Article Figures & Data
Tables
- Table 1.
Distribution of Sociodemographics, Covariates, and 5-Year (2010–2015) Cumulative Incidence of Hypertension Among Adult Primary Care Patients, Overall and by ADM Exposure (n = 6244)
Variable Total (n = 6244) No ADM (n = 4182) ADM-BP− (n = 1008) ADM-BP+ (n = 1054) P Value Hypertension, cumulative incidence 774 (12.4) 507 (12.1) 125 (12.4) 142 (13.5) .494 Age (years), mean (SD) 46.4 (15.6) 46.0 (16.0) 47.2 (15.7) 47.2 (13.8) .012 White race 4297 (68.8) 2713 (64.9) 772 (76.6) 812 (77.0) <.0001 Female sex 3949 (63.2) 2449 (58.6) 706 (70.0) 794 (75.3) <.0001 Married 2968 (47.5) 2058 (49.2) 426 (42.3) 484 (45.9) <.001 High neighborhood SES 3649 (58.4) 2378 (56.9) 618 (61.3) 653 (62.0) .001 High clinic utilization 1380 (22.1) 628 (15.0) 297 (29.5) 455 (43.2) <.0001 Current smoker 1164 (18.6) 620 (14.8) 214 (21.2) 330 (31.3) <.0001 Substance use disorder 190 (3.0) 65 (1.6) 51 (5.1) 74 (7.0) <.0001 Depression 771 (12.4) 24 (0.6) 337 (33.4) 410 (38.9) <.0001 Any anxiety disorder 665 (10.7) 92 (2.2) 289 (28.7) 284 (26.9) <.0001 Obese 2365 (37.9) 1480 (35.4) 413 (41.0) 472 (44.8) <.0001 Hyperlipidemia 1429 (22.9) 898 (21.5) 261 (25.9) 270 (25.6) .001 Type 2 diabetes 391 (6.3) 228 (5.4) 79 (7.8) 84 (8.0) .001 Vascular disease 605 (9.7) 356 (8.5) 110 (10.9) 139 (13.2) <.0001 Data are n (%) unless otherwise indicated.
ADM, antidepressant medication; BP−, no effect on blood pressure; BP+, increases blood pressure; SD, standard deviation; SES, socioeconomic status.
- Table 2.
Survival Models, Hazard Ratios, and 95% Confidence Intervals of the Relationship of Antidepressant Medication Treatment Group and Time to Incident Hypertension among Adult Primary Care Patients (n = 6244), 2010–2015*
Crude HR (95% CI) Overall adjusted HR (95% CI) ADM None 1.00 1.00 BP− 1.10 (0.90–1.34) 1.08 (0.87–1.33) BP+ 1.30 (1.08–1.57) 1.20 (0.97–1.49) Age 1.04 (1.03–1.05) White race 0.60 (0.52–0.71) Female sex 0.93 (0.80–1.08) Married 1.08 (0.93–1.26) High neighborhood SES 0.93 (0.79–1.09) High clinic utilization 1.37 (1.17–1.61) Current smoker 1.43 (1.21–1.70) Substance use disorder 1.19 (0.80–1.76) Depression 0.88 (0.68–1.13) Any anxiety disorder 0.90 (0.68–1.18) Obese 1.78 (1.54–2.07) Hyperlipidemia 1.07 (0.91–1.26) Type 2 diabetes 1.62 (1.31–1.99) Vascular disease 0.99 (0.81–1.22) ADM, antidepressant medication; BP−, no effect on blood pressure; BP+, increases blood pressure; CI, confidence interval; HR, hazard ratio; SES, socioeconomic status.
↵* ADM treatment and comorbidities were treated as time-dependent variables.
