Research ArticleOriginal Research
Acanthosis Nigricans: High Prevalence and Association with Diabetes in a Practice-based Research Network Consortium—A PRImary care Multi-Ethnic Network (PRIME Net) Study
Alberta S. Kong, Robert L. Williams, Robert Rhyne, Virginia Urias-Sandoval, Gina Cardinali, Nancy F. Weller, Betty Skipper, Robert Volk, Elvan Daniels, Bennett Parnes, Laurie McPherson and ; on behalf of PRIME Net Clinicians
The Journal of the American Board of Family
Medicine July 2010, 23 (4) 476-485; DOI: https://doi.org/10.3122/jabfm.2010.04.090221
Alberta S. Kong
MD, MPH
Robert L. Williams
MD, MPH
Robert Rhyne
MD
Virginia Urias-Sandoval
BA
Gina Cardinali
MSW
Nancy F. Weller
DrPH
Betty Skipper
PhD
Robert Volk
PhD
Elvan Daniels
MD
Bennett Parnes
MD
References
- ↵Knowler W, Barrett-Connor E, Fowler S, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393–403.
- ↵Drobac S, Brickman W, Smith T, Binns HJ. Evaluation of a type 2 diabetes screening protocol in an urban pediatric clinic. Pediatrics 2004; 114: 141–8.
- ↵Hud JA Jr, Cohen JB, Wagner JM, Cruz PD Jr. Prevalence and significance of acanthosis nigricans in an adult obese population. Arch Dermatol 1992; 128: 941–4.
- ↵Kobaissi HA, Weigensberg MJ, Ball GD, Cruz ML, Shaibi GQ, Goran MI. Relation between acanthosis nigricans and insulin sensitivity in overweight Hispanic children at risk for type 2 diabetes. Diabetes Care 2004; 27: 1412–6.
- ↵Mukhtar Q, Cleverley G, Voorhees RE, McGrath JW. Prevalence of acanthosis nigricans and its association with hyperinsulinemia in New Mexico adolescents. J Adolesc Health 2001; 28: 372–6.
- Stoddart ML, Blevins KS, Lee ET, Wang W, Blackett PR. Association of acanthosis nigricans with hyperinsulinemia compared with other selected risk factors for type 2 diabetes in Cherokee Indians: the Cherokee Diabetes Study. Diabetes Care 2002; 25: 1009–14.
- Stuart CA, Pate CJ, Peters EJ. Prevalence of acanthosis nigricans in an unselected population. Am J Med 1989; 87: 269–72.
- Stuart CA, Smith MM, Gilkison CR, Shaheb S, Stahn RM. Acanthosis Nigricans among Native Americans: an indicator of high diabetes risk. Am J Public Health 1994; 84: 1839–42.
- ↵Burke JP, Hale DE, Hazuda HP, Stern MP. A quantitative scale of acanthosis nigricans. Diabetes Care 1999; 22: 1655–9.
- ↵Stuart CA, Gilkison CR, Smith MM, Bosma AM, Keenan BS, Nagamani M. Acanthosis nigricans as a risk factor for non-insulin dependent diabetes mellitus. Clin Pediatr (Phila) 1998; 37: 73–9.
- ↵Kong A, Williams R, Smith M, et al. Acanthosis nigricans and diabetes risk factors: prevalence in young persons seen in Southwestern US primary care practices. Ann Fam Med 2007; 5: 202–8.
- ↵Brickman W, Binns HJ, Jovanovic B, Kolesky S, Mancini A, Metzger B. Acanthosis nigricans: a common finding in overweight youth. Pediatr Dermatol 2007; 24: 601–6.
- ↵University of New Mexico Health Sciences Center. Primary Care Multiethnic Network [homepage]. Available at http://hsc.unm.edu/som/primenet/. Accessed 15 May 2010.
- ↵Binns HJ, Lanier D, Pace WD, et al. Describing primary care encounters: the Primary Care Network Survey and the National Ambulatory Medical Care Survey. Ann Fam Med 2007; 5: 39–47.
- ↵University of New Mexico Health Sciences Center. Appendix 9. Diabetes Health History Survey. Available at http://hsc.unm.edu/som/primenet/documents/pdf/AN_Health_History_survey.pdf. Accessed 15 May 2010.
- ↵Williams R, McPherson L, Kong A, Skipper B, Weller N. Internet-based training in a practice-based research network consortium: a report from the Primary Care Multiethnic Network (PRIME Net). J Am Board Fam Med 2009; 22: 446–52.
- ↵University of New Mexico Health Sciences Center. PRIME-Net Acanthosis nigricans CME. Available at http://hsc.unm.edu/som/primenet/an_cme.shtml. Accessed 15 May 2010.
- ↵Spiegelman D, Hertzmark E. Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol 2005; 162: 199–200.
- ↵
- Yamazaki H, Ito S, Yoshida H. Acanthosis nigricans is a reliable cutaneous marker of insulin resistance in obese Japanese children. Pediatr Int 2003; 45: 701–5.
- ↵Bonet B, Viana M, Sanchez-Vera I, Quintanar A, Martinez J, Espino M. Adipose tissue and liver lipid metabolism in obese children: role of the body mass index and the presence of acanthosis nigricans. Diabet Med 2007; 24: 1190–8.
- ↵Guran T, Turan S, Akcay T, Bereket A. Significance of acanthosis nigricans in childhood obesity. J Paediatr Child Health 2008; 44: 338–41.
- ↵Fareau G, Maldonado M, Oral E, Balasubramanyam A. Regression of acanthosis nigricans correlates with disappearance of anti-insulin receptor autoantibodies and achievement of euglycemia in type B insulin resistance syndrome. Metabolism 2006; 56: 670–5.
- ↵
- ↵Sloane PD, Dolor RJ, Halladay J. Increasing the role of practice networks in medical research. J Am Board Fam Med 2009; 22: 348–51.
In this issue
Acanthosis Nigricans: High Prevalence and Association with Diabetes in a Practice-based Research Network Consortium—A PRImary care Multi-Ethnic Network (PRIME Net) Study
Alberta S. Kong, Robert L. Williams, Robert Rhyne, Virginia Urias-Sandoval, Gina Cardinali, Nancy F. Weller, Betty Skipper, Robert Volk, Elvan Daniels, Bennett Parnes, Laurie McPherson
The Journal of the American Board of Family
Medicine Jul 2010, 23 (4) 476-485; DOI: 10.3122/jabfm.2010.04.090221
Acanthosis Nigricans: High Prevalence and Association with Diabetes in a Practice-based Research Network Consortium—A PRImary care Multi-Ethnic Network (PRIME Net) Study
Alberta S. Kong, Robert L. Williams, Robert Rhyne, Virginia Urias-Sandoval, Gina Cardinali, Nancy F. Weller, Betty Skipper, Robert Volk, Elvan Daniels, Bennett Parnes, Laurie McPherson
The Journal of the American Board of Family
Medicine Jul 2010, 23 (4) 476-485; DOI: 10.3122/jabfm.2010.04.090221
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