate/High Risk n, (% of Mod/High Risk)P Value*Total (%)
    30 to 44 years98 (32)24 (10)—122 (22)
    45 to 65 years190 (62)190 (80).001†380 (70)
    > 65 years17 (6)24 (10)—41 (8)
    Male49 (16)177 (74).001226 (42)
    Diabetes37 (12)94 (40).001131 (24)
    HTN168 (55)154 (65).024322 (59)
    Hypercholesterolemia78 (26)103 (43).001181 (33)
    Obesity (BMI > 30)157 (52)116 (49).527273 (50)
    Smoker99 (33)141 (59).001240 (44)
    Total305238543 (100)
    • ↵* All P values are based on χ2 statistics.

    • ↵† P value for age applies to a difference between all age groups.

    • BMI, body mass index; HTN, hypertension.

    • View popup
    Table 2.

    Low Pretest probability vs. Moderate/High Pretest Probability Subjects

    Low Pretest ProbabilityModerate/High Pretest ProbabilityTotalRR* Low/MH (95% CI)P Value
    Stress tested (%)155/305 (51%)120/238 (50%)275/543 (51%)1.01 (0.852, 1.192).93†
    Positive or equivocal stress tests/stress tested (%)27/155 (17%)32/120 (27%)59/275 (21%)0.653 (0.415, 1.028).07†
    Positive coronary angiogram or CT/ positive or inconclusive stress test (%)0/16 (0%)14/29 (48%)14/45 (31%)0.061 (0.004, 0.957).001+
    • Testing results by Duke clinical score pretest probability category.

    • ↵* Relative risk of low pretest probability category compared to moderate/high pretest probability group.

    • ↵† P-value based on χ2.

    • + P-value based on Fisher's exact test.

    • CI, confidence interval; CT, computed tomography.

    • View popup
    Table 3.

    Stress Test Type

    Probability CategoryNo Stress Test (%)ECG Maximal (%)*Stress with Imaging (%)†Total (%)
    Low pretest probability151 (50)10 (3)144 (47)305 (100)
    Mod/high pretest probability118 (50)5 (2)115 (48)238 (100)
    Total269 (50)15 (3)259 (47)543 (100)
    • Provocative stress tests type by pretest probability.

    • ↵* ECG maximal: Treadmill stress test with ECG monitor-no imaging associated.

    • ↵† Stress with imaging: Includes both exercise and chemical stress test with echocardiography or nuclear imaging.

    • ECG, electrocardiogram.

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The Journal of the American Board of Family     Medicine: 31 (2)
The Journal of the American Board of Family Medicine
Vol. 31, Issue 2
March-April 2018
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Retrospective Comparison of Cardiac Testing and Results on Inpatients with Low Pretest Probability Compared with Moderate/High Pretest Probability for Coronary Artery Disease
Aaron Lear, Merritt Huber, Amy Canada, Jessica Robertson, Evan Bosman, Stephen Zyzanski
The Journal of the American Board of Family Medicine Mar 2018, 31 (2) 219-225; DOI: 10.3122/jabfm.2018.02.170295

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Retrospective Comparison of Cardiac Testing and Results on Inpatients with Low Pretest Probability Compared with Moderate/High Pretest Probability for Coronary Artery Disease
Aaron Lear, Merritt Huber, Amy Canada, Jessica Robertson, Evan Bosman, Stephen Zyzanski
The Journal of the American Board of Family Medicine Mar 2018, 31 (2) 219-225; DOI: 10.3122/jabfm.2018.02.170295
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