Review ArticleClinical Review

Asthma, Chronic Obstructive Pulmonary Disease (COPD), and the Overlap Syndrome

Mohammad Obadah Nakawah, Clare Hawkins and Farouk Barbandi
The Journal of the American Board of Family Medicine July 2013, 26 (4) 470-477; DOI: https://doi.org/10.3122/jabfm.2013.04.120256

References

  1. 1.↵
    Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Heart, Lung, and Blood Institute, National Asthma Education and Prevention Program. Bethesda, MD: U.S. Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute; 2007.
  2. 2.↵
    Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease NHLBI/WHO Workshop Report. Updated 2011. Available from: http://www.goldcopd.org. Accessed February 15, 2013.
  3. 3.↵
    1. Douwes J,
    2. Gibson P,
    3. Pekkanen J,
    4. Pearce N
    . Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002;57:643-8.
    OpenUrlAbstract/FREE Full Text
  4. 4.↵
    1. Cowan DC,
    2. Cowan JO,
    3. Palmay R,
    4. Williamson A,
    5. Taylor DR
    . Effects of steroid therapy on inflammatory cell subtypes in asthma. Thorax 2010;65:384-90.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Chalmers GW,
    2. Macleod KJ,
    3. Little SA,
    4. Thomson LJ,
    5. McSharry CP,
    6. Thomson NC
    . Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002;57:226-30.
    OpenUrlAbstract/FREE Full Text
  6. 6.↵
    1. Chaudhuri R,
    2. Livingston E,
    3. McMahon AD,
    4. Thomson L,
    5. Borland W,
    6. Thomson NC
    . Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 2003;168:1308-11.
    OpenUrlCrossRefPubMedWeb of Science
  7. 7.↵
    1. Chanez P,
    2. Vignola AM,
    3. O'Shaugnessy T,
    4. et al
    . Corticosteroid reversibility in COPD is related to features of asthma. Am J Respir Crit Care Med 1997;155:1529-34.
    OpenUrlPubMedWeb of Science
  8. 8.↵
    1. O'Byrne PM,
    2. Pedersen S,
    3. Lamm CJ,
    4. Busse WW
    ; START Investigators Group. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med 2009;179:19-24.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Sapey E,
    2. Stockley RA
    . COPD exacerbations. 2: aetiology. Thorax 2006;61:250-8.
    OpenUrlAbstract/FREE Full Text
  10. 10.↵
    1. Hamid Q,
    2. Tulic MK
    . New insights into the pathophysiology of the small airways in asthma. Ann Thorac Med 2007;2:28-33.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Hogg JC,
    2. Chu F,
    3. Utokaparch S,
    4. et al
    . The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645-53.
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.↵
    1. Sköld CM
    . Remodeling in asthma and COPD-differences and similarities. Clin Respir J. 2010;4(Suppl 1):20-7.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Vestbo J,
    2. Hansen EF
    . Airway hyperresponsiveness and COPD mortality. Thorax 2001;56(Suppl 2): ii11-4.
    OpenUrlFREE Full Text
  14. 14.↵
    1. Postma DS,
    2. Kerstjens HAM
    . Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998;158:S187-92.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Scichilone N,
    2. Battaglia S,
    3. La Sala A,
    4. Bellia V
    . Clinical implications of airway hyper-responsiveness in COPD. Int J Chron Obstruct Pulmon Dis 2006;1:49-60.
    OpenUrlPubMed
  16. 16.↵
    1. Brutsche MH,
    2. Downs SH,
    3. Schindler C,
    4. et al
    . Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA Cohort Study. Thorax 2006;61:671-7.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Gibson PG,
    2. Simpson JL
    . The overlap syndrome of asthma and COPD: what are its features and how important is it? BMJ 2009;64:728-35.
    OpenUrl
  18. 18.↵
    1. Soriano JB,
    2. Davis KJ,
    3. Coleman B,
    4. Visick G,
    5. Mannino D,
    6. Pride NB
    . The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest 2003;124:474-81.
    OpenUrlCrossRefPubMedWeb of Science
  19. 19.↵
    1. Fabbri LM,
    2. Romagnoli M,
    3. Corbetta L,
    4. et al
    . Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003;167:418-24.
    OpenUrlCrossRefPubMedWeb of Science
  20. 20.↵
    1. Panettieri RA Jr.,
    2. Covar R,
    3. Grant E,
    4. Hillyer EV,
    5. Bacharier L
    . Natural history of asthma: persistence versus progression-does the beginning predict the end? J Allergy Clin Immunol 2008;121:607-13.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995;152:S77-121.
    OpenUrl
  22. 22.↵
    1. Rasmussen F,
    2. Taylor DR,
    3. Flannery EM,
    4. et al
    . Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood. Am J Respir Crit Care Med 2002;165:1480-8.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Orie NGM
    . The Dutch hypothesis. Chest 2000;117:299.
    OpenUrl
  24. 24.↵
    1. Fanta CH,
    2. Rossing TH,
    3. McFadden ER Jr.
    . Glucocorticoids in acute asthma. A critical controlled trial. Am J Med 1983;74:845-51.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Niewoehner DE,
    2. Erbland ML,
    3. Deupree RH,
    4. et al
    . Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. Department of Veterans Affairs Cooperative Study Group. N Engl J Med 1999;340:1941-7.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.↵
    1. Bach PB,
    2. Brown C,
    3. Gelfand SE,
    4. et al
    . Management of acute exacerbations of chronic obstructive pulmonary disease: a summary and appraisal of published evidence. Ann Intern Med 2001;134:600-20.
    OpenUrlCrossRefPubMedWeb of Science
  27. 27.↵
    1. Ram FS,
    2. Rodriguez-Roisin R,
    3. Granados-Navarrete A,
    4. Garcia-Aymerich J,
    5. Barnes NC
    . Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2006;(2):CD004403.
  28. 28.↵
    1. Rothberg MB,
    2. Pekow PS,
    3. Lahti M,
    4. Brody O,
    5. Skiest DJ,
    6. Lindenauer PK
    . Antibiotic therapy and treatment failure in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease. JAMA 2010;303:2035-42.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Koutsoubari I,
    2. Papaevangelou V,
    3. Konstantinou GN,
    4. et al
    . Effect of clarithromycin on acute asthma exacerbations in children: an open randomized study. Pediatr Allergy Immunol 2012;23:385-90.
    OpenUrlPubMed
  30. 30.↵
    1. Hahn DL,
    2. Grasmick M,
    3. Hetzel S,
    4. Yale S
    . Azithromycin for bronchial asthma in adults: an effectiveness trial. J Am Board Fam Med 2012;25:442-59.
    OpenUrlAbstract/FREE Full Text
  31. 31.↵
    1. Albert RK,
    2. Connett J,
    3. Bailey WC,
    4. et al
    . Zithromycin for prevention of exacerbations of COPD. N Engl J Med 2011;365:689-98.
    OpenUrlCrossRefPubMedWeb of Science
  32. 32.↵
    1. Keatings VM,
    2. Jatakanon A,
    3. Worsdell YM,
    4. Barnes PJ
    . Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997;155:542-8.
    OpenUrlCrossRefPubMedWeb of Science
  33. 33.↵
    1. Calverley PM,
    2. Anderson JA,
    3. Celli B,
    4. et al
    . Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med 2007;356:775-89.
    OpenUrlCrossRefPubMedWeb of Science
  34. 34.↵
    1. Leigh R,
    2. Pizzichini MM,
    3. Morris MM,
    4. Maltais F,
    5. Hargreave FE,
    6. Pizzichini E
    . Stable COPD: predicting benefit from high-dose inhaled corticosteroid treatment. Eur Respir J 2006;27:964-71.
    OpenUrlAbstract/FREE Full Text
  35. 35.↵
    1. Sin DD,
    2. McAlister FA,
    3. Man SF,
    4. Anthonisen NR
    . Contemporary management of chronic obstructive pulmonary disease: scientific review. JAMA 2003;290:2301-12.
    OpenUrlCrossRefPubMedWeb of Science
  36. 36.↵
    1. Man SF,
    2. McAlister FA,
    3. Anthonisen NR,
    4. Sin DD
    . Contemporary management of chronic obstructive pulmonary disease: clinical applications. JAMA 2003;290:2313-6.
    OpenUrlCrossRefPubMedWeb of Science
  37. 37.↵
    1. Chhabra SK,
    2. Bhatnagar S
    . Comparison of bronchodilator responsiveness in asthma and chronic obstructive pulmonary disease. Indian J Chest Dis Allied Sci 2002;44:91-7.
    OpenUrlPubMed
  38. 38.↵
    1. Donohue JF
    . Therapeutic responses in asthma and COPD-bronchodilators. Chest 2004;126(2 Suppl):125S-37S; discussion 159S-61S.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. Shrestha M,
    2. O'Brien T,
    3. Haddox R,
    4. et al
    . Decreased duration of emergency department treatment of chronic obstructive pulmonary disease exacerbations with the addition of ipratropium bromide to β-agonist therapy. Ann Emerg Med 1991;20:1206-9.
    OpenUrlCrossRefPubMedWeb of Science
  40. 40.↵
    1. Rodrigo GJ,
    2. Castro-Rodriguez JA
    . Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta-analysis. Thorax 2005;60:740-6.
    OpenUrlAbstract/FREE Full Text
  41. 41.↵
    1. Chhabra SK,
    2. Pandey KK
    . Comparison of acute bronchodilator effects of inhaled ipratropium bromide and salbutamol in bronchial asthma. J Asthma 2002;39:375-81.
    OpenUrlCrossRefPubMedWeb of Science
  42. 42.↵
    1. Peters SP,
    2. Kunselman SJ,
    3. Icitovic N,
    4. et al
    . Tiotropium bromide step-up therapy for adults with uncontrolled asthma: a randomized trial. N Engl J Med 2010;363:1715-26.
    OpenUrlCrossRefPubMedWeb of Science
  43. 43.↵
    1. Kerstjens HA,
    2. Disse B,
    3. Schröder-Babo W,
    4. et al
    . Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial. J Allergy Clin Immunol 2011;128:308-14.
    OpenUrlCrossRefPubMedWeb of Science
  44. 44.↵
    1. Bateman ED,
    2. Kornmann O,
    3. Schmidt P,
    4. Pivovarova A,
    5. Engel M,
    6. Fabbri LM
    . Tiotropium is noninferior to salmeterol in maintaining improved lung function in B16-Arg/Arg patients with asthma. J Allergy Clin Immunol 2011;128:315-22.
    OpenUrlCrossRefPubMedWeb of Science
  45. 45.↵
    1. Westby M,
    2. Benson M,
    3. Gibson P
    . Anticholinergic agents for chronic asthma in adults. Cochrane Database Syst Rev 2004;(3):CD003269.
  46. 46.↵
    1. Braun SR,
    2. Levy SF
    . Comparison of ipratropium bromide and albuterol in chronic obstructive pulmonary disease: a three-center study. Am J Med 1991;91:28S-32S.
    OpenUrlCrossRefPubMed
  47. 47.↵
    1. Niewoehner DE,
    2. Rice K,
    3. Cote C,
    4. et al
    . Prevention of exacerbations of chronic obstructive pulmonary disease with tiotropium, a once-daily inhaled anticholinergic bronchodilator: a randomized trial. Ann Intern Med 2005;143:317-26.
    OpenUrlCrossRefPubMedWeb of Science
  48. 48.↵
    1. Donohue JF,
    2. van Noord JA,
    3. Bateman ED,
    4. et al
    . A 6-month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002;122:47-55.
    OpenUrlCrossRefPubMedWeb of Science
  49. 49.↵
    In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone. An 85-day multicenter trial. COMBIVENT Inhalation Aerosol Study Group. Chest 1994;105:1411-9.
    OpenUrlCrossRefPubMedWeb of Science
  50. 50.↵
    1. Nichols J
    . Combination inhaled bronchodilator therapy in the management of chronic obstructive pulmonary disease. Pharmacotherapy 2007;27:447-54.
    OpenUrlCrossRefPubMed
Back to top

In this issue

Print
Download PDF
Article Alerts
Email Article
Citation Tools

Jump to section

Keywords