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Brief ReportBrief Report

Paget-Schroetter Syndrome in the Young and Active

Viju Vijaysadan, Aphrodite M. Zimmerman and Rafael E. Pajaro
The Journal of the American Board of Family Practice July 2005, 18 (4) 314-319; DOI: https://doi.org/10.3122/jabfm.18.4.314
Viju Vijaysadan
MD
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Aphrodite M. Zimmerman
MS
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Rafael E. Pajaro
MD
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  • Figure 1.
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    Figure 1.

    Venogram showing initial thrombus in the right brachial, axillary, and subclavian veins (upper left) and different stages of thrombolysis to successful lysis of thrombus (lower right).

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    Table 1.

    Signs and Symptoms of Axillary-Subclavianvein Thrombosis versus Thoracic Outlet Syndrome

    ConditionSymptomsSigns
    Axillary-subclavian thrombosisVague shoulder or neck discomfort; arm, hand edemaSupraclavicular fullness, palpable cord, extremity edema/cyanosis, jugular vein distention, dilated veins, unable to access catheter
    Thoracic outlet syndromePain radiating to arm; hand weaknessBrachial plexus tenderness, arm/hand atrophy, positive Adson or Wright test
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    Table 2.

    Imaging Modes Used and Their Risk and Benefits

    Diagnostic TestAdvantageDisadvantage
    Duplex UltrasoundInexpensive, reproducible, noninvasiveFailure to detect thrombus under clavicle in subclavian vein
    CTVessel compression from outside; may define central thrombusContrast required; not validated in entirety
    MRIDetects central thrombus with accuracy; good evaluation of collateralsUnsuitable for patients with metal implant or pacemaker; claustrophobia
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    Table 3.

    Provocative Physical Tests

    Diagnostic TestManeuverPositive TestMechanism
    Adson (scalene)The patient is instructed to inspire maximally and hold his or her breath while the neck is fully extended and the head is turned toward the affected side.The loss or decrease of radial pulse or the reproduction of neurologic symptoms suggests a positive test.The Adson (scalene) test causes narrowing of the space between the scalenus anticus and medius, resulting in compression of the subclavian artery and the brachial plexus.
    Halsted (costoclavicular)The patient is instructed to place his or her shoulders in a military position (drawn backward and downward).The loss or decrease of radial pulse or the reproduction of neurologic symptoms suggests a positive test.The Halsted (costoclavicular) test is used to narrow the costoclavicular space between the first rib and the clavicle, thereby causing neurovascular compression
    Wright (hyperabduction)To perform the test, the patient’s arm is hyperabducted 180°.The loss or decrease of radial pulse or the reproduction of neurologic symptoms suggests a positive test.The Wright (hyperabduction) test causes the neurovascular structures to be compressed in the subcoracoid region by the pectoralis tendon, the head of the humerus, or the coracoid process and muscles/tendons arising from the process.

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  • Video Excerpts: Paget-Schroetter Syndrome in the Young and Active

    1. Inspection: Muscular body habitus, homogenous, no-pitting edema, and diffuse erythema that blanched to palpation are prominent features on inspection. 2. History: Patient reveals swelling, redness, and limitation of function. Opening up of collateral circulation after development of thrombus. 3. History: Patient reveals neurovascular symptoms accentuated on abduction due to extrinsic mechanical compression at sub-coracoid level. A provocative test, Wright�s, is positive. 4. Wrights� Test: attenuation of radial pulse on abduction beyond 180 degrees; here there is disappearance of radial pulse beyond 180 consistent with mechanical obstruction at sub- coracoid level due to hypertrophied muscles. Patient reveals symptoms and signs of thrombosis as palpable cord, in addition to other non-specific features that might be seen in various other diagnoses.

    Files in this Data Supplement:

    • 1. Inspection - Muscular body habitus, homogenous, no-pitting edema, and diffuse erythema that blanched to palpation are prominent features on inspection.
    • 2. History - Patient reveals swelling, redness, and limitation of function. Opening up of collateral circulation after development of thrombus.
    • 3. History - Patient reveals neurovascular symptoms accentuated on abduction due to extrinsic mechanical compression at sub-coracoid level. A provocative test, Wright�s, is positive.
    • 4. Wright's Test - Wrights� test shows attenuation of radial pulse on abduction beyond 180 degrees; here there is disappearance of radial pulse beyond 180 consistent with mechanical obstruction at sub-coracoid level due to hypertrophied muscles. Patient reveals symptoms and signs of thrombosis as palpable cord, in addition to other non-specific features that might be seen in various other diagnoses.
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The Journal of the American Board of Family Practice: 18 (4)
The Journal of the American Board of Family Practice
Vol. 18, Issue 4
July-August 2005
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Paget-Schroetter Syndrome in the Young and Active
Viju Vijaysadan, Aphrodite M. Zimmerman, Rafael E. Pajaro
The Journal of the American Board of Family Practice Jul 2005, 18 (4) 314-319; DOI: 10.3122/jabfm.18.4.314

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Paget-Schroetter Syndrome in the Young and Active
Viju Vijaysadan, Aphrodite M. Zimmerman, Rafael E. Pajaro
The Journal of the American Board of Family Practice Jul 2005, 18 (4) 314-319; DOI: 10.3122/jabfm.18.4.314
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