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Research ArticleOriginal Research

Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis

Maggie Thomson, Renee Corbin and Lawrence Leung
The Journal of the American Board of Family Medicine January 2014, 27 (1) 115-122; DOI: https://doi.org/10.3122/jabfm.2014.01.130167
Maggie Thomson
the Department of Family Medicine (MT, LL) and the Centre of Studies in Primary Care (RC, LL), Queen's University, Kingston, Ontario, Canada.
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Renee Corbin
the Department of Family Medicine (MT, LL) and the Centre of Studies in Primary Care (RC, LL), Queen's University, Kingston, Ontario, Canada.
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Lawrence Leung
the Department of Family Medicine (MT, LL) and the Centre of Studies in Primary Care (RC, LL), Queen's University, Kingston, Ontario, Canada.
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Abstract

Background: Nausea and vomiting in early pregnancy (NVEP) is commonly encountered in family medicine. Ginger (Zingiber officinale) is a popular nonpharmacological treatment but consensus of its use is lacking.

Methods: We conducted a meta-analysis of clinical trials using ginger for NVEP as published in PubMed and EMBASE, CINAHL, Cochrane Library, and all EBM reviews. Studies satisfying 3 criteria were selected: (1) randomized placebo-controlled design; (2) use of ginger or Z. officinale; and (3) extractable data on improvement in NVEP. Data were synthesized into pooled odd ratios based on the random effects model, and results were tabulated with the aid of Forest plots.

Results: We identified 135 potentially relevant records; only 6 studies met the final criteria. Of the total 508 subjects, 256 and 252 subjects were randomly assigned to receive ginger and placebo, respectively. The use of ginger (∼1 g daily) for at least 4 days is associated with a 5-fold likelihood of improvement in NVEP. Heterogeneity among the clinical studies were acknowledged in the final interpretation of results.

Conclusions: Despite the widespread use of ginger in the diet, its clinic value and safety profile in treating NVEP is still unknown. Our meta-analysis suggests that ginger is an effective nonpharmacological treatment for NVEP.

  • Alternative Medicine
  • Complementary Medicine
  • Pregnancy
  • Prenatal Care
  • Primary Health Care
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The Journal of the American Board of Family     Medicine: 27 (1)
The Journal of the American Board of Family Medicine
Vol. 27, Issue 1
January-February 2014
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Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis
Maggie Thomson, Renee Corbin, Lawrence Leung
The Journal of the American Board of Family Medicine Jan 2014, 27 (1) 115-122; DOI: 10.3122/jabfm.2014.01.130167

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Effects of Ginger for Nausea and Vomiting in Early Pregnancy: A Meta-Analysis
Maggie Thomson, Renee Corbin, Lawrence Leung
The Journal of the American Board of Family Medicine Jan 2014, 27 (1) 115-122; DOI: 10.3122/jabfm.2014.01.130167
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  • Article
    • Abstract
    • Epidemiology, Risk Factors, and Pathogenesis of NVEP
    • Diagnosis and Treatment of NVEP
    • Ginger and Its Medicinal Effects
    • Methods
    • Results
    • Discussion
    • Conclusions
    • Appendix: PRISMA Flow Diagram
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  • Alternative Medicine
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