OtherEvidence-Based Clinical Medicine
Is Your Depressed Patient Bipolar?
Neil S. Kaye
The Journal of the American Board of Family
Practice July 2005, 18 (4) 271-281; DOI: https://doi.org/10.3122/jabfm.18.4.271

References
- ↵
- ↵Ballenger JC, Davidson JR, Lecrubier Y, et al. Consensus statement on the primary care management of depression from the International Consensus Group on Depression and Anxiety. J Clin Psychiatry 1999; 60 Suppl 7: 54–61.
- ↵Angst J, Sellaro R. Historical perspectives and natural history of bipolar disorder. Biol Psychiatry 2000; 48: 445–57.
- ↵Compton MT, Nemeroff CB. The treatment of bipolar depression. J Clin Psychiatry 2000; 61: 57–67.
- ↵Thase ME, Sachs GS. Bipolar depression: pharmacotherapy and related therapeutic strategies. Biol Psychiatry 2000; 48: 558–72.
- ↵Sachs GS, Printz DJ, Kahn DA, Carpenter D, Docherty JP. The expert consensus guideline series: medication treatment of bipolar disorder 2000. Postgrad Med 2000;Spec No: 1–104
- ↵American Psychiatric Association. Practice guideline for the treatment of patients with bipolar disorder (revision). Am J Psychiatry 2002; 159: 1–50.
- ↵American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th ed. Washington DC: American Psychiatric Publishing, Inc; 1994.
- ↵American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th ed, text rev. Washington DC: American Psychiatric Publishing, Inc; 2000.
- ↵Regier DA, Farmer ME, Rae DS, et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 1990; 264: 2511–8.
- ↵Angst J. The emerging epidemiology of hypomania and bipolar II disorder. J Affect Disord 1998; 50: 143–51.
- ↵Angst J, Gamma A, Benazzi F, Ajdacic V, Eich D, Rossler W. Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. J Affect Disord 2003; 73: 133–46.
- Akiskal HS, Bourgeois ML, Angst J, Post R, Moller H, Hirschfeld R. Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J Affect Disord 2000; 59 Suppl 1: S5–30.
- ↵
- ↵Benazzi F. Frequency of bipolar spectrum in 111 private practice depression outpatients. Eur Arch Psychiatry Clin Neurosci 2003; 253: 203–8.
- Judd LL, Akiskal HS. The prevalence and disability of bipolar spectrum disorders in the US population: re-analysis of the ECA database taking into account subthreshold cases. J Affect Disord 2003; 73: 123–31.
- Akiskal HS, Pinto O. The evolving bipolar spectrum. Prototypes I, II, III, and IV. Psychiatr Clin North Am 1999; 22: 517–34, vii.
- ↵Goodwin FK, Jamison KR. Suicide. Manic-depressive illness. New York: Oxford University Press, Inc; 1990. p. 227–46.
- ↵Hirschfeld RM, Lewis L, Vornik LA. Perceptions and impact of bipolar disorder: how far have we really come? Results of the National Depressive and Manic-Depressive Association 2000 survey of individuals with bipolar disorder. J Clin Psychiatry 2003; 64: 161–74.
- ↵Manning JS, Haykal RF, Akiskal HS. The role of bipolarity in depression in the family practice setting. Psychiatr Clin North Am 1999; 22: 689–703, x.
- ↵Manning JS. Bipolar disorder in primary care. J Fam Pract 2003; Suppl: S6–9.
- ↵Bowden CL. Strategies to reduce misdiagnosis of bipolar depression. Psychiatr Serv 2001; 52: 51–5.
- ↵Pini S, Cassano GB, Dell’Osso L, Amador XF. Insight into illness in schizophrenia, schizoaffective disorder, and mood disorders with psychotic features. Am J Psychiatry 2001; 158: 122–5.
- ↵Yen CF, Chen CS, Yeh ML, Ker JH, Yang SJ, Yen JY. Correlates of insight among patients with bipolar I disorder in remission. J Affect Disord 2004; 78: 57–60.
- ↵
- ↵Ghaemi SN, Sachs GS, Chiou AM, Pandurangi AK, Goodwin K. Is bipolar disorder still underdiagnosed? Are antidepressants overutilized? J Affect Disord 1999; 52: 135–44.
- ↵Ghaemi SN, Boiman EE, Goodwin FK. Diagnosing bipolar disorder and the effect of antidepressants: a naturalistic study. J Clin Psychiatry 2000; 61: 804–8.
- ↵Hirschfeld RM. Bipolar spectrum disorder: improving its recognition and diagnosis. J Clin Psychiatry 2001; 62 Suppl 14: 5–9.
- ↵
- ↵Lish JD, Dime-Meenan S, Whybrow PC, Price RA, Hirschfeld RM. The National Depressive and Manic-Depressive Association (DMDA) survey of bipolar members. J Affect Disord 1994; 31: 281–94.
- ↵Jamison KR. Suicide and bipolar disorder. J Clin Psychiatry 2000; 61: 47–51.
- ↵Wehr TA, Goodwin FK. Can antidepressants cause mania and worsen the course of affective illness? Am J Psychiatry 1987; 144: 1403–11.
- ↵Altshuler LL, Post RM, Leverich GS, Mikalauskas K, Rosoff A, Ackerman L. Antidepressant-induced mania and cycle acceleration: A controversy revisited. Am J Psychiatry 1995; 152: 1130–8.
- ↵
- Dunner DL, Tay LK. Diagnostic reliability of the history of hypomania in bipolar II patients and patients with major depression. Compr Psychiatry 1993; 34: 303–7.
- Cassano GB, Dell’Osso L, Frank E, et al. The bipolar spectrum: a clinical reality in search of diagnostic criteria and an assessment methodology. J Affect Disord 1999; 54: 319–28.
- ↵Judd LL, Akiskal HS, Schettler PJ, et al. A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Arch Gen Psychiatry 2003; 60: 261–9.
- ↵Hirschfeld RM, Williams JB, Spitzer RL, et al. Development and validation of a screening instrument for bipolar spectrum disorder: The Mood Disorder Questionnaire. Am J Psychiatry 2000; 157: 1873–5.
- ↵
- ↵Abrams R, Taylor MA. A comparison of unipolar and bipolar depressive illness. Am J Psychiatry 1980; 137: 1084–7.
- Geller B, Craney JL, Bolhofner K, DelBello MP, Williams M, Zimerman B. One-year recovery and relapse rates of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 2001; 158: 303–5.
- ↵Akiskal HS, Maser JD, Zeller PJ, et al. Switching from ‘unipolar’ to bipolar II. An 11-year prospective study of clinical and temperamental predictors in 559 patients. Arch Gen Psychiatry 1995; 52: 114–23.
- ↵Goldberg JF, Harrow M, Whiteside JE. Risk for bipolar illness in patients initially hospitalized for unipolar depression. Am J Psychiatry 2001; 158: 1265–70.
- ↵Goldberg AL, Elledge SJ, Harper JW. The cellular chamber of doom. Sci Am 2001; 284: 68–73.
- ↵Manning JS, Haykal RF, Connor PD, Akiskal HS. On the nature of depressive and anxious states in a family practice setting: the high prevalence of bipolar II and related disorders in a cohort followed longitudinally. Compr Psychiatry 1997; 38: 102–8.
- Goodwin FK, Jamison KR. Medical treatment of acute bipolar depression. In: Manic-depressive illness. Oxford (UK): Oxford University Press, Inc.; 1990. p. 630–64.
- ↵Coryell W. Bipolar II disorder: the importance of hypomania. In: Goldberg JF and Harrow M, editors. Bipolar disorders: clinical course and outcome. Washington DC: American Psychiatric Publishing; 1999. p. 219–36.
- ↵Weissman MM, Wickramaratne P, Adams P, Wolk S, Verdeli H, Olfson M. Brief screening for family psychiatric history: the family history screen. Arch Gen Psychiatry 2000; 57: 675–82.
- ↵Ghaemi SN, Ko JY, Goodwin FK. The bipolar spectrum and the antidepressant view of the world. J Psychiatr Pract 2001; 7: 287.
- ↵
- ↵Whybrow PC. A mood apart: depression, mania, and other afflictions of the self. New York: HarperCollins; 1997.
- ↵Robling SA, Paykel ES, Dunn VJ, Abbott R, Katona C. Long-term outcome of severe puerperal psychiatric illness: a 23 year follow-up study. Psychol Med 2000; 30: 1263–71.
- ↵Potter WZ. Bipolar depression: specific treatments. J Clin Psychiatry 1998; 59 Suppl 18: 30–6.
- ↵Kupfer DJ, Frank E, Grochocinski VJ, Cluss PA, Houck PR, Stapf DA. Demographic and clinical characteristics of individuals in a bipolar disorder case registry. J Clin Psychiatry 2002; 63: 120–5.
- ↵Tohen M, Vieta E, Calabrese J, et al. Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression. Arch Gen Psychiatry 2003; 60: 1079–88.
- ↵Physicians’ Desk Reference. 59th ed. Montvale (NJ): Medical Economics Company, Inc; 2005. Eskalith; p. 1486.
- ↵
- Goodwin FK, Fireman B, Simon GE, Hunkeler EM, Lee J, Revicki D. Suicide risk in bipolar disorder during treatment with lithium and divalproex. JAMA 2003; 290: 1467–73.
- ↵Kleindienst N, Greil W. Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: results of the MAP study. Neuropsychobiology 2000; 42: 2–10.
- ↵Physicians’ Desk Reference, 57th ed. Montvale (NJ): Thomson PDR; 2003. Depakote; p. 430–41.
- ↵Physicians’ Desk Reference. 59th ed. Montvale (NJ): Medical Economics Company, Inc; 2005. Tegretol; p. 436–41.
- ↵Calabrese JR, Bowden CL, Sachs GS, Ascher JA, Monaghan E, Rudd GD. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. Lamictal 602 Study Group. J Clin Psychiatry 1999; 60: 79–88.
- ↵Bowden CL, Calabrese JR, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry 2003; 60: 392–400.
- ↵Calabrese JR, Bowden CL, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry 2003; 64: 1013–24.
- ↵Physicians’ desk reference, 57th ed. Montvale (NJ): Thomson PDR; 2003. Lamictal; p. 1559–66.
- ↵Allison DB, Casey DE. Antipsychotic-induced weight gain: a review of the literature. J Clin Psychiatry 2001; 62 Suppl 7: 22–31.
- ↵Schwenkreis P, Assion HJ. Atypical antipsychotics and diabetes mellitus. World J Biol Psychiatry 2004; 5: 73–82.
- ↵American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity. Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care 2004; 27: 596–601.
- ↵Ghaemi SN, Ko JY, Goodwin FK. “Cade’s disease” and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder. Can J Psychiatry 2002; 47: 125–34.
In this issue
The Journal of the American Board of Family
Practice
Vol. 18, Issue 4
July-August 2005
Is Your Depressed Patient Bipolar?
Neil S. Kaye
The Journal of the American Board of Family
Practice Jul 2005, 18 (4) 271-281; DOI: 10.3122/jabfm.18.4.271
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