Skip to main content

Main menu

  • HOME
  • ARTICLES
    • Current Issue
    • Ahead of Print
    • Archives
    • Abstracts In Press
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • Other Publications
    • abfm

User menu

Search

  • Advanced search
American Board of Family Medicine
  • Other Publications
    • abfm
American Board of Family Medicine

American Board of Family Medicine

Advanced Search

  • HOME
  • ARTICLES
    • Current Issue
    • Ahead of Print
    • Archives
    • Abstracts In Press
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • JABFM on Bluesky
  • JABFM On Facebook
  • JABFM On Twitter
  • JABFM On YouTube
OtherEthics Feature

The Effect of Conflict of Interest on Biomedical Research and Clinical Practice Guidelines: Can We Trust the Evidence in Evidence-Based Medicine?

John Abramson and Barbara Starfield
The Journal of the American Board of Family Practice September 2005, 18 (5) 414-418; DOI: https://doi.org/10.3122/jabfm.18.5.414
John Abramson
MD, MSFP
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Barbara Starfield
MD, MPH
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. ↵
    Andreoli TE. The undermining of academic medicine. Academe 1999; 6: 32–37. Available from: http://www.aaup.org/publications/Academe/1999/99nd/ND99Andr.htm, accessed 06/14/05.
  2. ↵
    Krimsky S. Science in the private interest. Lanham (MD): Rowman and Littlefield; 2003.
  3. ↵
    Culliton BJ. The academic-industrial complex. Science 1982; 216: 960–2.
    OpenUrlFREE Full Text
  4. ↵
    Bok D. Universities in the marketplace. Princeton (NJ): Princeton University Press; 2003.
  5. ↵
    Dramatic growth of research and development (http://www.phrma.org/publications/publications/profile02/2003%20CHAPTER%202.pdf accessed 6/14/05). In: Pharmaceutical Research and Manufacturers of America, editor. Pharmaceutical Industry Profile 2003. Washington (DC): Pharmaceutical Research and Manufacturers of America; 2003.
  6. ↵
    The House of Commons Health Committee, The Influence of the Pharmaceutical Industry, Volume 1. April 5, 2005, p. 55. Available from: http://www.parliament.the-stationery-office.co.uk/pa/cm200405/cmselect/cmhealth/42/42.pdf, accessed 6/08/05.
  7. ↵
    Petersen M. Madison Ave. has growing role in the business of drug research. New York Times, November 22, 2002.
  8. ↵
    Bodenheimer T. Uneasy alliance–clinical investigators and the pharmaceutical industry. N Engl J Med 2000; 342: 1539–44.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    Als-Nielsen B, Chen W, Gluud C, Kjaergard LL. Association of funding and conclusions in randomized drug trials: a reflection of treatment effect or adverse events? JAMA 2003; 290: 921–8.
    OpenUrlCrossRefPubMedWeb of Science
  10. ↵
    Schulman KA, Seils DM, Timbie JW, et al. A national survey of provisions in clinical-trial agreements between medical schools and industry sponsors. N Engl J Med 2002; 347: 1335–41.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    Effect of user fees on drug approval times, withdrawals, and other agency activities. United States General Accounting Office, September, 2002, p. 9. Available from: http://www.gao.gov/new.items/d02958.pdf, accessed 6/27/05.
  12. ↵
    Willman D. Risk was known as FDA OKd fatal drug. Los Angeles Times. March 11, 2001.
  13. ↵
    American College of Physicians. Guidelines for Counseling Postmenopausal Women About Preventive Hormone Therapy. Ann Intern Med 1992; 117: 1038–41.
  14. ↵
    FDA Arthritis Advisory Committee Briefing Information, February 8, 2001. Available from: http://www.fda.gov/ohrms/dockets/ac/01/briefing/3677b1.htm, accessed 6/27/05.
  15. ↵
    FDA Arthritis Advisory Committee Briefing Information, February 7, 2001. Available from: http://www.fda.gov/ohrms/dockets/ac/01/briefing/3677b1.htm, accessed 6/27/05.
  16. ↵
    Witter J. FDA Advisory Committee Briefing Document, Celebrex capsules, Medical Officer Review, February 7, 2001. Available from: http://www.fda.gov/ohrms/dockets/ac/01/briefing/3677b1_03_med.doc, accessed 6/28/05.
  17. ↵
    Villalba ML. FDA Advisory Committee Briefing Document, Vioxx gastrointestinal safety, February 8, 2001. Available from: http://www.fda.gov/ohrms/dockets/ac/01/briefing/3677b2_03_med.pdf, accessed 9/16/2001.
  18. ↵
    Li Q. FDA Advisory Committee Briefing Document, Statistical Review, February 8, 2001. Available from: http://www.fda.gov/ohrms/dockets/ac/01/briefing/3677b2_04_stats.doc, accessed 6/27/05.
  19. ↵
    FDA Medical Officer’s Gastroenterology Advisory Committee Briefing Document, February 7, 2001. Available from: http://www.fda.gov/ohrms/dockets/ac/01/briefing/3677b1_05_gi.doc, accessed 6/28/05.
  20. ↵
    Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: The CLASS study: a randomized controlled trial. JAMA 2000; 284: 1247–55.
    OpenUrlCrossRefPubMedWeb of Science
  21. ↵
    Okie S. Missing data on Celebrex full study altered picture of drug. Washington Post, August 5, 2001; A11.
  22. ↵
    Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, et al. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. The VIGOR study group. N Engl J Med 2000; 343: 1520–8.
    OpenUrlCrossRefPubMedWeb of Science
  23. ↵
    FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med 2001; 345: 433–42.
    OpenUrlCrossRefPubMedWeb of Science
  24. ↵
    American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000; 43: 1905–15.
    OpenUrlCrossRefPubMedWeb of Science
  25. ↵
    National Guideline Clearinghouse. Available from: http://www.guidelines.gov/
  26. ↵
    Choudhry NK, Stelfox HT, Detsky AS. Relationships between authors of clinical practice guidelines and the pharmaceutical industry. JAMA 2002; 287: 612–7.
    OpenUrlCrossRefPubMedWeb of Science
  27. ↵
    Grundy SM, Cleeman JI, Merz CN, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004; 110: 227–39.
    OpenUrlAbstract/FREE Full Text
  28. ↵
    National Cholesterol Education Program. Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Available from: http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3upd04_disclose.htm accessed 6/14/05. Bethesda (MD): National Heart, Lung, and Blood Institute, 2004.
  29. ↵
    Willman D. The National Institutes of Health: public servant or private marketer? Los Angeles Times, December 22, 2004;1.
  30. ↵
    American Heart Association. American Heart Association Annual Report 2004: Learn and Live. Available from: http://www.americanheart.org/downloadable/heart/1106163695297FINAL%20Annual04%20ASA%20Update.pdf, accessed 6/14/05. Dallas (TX): American Heart Association, 2004.
  31. ↵
    Arthritis Foundation, Arthritis Foundation Annual Report 2002: Think it’s just arthritis? The truth hurts. Available from: http://www.arthritis.org/resources/aboutus/Annual_Reports/2002/Annual%20Report.Final.pdf, accessed 6–14-05). Atlanta (GA): Arthritis Foundation, 2002.
  32. ↵
    American Diabetes Association. American Diabetes Association Report 2004: rising to meet the challenge. Available from: http://www.diabetes.org/uedocuments/AnnualFINAL.pdf, accessed 6–14-05. Alexandria (VA): American Diabetes Association, 2005.
  33. ↵
    Relman AS. Industry sponsorship of continuing medical education—reply. JAMA 2003; 290: 1150.
    OpenUrlCrossRefPubMed
  34. ↵
    2005 Match Information Sheet, American Academy of Family Practice. Available from: http://www.aafp.org/match/graph05.html, accessed 6/27/05.
  35. ↵
    Kravitz RL, Duan N, Braslow J. Evidence-based medicine, heterogeneity of treatment effects, and the trouble with averages. Milbank Q 2004; 82: 661–87.
    OpenUrlCrossRefPubMedWeb of Science
  36. Rothwell PM. External validity of randomised controlled trials: to whom do the results of this trial apply? Lancet 2005; 365: 82–93.
    OpenUrlCrossRefPubMedWeb of Science
  37. Steinberg EP, Luce BR. Evidence based? Caveat emptor! Health Aff 2005; 24: 80–92.
    OpenUrlAbstract/FREE Full Text
PreviousNext
Back to top

In this issue

The Journal of the American Board of Family Practice: 18 (5)
The Journal of the American Board of Family Practice
Vol. 18, Issue 5
1 Sep 2005
  • Table of Contents
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Board of Family Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Effect of Conflict of Interest on Biomedical Research and Clinical Practice Guidelines: Can We Trust the Evidence in Evidence-Based Medicine?
(Your Name) has sent you a message from American Board of Family Medicine
(Your Name) thought you would like to see the American Board of Family Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
16 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
The Effect of Conflict of Interest on Biomedical Research and Clinical Practice Guidelines: Can We Trust the Evidence in Evidence-Based Medicine?
John Abramson, Barbara Starfield
The Journal of the American Board of Family Practice Sep 2005, 18 (5) 414-418; DOI: 10.3122/jabfm.18.5.414

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
The Effect of Conflict of Interest on Biomedical Research and Clinical Practice Guidelines: Can We Trust the Evidence in Evidence-Based Medicine?
John Abramson, Barbara Starfield
The Journal of the American Board of Family Practice Sep 2005, 18 (5) 414-418; DOI: 10.3122/jabfm.18.5.414
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Notes
    • References
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Statin wars: have we been misled about the evidence? A narrative review
  • Developing a Clinician Friendly Tool to Identify Useful Clinical Practice Guidelines: G-TRUST
  • Higher Integrity Health Care: Evidence-Based Shared Decision Making
  • Introduction of More Editorial Board Members and the Most Frequently Read Articles in 2008
  • Assessing and scaling the knowledge pyramid: the good-guideline guide
  • Conflict of Interest: Can We Minimize Its Influence in the Biomedical Literature?
  • Google Scholar

More in this TOC Section

  • Becoming a Phronimos: Evidence-Based Medicine, Clinical Decision Making, and the Role of Practical Wisdom in Primary Care
  • A General Framework for Exploring Ethical and Legal Issues in Sports Medicine
  • An Ethical Framework to Manage Patient Requests for Medical Marijuana
Show more Ethics Feature

Similar Articles

Navigate

  • Home
  • Current Issue
  • Past Issues

Authors & Reviewers

  • Info For Authors
  • Info For Reviewers
  • Submit A Manuscript/Review

Other Services

  • Get Email Alerts
  • Classifieds
  • Reprints and Permissions

Other Resources

  • Forms
  • Contact Us
  • ABFM News

© 2025 American Board of Family Medicine

Powered by HighWire