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Research ArticleOriginal Research

Training to Use Motivational Interviewing Techniques for Depression: A Cluster Randomized Trial

Robert D. Keeley, Brian L. Burke, David Brody, Sona Dimidjian, Matthew Engel, Caroline Emsermann, Frank deGruy, Marshall Thomas, Ernesto Moralez, Steve Koester and Jessica Kaplan
The Journal of the American Board of Family Medicine September 2014, 27 (5) 621-636; DOI: https://doi.org/10.3122/jabfm.2014.05.130324
Robert D. Keeley
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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Brian L. Burke
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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David Brody
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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Sona Dimidjian
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
PhD
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Matthew Engel
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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Caroline Emsermann
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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Frank deGruy
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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Marshall Thomas
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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Ernesto Moralez
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
MPH
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Steve Koester
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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Jessica Kaplan
From the Department of Family Medicine (RDK, CE, FdG), the Department of Internal Medicine (DB), the Department of Psychiatry (MT), and the Department of Health and Behavioral Sciences (SK), University of Colorado, Denver; Denver Health, Denver, CO (RDK, DB, ME); the Department of Psychology, Fort Lewis College, Durango, CO (BLB); the Department of Psychology and Neuroscience, University of Colorado, Boulder (SD); and Emory University School of Medicine (JK).
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    Figure 1.

    Theoretical model of how motivational interviewing (MI) training influences patient treatment and health outcomes.

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    Figure 2.

    Flow diagram of primary care provider progress through the phases of the randomized trial. MI, motivational interviewing.

Tables

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    Table 1. Four-visit Episode of Care
    Baseline visit goals:
    • Build relationship using OARS*

    • Provide symptom feedback

      • ○ Ask permission

      • ○ Provide depressive symptom score

      • ○ Ask: “What do you think of this result?”

    • Elicit-Provide-Elicit**

    • Develop follow-up and action plan

    Follow-up visit goals:
    • Enhance treatment adherence with “rulers”***

    • Explore other relevant behavioral targets

    • Foster behavioral activation and problem solving

    • ↵* OARS: Open questions, Affirmations, Reflections, Summary statements.

    • ↵** Elicit-Provide-Elicit: A method of asking about current knowledge, providing information with permission, and asking patient to reflect on the new information. Goal is to elicit change talk.

    • ↵*** Rulers: 10 point scale of patient's confidence in and perceived importance of behavior change.

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    Table 2. Baseline Characteristics of the Provider and Patient Participants
    Characteristics*Intervention†Control‡
    Providersn = 10n = 11
        Age, years49.2 (7.6)47.4 (8.6)
        Female sex (n)68
        Ethnicity (n)
            White810
            Hispanic12
        Specialty (n)
            Internal medicine32
            Family medicine46
            Nurse practitioner22
            Physician's assistant11
        Years in practice16.8 (8.6)17.5 (8.8)
        Previous MI training (hours)1.1 (3.3)0.5 (0.8)
    Patients§n = 85n = 86
        Clusters (n)1011
        Age, years51.5 (7.9)45.3 (7.3)
        Female sex, %62.0 (31.1)67.8 (24.5)
        Race/ethnicity, %
            Non-Hispanic white17.6 (13.7)26.0 (14.6)
            Non-Hispanic black32.6 (34.8)43.2 (23.9)
            Hispanic38.2 (31.4)25.2 (26.4)
            Other11.7 (9.8)5.6 (7.7)
        Insurance, %
            Uninsured34.5 (20.3)46.4 (24.6)
            Private2.9 (7.1)2.7 (4.3)
            Public62.5 (21.9)49.8 (22.1)
        Household income <$10,000, %48.0 (20.7)51.7 (23.5)
        Employed39.9 (23.9)47.6 (14.1)
        Body mass index (kg/m2)31.5 (3.9)32.9 (3.3)
        Physical comorbidities‖2.3 (0.8)2.1 (1.0)
        PHQ-9 score15.6 (2.4)15.9 (1.8)
    • Data are mean (standard deviation) of participants unless stated otherwise.

    • ↵* The number of participating primary care physicians (PCPs) was distributed as follows: 2 clinics with 1 PCP, 1 with 2 PCPs, 3 with 4 PCPs, and 1 with 5 PCPs.

    • ↵† Motivational interviewing with standard management of depression training.

    • ↵‡ Standard management of depression training alone.

    • ↵§ Patient characteristics were analyzed by cluster. Data provided are per cluster.

    • ↵‖ Comorbid categories were derived from abstracting the electronic medical record of up to 8 common chronic diseases in the patient problem list, including arthritis, asthma, chronic pain, congestive heart failure, chronic obstructive pulmonary disease, coronary heart disease, diabetes, and obesity (body mass index ≥30 kg/m2).

    • PHQ-9, 9-item Patient Health Questionnaire.

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    Table 3. Comparison of Mean Scores for Provider- and Patient-level Outcomes by Randomization Arm
    Provider- and Patient-Level MeasuresIntervention* Mean or Proportion (SD) n = 85Control† Mean or Proportion (SD) (n = 86)P ValueAdjusted Odds Ratio or Cohen's d** (95% CI)
    Summary MI performance
        Rate of MI-consistent statements‡8.80 (4.16)6.98 (4.14).005d = 0.44 (0.13–0.74)
    Summary global rating
        Beginning spirit in MI Spirit (≥3.5)0.37 (1.01)0.15 (0.59).0833.28 (0.83–12.90)
    Provider treatment advice
        Recommendation for physical activity0.34 (0.54)0.19 (0.43).0532.21 (0.99–4.95)
        Prescription for antidepressant medication0.42 (0.53)0.38 (0.51).661.17 (0.59–2.30)
    Frequency of patient change talk
        Rate of all depression treatment-related‖ change talk‡0.90 (0.91)0.44 (0.90).001d = 0.51 (0.21–0.82)
        Rate of change talk specific to physical activity0.30 (0.51)0.10 (0.51).01d = 0.39 (0.09–0.70)
        Rate of change talk specific to antidepressant medication0.25 (0.47)0.15 (0.46).17d = 0.21 (−0.09 to 0.51)
    Treatment adherence
        Days physically active in past week,§ n¶3.05 (2.83)1.84 (2.75).007d = 0.42 (0.11–0.72)
        Filled prescription, %0.62 (0.17)0.56 (0.17).631.27 (0.48–3.34)
    • Data are number (%) of participants unless stated otherwise.

    • ↵* Motivational interviewing (MI) with standard management of depression training.

    • ↵† Standard management of depression training alone.

    • ↵‡ Mean rate of open questions, reflective statements, or MI-adherent statements per 10 minutes of the clinical encounter.

    • ↵§ Physical activity was ascertained on average 5.4 days (standard deviation, 3.3 days) after the index encounter.

    • ↵‖ Includes change talk regarding physical activity, antidepressant medication, specialty mental health counseling, and nonharmful behaviors the patient suggests might alleviate depressive symptoms.

    • ↵¶ Days in the previous week during which patient engaged in at least 30 minutes of physical activity.

    • ↵** Clinical effect sizes based on Cohen d values: 0.2, small; 0.5, medium; 0.8, large. Clinical effect sizes based on odds ratio (OR): 1.29, small; 1.88, medium; 2.79, large.44

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    Table 4. Provider Motivational Interviewing Treatment Integrity Technical and Relational Measures by Randomization Arm
    Mean (SD) by Treatment ArmP Value
    Intervention* (n = 85)Control† (n = 86)
    Visit time (seconds)1571 (480)1447 (545).056
    MI treatment integrity instrument component measure‡
        MI-adherent statements3.49 (3.29)2.01 (3.3).004
            Asking permission§‖0.75 (0.92)0.13 (0.92)<.0001
            Affirmations§‖1.07 (1.65)0.39 (1.64).007
            Emphasizing control‖0.31 (0.76)0.42 (0.76).34
            Support‖1.35 (1.91)1.08 (1.91).36
        MI nonadherent statements†3.14 (7.11)3.62 (7.05).66
            Advising1.24 (2.81)1.48 (2.79).58
            Confronting1.10 (3.23)1.30 (3.20).68
            Directing0.75 (1.80)0.84 (1.80).76
    Percent MI-Adherent56.04 (63.41)37.69 (61.62).07
    Beginning proficiency for Percent MI-Adherent (n/N)¶0/100/10—
    Questions
        Closed29.85 (20.76)25.93 (20.65).22
        Open§‖5.87 (3.87)4.5 (3.87).02
    Open questions (%)¶16.97 (10.59)15.37 (10.58).32
    Beginning proficiency for open questions (n/N)0/100/10—
    Reflections
        Simple‖6.73 (6.60)6.48 (6.57).80
        Complex§‖2.91 (3.38)1.74 (3.38).03
    Complex reflection (%)¶28.92 (33.96)19.41 (33.62).07
    Beginning proficiency for complex reflections (n/N)2/100/10.47
    Reflection-to-question ratio¶
        Giving information20.16 (11.78)20.86 (11.75).70
    Global ratings
        Evocation3.00 (2.08)2.52 (2.07).127
        Evocation: beginning proficiency¶3/100/10.21
        Collaboration3.13 (2.23)2.74 (2.21).25
        Collaboration: beginning proficiency¶3/102/101.00
        Autonomy support3.21 (1.75)2.79 (1.74).11
        Autonomy support: beginning proficiency1/103/10.58
        Direction4.40 (1.28)3.97 (1.28).03
        Direction: beginning proficiency‡10/108/10.47
        Empathy3.22 (2.03)2.82 (2.01).20
        Empathy: beginning proficiency3/102/101.00
    • Data are number (%) of participants unless stated otherwise.

    • ↵* Motivational interviewing (MI) with standard management of depression training.

    • ↵† Standard management of depression training alone.

    • ↵‡ Language counts, frequencies, and global scores are derived from clustered analyses. For standardization purposes the language counts are adjusted for encounter length (seconds).

    • ↵§ Motivational Interviewing Treatment Integrity (MITI) component was a focus in >1 MI classroom training.

    • ↵‖ MITI component included in composite frequency of MI-consistent language measure.

    • ↵¶ MITI ratio definitions: percentage adherent to MI = MI-adherent statements/(MI-adherent statements + MI-nonadherent statements); percentage of OC = open questions/(open questions + closed questions); percentage of complex reflections = complex reflections/(complex reflections + simple reflections); reflection-to-question ratio = (simple + complex reflections) / (closed + open questions).

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    Table 5. Association between Motivational Interviewing (MI) Trainings Attended and MI Performance and Global Rating
    MI MeasureTraining Sessions
    3 Sessions (n = 47)2 Sessions (n = 21)1 Session (n = 17)Control (n = 86)
    MI performance score
        MI-consistent statement rate (per 10 minutes of the encounter) (95% CI)9.59 (8.5–10.7)8.55 (7.0–10.2)6.92 (5.1–8.7)6.96 (6.2–7.8)
        3 MI training sessions vs comparator, Cohen d (95% CI), P value0.28 (−0.21 to 0.77), .2900.72 (0.21–1.24), .0120.71 (0.36–1.06), <.001
    Global Rating
        Beginning Spirit in MI Spirit (3.5 or higher) (95% CI)0.49 (0.22–0.77)0.25 (0.04–0.72)0.18 (0.02–0.67)0.15 (0.06–0.32)
        3 MI training sessions vs comparator, OR (95% CI), P value2.89 (0.27–31.21), .3804.27 (0.34–53.37), .265.6 (1.13–27.89), .036
    • Clinical effect sizes with Cohen's d: 0.2, small; 0.5, medium; 0.8, large. Clinical effect sizes with odds ratio (OR): 1.29, small; 1.88, medium; 2.79, large.44

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    Table 6. Components of Motivational Interviewing (MI)
    Components1,2DefinitionExamples/Rating Scheme
    Relational domain
        MI SpiritMI spirit is exemplified by collaboration in all areas of MI practice; eliciting and respecting the client's ideas, perceptions, and opinions; eliciting and reinforcing the client's autonomy and choices; and accepting the client's decisions.
    The spirit of MI has 3 foundations:
    1. Collaboration: Collaboration between the primary care provider and the patient or “client” builds a trusting relationship.

    2. Evocation:- Helping the client to voice their own ideas and reasons for change.

    3. Autonomy/support: The provider supports the patient as the agent of change, and the patient is responsible for following through or not. The provider is supportive of the patient regardless of whether and how they decide to change.

    Average of global scores of evocation, collaboration, and autonomy/support (scales of 1 to 5; percentage highest; average, 3); providers score high on collaboration when they negotiate with the client, respect the client's ideas about how change can occur, avoid persuasion, and focus on supporting the client's own concerns and ideas. Confrontational, authoritative, and rigid providers score low on collaboration.
    Higher scores on evocation result when the provider draws out the client's ideas as opposed to instilling knowledge, insights, and advice. Lower scores are ascribed to providers who show little interest in the client's perspective or display cynicism about prospects for change.
    Higher scores for autonomy/support occur when the provider readily accepts the client's decisions not to change at that particular moment. This provider recognizes that critical factors predicting change reside within the client. Low autonomy/support is typified by an urgency to change and lack of acceptance of the client's capability to decide to change or not; client freedom of choice and self-determination is not recognized in this instance.
        EmpathyExpressing empathy includes expressing understanding of the patient's lived experience or seeing, feeling, and experiencing the world through the patient's eyes.Range 1 to 5 (higher is better; average, 3); high empathy is characterized by the provider showing active interest in the client's perspectives, including situation, meaning, perceptions, and feelings. Low empathy is characterized by a lack of interest in the client's perspectives and experiences. Probing for factual information and pursuing an agenda are examples of low empathy.
    Technical domain
        MI-adherent statementsThis category is used to capture particular interviewer behaviors that are consistent with a motivational interviewing approach.
    Affirmation: The provider says something positive or complementary to the client; may be in the form of appreciation, confidence, or reinforcement. The provider comments on the client's strengths or efforts.
    Emphasize autonomy: The provider recognizes the client's freedom of choice, autonomy, and ability to decide.
    Asking permission before giving advice or permission: Asking what the client already knows or has already been told about a topic before giving advice or information.
    Support: The provider makes a statement that takes on a compassionate, sympathetic, supportive, or agreeing quality.
    “It takes courage to come in and talk about depression.” (Affirm)
    “You've got a point there.” (Emphasizing the client's control)
    “May I share some information about antidepressant medications?” (Ask permission)
    “Well, there is really a lot going on for you right now.” (Support)
        Open-ended questionsAn open question is coded when the interviewer asks a question that allows a wide range of possible answers. The question may seek information, invite the client's perspective, or encourage self-exploration. The open question allows the option of surprise for the questioner.
    “Tell me more” statements are coded as open questions unless the tone and context clearly indicate a direct or confront code.
    “What is your take on that?” (Open question)
        Reflective statements (simple and complex)This category is meant to capture reflective listening statements made by the provider in response to client statements. A reflection may introduce new meaning or material, but it essentially captures and returns to clients something about what they have just said.
    Simple: Simple reflections typically convey understanding or facilitate client/provider exchanges. These reflections add little or no meaning (or emphasis) to what clients have said.
    Complex: Complex reflections typically add substantial meaning or emphasis to what the client has said. These reflections serve the purpose of conveying a deeper or more complex picture of what the client has said. Sometimes the provider may choose to emphasize a particular part of what the client has said to make a point or take the conversation in a different direction.
    “You are determined to start an antidepressant medication.” (Simple reflection)
    “On the one hand you perceive potential benefit from the medicine, and on the other hand you are terrified of getting addicted.” (Complex reflection)
        MI-consistent languageMI adherent statements + reflections + open questions
        RulersThe confidence and importance rulers invite the client to rate their confidence or importance on a 0 to 10 scale regarding making a target behavior change.The provider may implement the rulers to evoke client “change talk,” or language toward making a specific behavior change. When the client provides a number, eg, “5,” the provider can ask, “Why did you say ‘5’ and not ‘2’?” which evokes reasons for change. Alternatively, the provider might say, “What would it take to raise the ‘5’ to an ‘8’?,” which also evokes change talk. The process involves 2 open questions.
        Ask–provide–ask or elicit–provide–elicitThe ask—provide–ask tool is an MI-consistent approach to sharing information. First, the provider asks permission to share information, then with permission shares information, and follows by asking the client what they think or how they are reacting to the information. A variant is the elicit–provide–elicit approach for garnering learning about a client's thoughts or perspectives, sharing information or one's perspectives with permission, then eliciting more of the client's perspectives and change talk.The provider firsts asks permission to share information by asking, for example, “Would you be interested in hearing more about possible treatment options for depression?” If the patient assents, the provider can then provide information, then ask about or elicit the client's thoughts, eg, by asking “What do you think about those options?”
        Elaborate, affirm, reflect, summarizeWhen a provider recognizes change talk, the goal is to reinforce the change talk. The provider then asks the patient to elaborate on what they meant using evocative questions, affirms the patient's statements toward positive change, and reflects the change talk. This approach often elicits more change talk. The provider then summarizes the patient's change talk, any plans to change, and strengths.
        Giving informationIf the provider gives information, educates, provides feedback, or discloses personal information, it is considered “giving information.”An example would be feedback from a depressive symptom scale. “You scored a 19 on the depressive symptoms scale, which is consistent with moderately severe depressive symptoms.”
        Closed questionsClosed questions can be answered with a “yes” or “no.”“Have you been taking your antidepressant medication as prescribed?”
        MI-nonadherent statementsAdvising, directing, confronting
    Advising without permission involves uninvited advice, suggestions, or a solution.
    Direct- involves a command, direction, or order.
    A confrontation involves expert-like responses that have a particular negative/parental quality, an uneven power relationship accompanied by disapproval, disagreement, or negativity.
    The provider may directly disagree, argue, correct, shame, blame, seek to persuade, criticize, judge, label, moralize, ridicule, or question the client's honesty.
    “I'd recommend that you start an antidepressant medication.” (Advising)
    “At this point, you really need to get some therapy.” (Direct)
    “It's evident to me that you are not taking your medicine.” (Confrontation)
    • View popup
    Table 7. Kappa Coefficients for Dichotomous and Ordinal Measures
    Measureκ Value*
    Prescription for antidepressant provided0.87
    Recommendation of physical activity0.44
    Evocation0.61
    Autonomy/support0.72
    Collaboration0.72
    Direction0.69
    Empathy0.74
    • ↵* Using normal approximation to test H0: no agreement.

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    Table 8. Intraclass Correlation Coefficients (ICCs) for Continuous Measures
    MeasureICC
    fMICO (rate)0.74
    MI spirit0.54
    MI-adherent statements, %0.61
    Open questions, %0.70
    Complex reflections, %0.45
    Giving information (adjusted for time)0.79
    Change talk pertaining to ways to handle depression (rate)0.83
    Change talk around medications for depression (rate)0.85
    Change talk around physical activity (rate)0.76
    • fMICO, frequency of MI-consistent language; MI, motivational interviewing.

    • View popup
    Table 9. Coefficients of Intracluster Correlation*
    MeasureBy Provider
    Rate of MI-consistent language0.009
    MI spirit (1–5)0.48
    Beginning proficiency in MI spirit (≥3.5)0.22
    Prescription for antidepressant provided0.00
    Recommendation of physical activity0.0005
    Change talk regarding depression treatment frequency0.021
    Change talk specific to antidepressant medication frequency0.010
    Change talk specific to physical activity frequency0.0036
    Physical activity0.014
    Filled antidepressant medication0.056
    • ↵* Coefficients of intracluster correlation are considered small (<0.05), medium (<0.15), or large (>0.15).43

    • MI, motivational interviewing.

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The Journal of the American Board of Family     Medicine: 27 (5)
The Journal of the American Board of Family Medicine
Vol. 27, Issue 5
September-October 2014
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Training to Use Motivational Interviewing Techniques for Depression: A Cluster Randomized Trial
Robert D. Keeley, Brian L. Burke, David Brody, Sona Dimidjian, Matthew Engel, Caroline Emsermann, Frank deGruy, Marshall Thomas, Ernesto Moralez, Steve Koester, Jessica Kaplan
The Journal of the American Board of Family Medicine Sep 2014, 27 (5) 621-636; DOI: 10.3122/jabfm.2014.05.130324

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Training to Use Motivational Interviewing Techniques for Depression: A Cluster Randomized Trial
Robert D. Keeley, Brian L. Burke, David Brody, Sona Dimidjian, Matthew Engel, Caroline Emsermann, Frank deGruy, Marshall Thomas, Ernesto Moralez, Steve Koester, Jessica Kaplan
The Journal of the American Board of Family Medicine Sep 2014, 27 (5) 621-636; DOI: 10.3122/jabfm.2014.05.130324
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Keywords

  • Depressive Disorder
  • Medical Education
  • Motivational Interviewing
  • Patient Adherence
  • Randomized Controlled Trial

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