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Misconception Fact Bioidentical hormones are natural. Bioidentical refers to structure; natural refers to source. Bioidentical hormones are custom-compounded. Custom-compounding is one way to obtain bioidentical hormones. FDA-approved drugs are another. Bioidentical hormones are safe hormones. All hormones can cause side effects. A “completely safe” hormone does not exist. Conventional/traditional hormones are synthetic hormones. Conventional hormones may be synthetic or bioidentical. The choice of prescription depends on patient and physician preferences. FDA, US Food and Drug Administration.