Effect of Antibiotics on Vulvovaginal Candidiasis: A MetroNet Study

Article Figures & Data

Table 1.

Demographic and Health Characteristics of Study Sample by Treatment Group

Characteristics	Antibiotic (n = 44) (n [%])	Control (n = 36) (n [%])	P
Age in years			.79
18–35	18 (41.9)	12 (34.3)
36–50	21 (48.8)	20 (57.1)
≥50	4 (9.3)	3 (8.6)
Missing	1	1
Race			.37
White	19 (48.7)	16 (48.5)
African American	16 (41.0)	10 (30.3)
Other	4 (10.3)	7 (21.2)
Missing	5	3
Education			.13
≤High school	5 (12.8)	7 (21.2)
Some college	21 (53.8)	10 (30.3)
≥College degree	13 (33.3)	16 (48.5)
Missing	5	3
Marital status			.77
Married	9 (23.1)	10 (30.3)
Single	14 (35.9)	10 (30.3)
Separated/divorced/widowed	16 (41.1)	13 (39.4)
Missing	5	3
Post-menopausal			.28
Yes	6 (15.4)	8 (25.8)
No	33 (84.6)	23 (74.2)
Missing	5	5
Current smoker			.72
Yes	9 (27.3)	8 (23.5)
No	24 (72.7)	26 (76.5)
Missing	11	2
History of yeast vaginitis			.23^*
Yes	37 (94.9)	27 (84.4)
No	2 (5.1)	5 (15.6)
Missing	5	4
Receptive oral sex			.30
Yes	18 (48.6)	12 (36.4)
No	19 (51.4)	21 (63.6)
Missing	7	3
Diabetes mellitus			.66^*
Yes	3 (13.6)	2 (8.3)
No	19 (86.4)	22 (91.7)
Missing	22	12
Birth control pill/patch			.74^*
Yes	6 (16.2)	4 (12.1)
No	31 (83.8)	29 (87.9)
Missing	7	3
Hormone replacement therapy			.12^*
Yes	0 (0)	6 (37.5)
No	7 (100)	10 (62.5)
Missing	37	20

Table 2.

Baseline and Follow-up Candida Culture and Follow-up Symptomatic VVC by Treatment Group

Table 3.

Relative Risk Estimate of Outcomes of Interest in Hypothetical Scenarios of Women Lost to Follow-up

Lost to Follow-up Developed Outcome of Interest, Regardless of Antibiotic Use (%)	Outcomes of Interest
	RR of Positive Candida Culture After Antibiotic Use	RR of Symptomatic VVC After Antibiotic Use
0	2.73	∞^*
5	2.57	11.21
10	2.45	6.30
20	2.28	3.85
30	2.17	3.03
50	2.02	2.37
70	1.93	2.09
100	1.84	1.88