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Research ArticleOriginal Research

Presenting Signs of Multiple Myeloma and the Effect of Diagnostic Delay on the Prognosis

Neta Goldschmidt, Leora Zamir, Alina Poperno, Nathan R. Kahan and Ora Paltiel
The Journal of the American Board of Family Medicine November 2016, 29 (6) 702-709; DOI: https://doi.org/10.3122/jabfm.2016.06.150393
Neta Goldschmidt
From the Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (NG, LZ, OP); the Enforcement and Inspection Division, Israeli Ministry of Health, Jerusalem, Israel (AP); the Medical Division, Leumit Health Services, Tel-Aviv, Israel (NRK); the School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel (NRK); and the School of Public Health, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (OP).
MD
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Leora Zamir
From the Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (NG, LZ, OP); the Enforcement and Inspection Division, Israeli Ministry of Health, Jerusalem, Israel (AP); the Medical Division, Leumit Health Services, Tel-Aviv, Israel (NRK); the School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel (NRK); and the School of Public Health, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (OP).
MD
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Alina Poperno
From the Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (NG, LZ, OP); the Enforcement and Inspection Division, Israeli Ministry of Health, Jerusalem, Israel (AP); the Medical Division, Leumit Health Services, Tel-Aviv, Israel (NRK); the School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel (NRK); and the School of Public Health, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (OP).
MPH, B.Pharm, B.Sc
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Nathan R. Kahan
From the Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (NG, LZ, OP); the Enforcement and Inspection Division, Israeli Ministry of Health, Jerusalem, Israel (AP); the Medical Division, Leumit Health Services, Tel-Aviv, Israel (NRK); the School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel (NRK); and the School of Public Health, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (OP).
RPh, MHA, PhD
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Ora Paltiel
From the Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (NG, LZ, OP); the Enforcement and Inspection Division, Israeli Ministry of Health, Jerusalem, Israel (AP); the Medical Division, Leumit Health Services, Tel-Aviv, Israel (NRK); the School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel (NRK); and the School of Public Health, Hadassah-Hebrew University Medical Center, Jerusalem, Israel (OP).
MDCM, MSc, FRCPC
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References

  1. 1.↵
    1. Sergentanis TN,
    2. Zagouri F,
    3. Tsilimidos G,
    4. et al
    . Risk factors for multiple myeloma: a systematic review of meta-analyses. Clin Lymphoma Myeloma Leuk 2015;15:563–77.e1–3.
  2. 2.↵
    1. Landgren O,
    2. Waxman AJ
    . Multiple myeloma precursor disease. JAMA 2010;304:2397–404.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Kyle RA,
    2. Durie BGM,
    3. Rajkumar SV,
    4. et al
    . Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia 2010;24:1121–7.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Rajkumar SV,
    2. Dimopoulos MA,
    3. Palumbo A,
    4. et al
    . International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 2014;15:e538–48.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Durie BG,
    2. Salmon SE
    . A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 1975;36:842–54.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Greipp PR,
    2. San Miguel J,
    3. Durie BG,
    4. et al
    . International staging system for multiple myeloma. J Clin Oncol 2005;23:3412–20.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Bianchi G,
    2. Kyle RA,
    3. Colby CL,
    4. et al
    . Impact of optimal follow-up of monoclonal gammopathy of undetermined significance on early diagnosis and prevention of myeloma-related complications. Blood 2010;116:2019–25; quiz 2197.
    OpenUrlAbstract/FREE Full Text
  8. 8.↵
    1. Mateos M-V,
    2. Hernández M-T,
    3. Giraldo P,
    4. et al
    . Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma. N Engl J Med 2013;369:438–47.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Deyo RA,
    2. Rainville J,
    3. Kent DL
    . What can the history and physical examination tell us about low back pain? JAMA 1992;268:760–5.
    OpenUrlCrossRefPubMedWeb of Science
  10. 10.↵
    1. Kyle RA,
    2. Rajkumar SV
    . Multiple myeloma. N Engl J Med 2004;351:1860–73.
    OpenUrlCrossRefPubMedWeb of Science
  11. 11.↵
    1. Dobson CM,
    2. Russell AJ,
    3. Rubin GP
    . Patient delay in cancer diagnosis: what do we really mean and can we be more specific? BMC Health Serv Res 2014;14:387.
    OpenUrl
  12. 12.↵
    National Patient Safety Agency, Royal College of General Practitioners. Delayed diagnosis of cancer: thematic review. Data report, ref. no. 0968. London: NHS England; 2010. Available from: http://www.nrls.npsa.nhs.uk/resources/?EntryId45=69894. Accessed September 28, 2016.
  13. 13.↵
    1. Hill A,
    2. Elkin K,
    3. Davidson N
    . Delayed diagnosis of cancer in primary care: what do our complaints tell us? New Zealand: Health and Disability Commissioner; 2015. Available from: http://www.hdc.org.nz/publications/other-publications-from-hdc/articles/2015/delayed-diagnosis-of-cancer-in-primary-care-what-do-our-complaints-tell-us. Accessed September 28, 2016.
  14. 14.↵
    1. Green LA,
    2. Fryer GE,
    3. Yawn BP,
    4. Lanier D,
    5. Dovey SM
    . The ecology of medical care revisited. N Engl J Med 2001;344:2021–5.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Jarvik JG,
    2. Deyo RA
    . Diagnostic evaluation of low back pain with emphasis on imaging. Ann Intern Med 2002;137:586–97.
    OpenUrlCrossRefPubMedWeb of Science
  16. 16.↵
    1. Kariyawasan CC,
    2. Hughes DA,
    3. Jayatillake MM,
    4. Mehta AB
    . Multiple myeloma: causes and consequences of delay in diagnosis. QJM 2007;100:635–40.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Friese CR,
    2. Abel GA,
    3. Magazu LS,
    4. Neville BA,
    5. Richardson LC,
    6. Earle CC
    . Diagnostic delay and complications for older adults with multiple myeloma. Leuk Lymphoma 2009;50:392–400.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. van den Hoogen HM,
    2. Koes BW,
    3. van Eijk JT,
    4. Bouter LM
    . On the accuracy of history, physical examination, and erythrocyte sedimentation rate in diagnosing low back pain in general practice. A criteria-based review of the literature. Spine 1995;20:318–27.
    OpenUrlPubMedWeb of Science
  19. 19.↵
    1. Dispenzieri A,
    2. Kyle R,
    3. Merlini G,
    4. et al
    . International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia 2009;23:215–24.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.↵
    1. Dimopoulos M,
    2. Kyle R,
    3. Fermand J-P,
    4. et al
    . Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3. Blood 2011;117:4701–5.
    OpenUrlAbstract/FREE Full Text
  21. 21.↵
    1. Espersen F,
    2. Birgens HS,
    3. Hertz JB,
    4. Drivsholm A
    . Current patterns of bacterial infection in myelomatosis. Scand J Infect Dis 1984;16:169–73.
    OpenUrlCrossRefPubMedWeb of Science
  22. 22.↵
    1. Kyle RA,
    2. Gertz MA,
    3. Witzig TE,
    4. et al
    . Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003;78:21–33.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Fechtner K,
    2. Hillengass J,
    3. Delorme S,
    4. et al
    . Staging monoclonal plasma cell disease: comparison of the Durie-Salmon and the Durie-Salmon PLUS staging systems. Radiology 2010;257:195–204.
    OpenUrlCrossRefPubMed
  24. 24.↵
    1. Rajkumar SV,
    2. Kyle RA
    . Multiple myeloma: diagnosis and treatment. Mayo Clin Proc 2005;80:1371–82.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Abel GA,
    2. Friese CR,
    3. Neville BA,
    4. et al
    . Referrals for suspected hematologic malignancy: a survey of primary care physicians. Am J Hematol 2012;87:634–6.
    OpenUrlCrossRefPubMed
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The Journal of the American Board of Family     Medicine: 29 (6)
The Journal of the American Board of Family Medicine
Vol. 29, Issue 6
November-December 2016
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Presenting Signs of Multiple Myeloma and the Effect of Diagnostic Delay on the Prognosis
Neta Goldschmidt, Leora Zamir, Alina Poperno, Nathan R. Kahan, Ora Paltiel
The Journal of the American Board of Family Medicine Nov 2016, 29 (6) 702-709; DOI: 10.3122/jabfm.2016.06.150393

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Presenting Signs of Multiple Myeloma and the Effect of Diagnostic Delay on the Prognosis
Neta Goldschmidt, Leora Zamir, Alina Poperno, Nathan R. Kahan, Ora Paltiel
The Journal of the American Board of Family Medicine Nov 2016, 29 (6) 702-709; DOI: 10.3122/jabfm.2016.06.150393
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  • Clinical features and diagnosis of multiple myeloma: a population-based cohort study in primary care
  • Improving the diagnostic pathway in patients presenting with acute kidney injury secondary to de novo multiple myeloma: a short report
  • Excluding myeloma diagnosis using revised thresholds for serum free light chain ratios and M-protein levels
  • Quantifying intervals to diagnosis in myeloma: a systematic review and meta-analysis
  • Re: Presenting Signs of Multiple Myeloma and the Effect of Diagnostic Delay on the Prognosis
  • Bread and Butter of Family Medicine: Guidelines, Population Screening, Diagnostic Evaluations, and Practice Models
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Keywords

  • Anemia
  • Back Pain
  • Creatinine
  • Early Detection of Cancer
  • Electronic Health Records
  • Health Maintenance Organizations
  • Multiple Myeloma
  • Primary Health Care
  • Prognosis
  • Retrospective Studies
  • Weight Loss

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