Research ArticleOriginal Article

The Effectiveness of Various Postpartum Depression Treatments and the Impact of Antidepressant Drugs on Nursing Infants

Dwenda Gjerdingen
The Journal of the American Board of Family Practice September 2003, 16 (5) 372-382; DOI: https://doi.org/10.3122/jabfm.16.5.372

REFERENCES

  1. ↵
    O’Hara MW, Swain AM. Rates and risk of postpartum depression—a meta-analysis. Int Rev Psychiatry 1996; 8: 37–54.
  2. ↵
    Gjerdingen DK, Chaloner KM. The relationship of women’s postpartum mental health to employment, childbirth, and social support. J Fam Pract 1994; 38: 465–72.
    OpenUrlPubMedWeb of Science
  3. ↵
    Steiner M. Perinatal mood disorders: position paper. Psychopharmacol Bull 1998; 34: 301–6.
    OpenUrlPubMedWeb of Science
  4. ↵
    Anonymous. Practice guideline for major depressive disorder in adults. American Psychiatric Association. Am J Psychiatry 1993; 150 (4 Suppl): 1–26.
    OpenUrlPubMedWeb of Science
  5. ↵
    Murray L, Fiori-Cowley A, Hooper R, Cooper P. The impact of postnatal depression and associated adversity on early mother-infant interactions and later infant outcome. Child Dev 1996; 67: 2512–26.
    OpenUrlCrossRefPubMedWeb of Science
  6. ↵
    Beck CT. The effects of postpartum depression on child development: a meta-analysis. Arch Psychiatr Nurs 1998; 12: 12–20.
    OpenUrlCrossRefPubMedWeb of Science
  7. ↵
    Politano PM, Stapleton LA, Correll JA. Differences between children of depressed and non-depressed mothers: locus of control, anxiety and self-esteem: a research note. J Child Psychol Psychiatr 1992; 33: 451–5.
    OpenUrlPubMed
  8. ↵
    Anonymous. Screening for depression: recommendations and rationale. Am Fam Physician 2002; 66: 647–50.
    OpenUrlPubMedWeb of Science
  9. ↵
    Georgiopoulos AM, Bryan TL, Wollan P, Yawn BP. Routine screening for postpartum depression. J Fam Pract 2001; 50: 117–2.
    OpenUrlPubMedWeb of Science
  10. ↵
    Whooley MA, Avins AL, Miranda J, Browner WS. Case-finding instruments for depression: two questions are as good as many. J Gen Intern Med 1997; 12: 439–45.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    Culpepper L. The active management of depression. J Fam Pract 2002; 51: 769–76.
    OpenUrlPubMed
  12. ↵
    Winans EA. Antidepressant use during lactation. J Hum Lact 2001; 17: 256–61.
    OpenUrlAbstract/FREE Full Text
  13. ↵
    Wisner KL, Perel JM, Findling RL. Antidepressant treatment during breast-feeding. Am J Psychiatry 1996; 153: 1132–37.
    OpenUrlPubMedWeb of Science
  14. ↵
    Wisner KL, Parry BL, Piontek CM. Postpartum depression. N Engl J Med 2002; 347: 194–9.
    OpenUrlCrossRefPubMedWeb of Science
  15. ↵
    Mulrow CD, Williams JW, Trivedi M, Chiquette E, Aguilar C, et al. Evidence report on treatment of depression—newer pharmacotherapies. Psychopharmacol Bull 1998; 34: 409–47.
    OpenUrlPubMed
  16. ↵
    Ables AZ, Baughman OL. Antidepressants: update on new agents and indications. Am Fam Physician 2003; 67: 547–54.
    OpenUrlPubMedWeb of Science
  17. ↵
    Majeroni BA, Hess A. The pharmacologic treatment of depression. J Am Board Fam Pract 1998; 11: 127–39.
    OpenUrlAbstract/FREE Full Text
  18. ↵
    Stowe ZN, Casarella J, Landry J, Nemeroff CB. Sertraline in the treatment of women with postpartum major depression. Depression 1995; 3: 49–55.
  19. ↵
    Suri R, Burt VK, Altshuler LL, Zuckerbrow-Miller J, Fairbanks L. Fluvoxamine for postpartum depression. Am J Psychiatry 2001; 158: 1739–40.
    OpenUrlCrossRefPubMedWeb of Science
  20. ↵
    Cohen LS, Viguera AC, Bouffard SM, et al. Venlafaxine in the treatment of postpartum depression. J Clin Psychiatry 2001; 62: 592–6.
    OpenUrlPubMedWeb of Science
  21. ↵
    Appleby L, Warner R, Whitton A, Faragher B. A controlled study of fluoxetine and cognitive-behavioural counselling in the treatment of postnatal depression. BMJ 1997; 314: 932–6.
    OpenUrlAbstract/FREE Full Text
  22. ↵
    Yoshida K, Kumar R. Breast feeding and psychotropic drugs. Int Rev Psychiatry 1996; 8: 117–24.
  23. Jensen PN, Olesen OV, Bertelsen A, Linnet K. Citalopram and desmethylcitalopram concentrations in breast milk and in serum of mother and infant. Ther Drug Monit 1997; 19: 236–9.
    OpenUrlCrossRefPubMed
  24. ↵
    Schmidt K, Olesen OV, Jensen PN. Citalopram and breast-feeding: serum concentration and side effects in the infant. Biol Psychiatry 2000; 47: 164–5.
    OpenUrlCrossRefPubMedWeb of Science
  25. Rampono J, Kristensen JH, Hackett LP, Paech M, Kohan R, Ilett KF. Citalopram and demethylcitalopram in human milk; distribution, excretion and effects in breast fed infants. Br J Clin Pharmacol 2000; 50: 263–8.
    OpenUrlCrossRefPubMedWeb of Science
  26. Spigset O, Careborg L, Ohman R, Norstrom A. Excretion of citalopram in breast milk. Br J Clin Pharmacol 1997; 44: 295–8.
    OpenUrlCrossRefPubMedWeb of Science
  27. ↵
    Brent NB, Wisner KL. Fluoxetine and carbamazepine concentrations in a nursing mother/infant pair. Clin Pediatr (Phila) 1998; 37: 41–4.
    OpenUrlFREE Full Text
  28. Burch KJ, Wells BG. Fluoxetine/norfluoxetine concentration in human milk. Pediatrics 1992; 86: 676–7.
    OpenUrl
  29. ↵
    Chambers CD, Anderson PO, Thomas RG, et al. Weight gain in infants breastfed by mothers who take fluoxetine. Pediatrics 1999; 104(5): e61.
  30. Hendrick V, Stowe ZN, Altshuler LL, et al. Fluoxetine and norfluoxetine concentrations in nursing infants and breast milk. Biol Psychiatry 2001; 50: 775–82.
    OpenUrlCrossRefPubMedWeb of Science
  31. ↵
    Isenberg KE. Excretion of fluoxetine in human breast milk [letter]. J Clin Psychiatry 1990; 51: 169.
    OpenUrlPubMedWeb of Science
  32. ↵
    Kristensen JH, Ilett KF, Hackett LP, Yapp P, Paech M, Begg EJ. Distribution and excretion of fluoxetine and norfluoxetine in human milk. Br J Clin Pharmacol 1999; 48: 521–7.
    OpenUrlCrossRefPubMedWeb of Science
  33. ↵
    Lester BM, Cucca J, Andreozzi L, Flanagan P, Oh W. Possible association between fluoxetine hydrochloride and colic in an infant. J Am Acad Child Adolesc Psychiatry 1993; 32: 1253–55.
    OpenUrlPubMedWeb of Science
  34. Taddio A, Ito S, Koren G. Excretion of fluoxetine and its metabolite, norfluoxetine, in human breast milk. J Clin Pharmacol 1996; 36: 42–7.
    OpenUrlPubMedWeb of Science
  35. Yoshida K, Smith B, Craggs M, Kumar RC. Fluoxetine in breast-milk and developmental outcome of breast-fed infants. Br J Psychiatry 1998; 172: 175–8.
    OpenUrlAbstract/FREE Full Text
  36. Hendrick V, Fukuchi A, Altshuler L, Widawski M, Wertheimer A, Brunhuber MV. Use of sertraline, paroxetine and fluvoxamine by nursing women. Br J Psychiatry 2001; 179: 163–6.
    OpenUrlAbstract/FREE Full Text
  37. ↵
    Piontek CM, Wisner KL, Perel JM, Peindl KS. Serum fluvoxamine levels in breastfed infants. J Clin Psychiatry 2001; 62: 111–3.
    OpenUrlPubMedWeb of Science
  38. Wright S, Dawling S, Ashford JJ. Excretion of fluvoxamine in breast milk [letter]. Br J Clin Pharmacol 1991; 31: 209.
    OpenUrlPubMedWeb of Science
  39. Yoshida K, Smith B, Kumar RC. Fluvoxamine in breast-milk and infant development. Br J Clin Pharmacol 1997; 44: 210–1.
    OpenUrlPubMedWeb of Science
  40. Misri S, Kim J, Riggs KW, Kostaras X. Paroxetine levels in postpartum depressed women, breast milk, and infant serum. J Clin Psychiatry 2000; 61: 828–32.
    OpenUrlPubMedWeb of Science
  41. Ohman R, Hagg S, Carleborg L, Spigset O. Excretion of paroxetine into breast milk. J Clin Psychiatry 1999; 60: 519–23.
    OpenUrlPubMedWeb of Science
  42. Stowe ZN, Cohen LS, Hostetter A, Ritchie JC, Owens MJ, Nemeroff CB. Paroxetine in human breast milk and nursing infants. Am J Psychiatry 2000; 157: 185–9.
    OpenUrlCrossRefPubMedWeb of Science
  43. Altshuler LL, Burt VK, McMullen M, Hendrick V. Breastfeeding and sertraline: a 24-hour analysis. J Clin Psychiatry 1995; 56: 243–5.
    OpenUrlPubMedWeb of Science
  44. Dodd S, Stocky A, Buist A, Burrows GD, Norman TR. Sertraline analysis in the plasma of breast-fed infants. Aust N Z J Psychiatry 2001; 35: 545–6.
    OpenUrlFREE Full Text
  45. Epperson N, Czarkowski KA, Ward-O’Brien D, et al. Maternal sertraline treatment and serotonin transport in breast-feeding mother-infant pairs. Am J Psychiatry 2001; 158: 1631–7.
    OpenUrlCrossRefPubMedWeb of Science
  46. Holland D. An observation of the effect of sertraline on breast milk supply [letter]. Aust N Z J Psychiatry 2000; 34: 1032.
    OpenUrl
  47. ↵
    Stowe ZN, Owens MJ, Landry JC, et al. Sertraline and desmethylsertraline in human breast milk and nursing infants. Am J Psychiatry 1997; 154: 1255–60.
    OpenUrlPubMedWeb of Science
  48. Wisner KL, Perel JM, Blumer J. Serum sertraline and N-desmethylsertraline levels in breast-feeding mother-infant pairs. Am J Psychiatry 1998; 155: 690–2.
    OpenUrlPubMedWeb of Science
  49. Bader TF, Newman K. Amitriptyline in human breast milk and the nursing infant’s serum. Am J Psychiatry 1980; 137: 855–6.
    OpenUrlPubMedWeb of Science
  50. Breyer-Pfaff U, Nill K, Entenmann KN, Gaertner HJ. Secretion of amitriptyline and metabolites into breast milk. Am J Psychiatry 1995; 152: 812–3.
  51. Brixen-Rasmussen L, Halgrener J, Jorgensen A. Amitriptyline and nortriptyline excretion in human breast milk. Psychopharmacology 1982; 76: 94–5.
    OpenUrlCrossRefPubMed
  52. Erickson SH, Smith GH, Heidrich F. Tricyclics and breast feeding [letter]. Am J Psychiatry 1979; 136: 1483–4.
    OpenUrlPubMedWeb of Science
  53. Pittard WB, O’Neal W. Amitriptyline excretion in human milk. J Clin Psychopharmacol 1986; 6: 383–4.
    OpenUrlCrossRefPubMedWeb of Science
  54. Yoshida K, Smith B, Craggs M, Kumar C. Investigation of pharmacokinetics and of possible adverse effects in infants exposed to tricyclic antidepressants in breast-milk. J Affect Disord 1997; 43: 225–37.
    OpenUrlCrossRefPubMedWeb of Science
  55. Schimmell MS, Katz EZ, Shaag Y, Pastuszak A, Koren G. Toxic neonatal effects following maternal clomipramine therapy. J Toxicol Clin Toxicol 1991; 29: 479–84.
    OpenUrlCrossRefPubMedWeb of Science
  56. Wisner KL, Perel JM, Foglia JP. Serum clomipramine and metabolite levels in four nursing mother-infant pairs. J Clin Psychiatry 1995; 56: 17–20.
    OpenUrlPubMedWeb of Science
  57. Stancer HC, Reed KL. Desipramine and 2-hydroxydesipramine in human breast milk and the nursing infant’s serum. Am J Psychiatry 1986; 143: 1597–600.
    OpenUrlPubMedWeb of Science
  58. ↵
    Frey OR, Scheidt P, von Brenndorff A. Adverse effects in a newborn infant breast-fed by a mother treated with doxepin. Ann Pharmacother 1999; 33: 690–3.
    OpenUrlAbstract/FREE Full Text
  59. Kemp J, Ilett KF, Booth J, Hackett LP. Excretion of doxepin and N-desmethyldoxepin in human milk. Br J Clin Pharmacol 1985; 20: 497–9.
    OpenUrlPubMedWeb of Science
  60. ↵
    Matheson I, Pande H, Alertsen AR. Respiratory depression caused by N-desmethyldoxepin in breast milk [letter]. Lancet 1985; 2: 1124.
    OpenUrlPubMedWeb of Science
  61. Sovner R, Orsulak PJ. Excretion of imipramine and desipramine in human breast milk. Am J Psychiatry 1979; 136: 451–2.
  62. Mammen O, Perel JM, Wheeler S. Antidepressants and breast-feeding. Am J Psychiatry 1997; 54: 1174–5.
    OpenUrl
  63. Matheson I, Skjaeraasen J. Milk concentrations of flupenthixol, nortriptyline, and zuclophenthixol and between-breast differences in two patients. Eur J Clin Pharmacol 1988; 35: 217–20.
    OpenUrlCrossRefPubMedWeb of Science
  64. Wisner KL, Perel JM. Serum nortriptyline levels in nursing mothers and their infants. Am J Psychiatry 1991; 148: 1234–6.
    OpenUrlPubMedWeb of Science
  65. Wisner KL, Perel JM. Nortriptyline treatment of breast-feeding women [letter]. Am J Psychiatry 1996; 153: 295.
  66. Wisner KL, Perel JM, Findling RL, Hinnes RL. Nortriptyline and its hydroxymetabolites in breastfeeding mothers and newborns. Psychopharmacol Bull 1997; 33: 249–51.
    OpenUrlPubMed
  67. Briggs GG, Samson JH, Ambrose PJ, Schroeder DH. Excretion of bupropion in breast milk. Ann Pharmacother 1993; 27: 431–3.
    OpenUrlPubMedWeb of Science
  68. ↵
    Yapp P, Ilett KF, Kristensen JH, Hackett LP, Paech MJ, Rampono J. Drowsiness and poor feeding in a breast-fed infant: association with nefazodone and its metabolites. Ann Pharmacother 2000; 34: 1269–72.
    OpenUrlAbstract/FREE Full Text
  69. Ilett KF, Hackett LP, Dusci LJ, et al. Distribution and excretion of venlafaxine and O-desmethylvenlafaxine in human milk. Br J Clin Pharmacol 1998; 45: 459–62.
    OpenUrlCrossRefPubMedWeb of Science
  70. Ilett KF, Kristensen JH, Hackett LP, Paech M, Kohan R, Rampono J. Distribution of venlafaxine and its O-desmethyl metabolite in human milk and their effects in breastfed infants. Br J Clin Pharmacol 2002; 53: 17–22.
    OpenUrlCrossRefPubMedWeb of Science
  71. ↵
    Hoffbrand S, Howard L, Crawley H. Antidepressant drug treatment for postnatal depression. Cochrane Database Syst Rev 2001; (2): CD002018.
    OpenUrl
  72. ↵
    Cizza G, Gold PW, Chrousos GP. High-dose transdermal estrogen, corticotropin-releasing hormone, and postnatal depression [letter]. J Clin Endocrinol Metab 1997; 82: 704.
  73. ↵
    Ahokas A, Kaukoranta J, Wahlbeck K, Aito M. Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17β-estradiol: a preliminary study. J Clin Psychiatry 2001; 62: 332–6.
    OpenUrlCrossRefPubMedWeb of Science
  74. ↵
    Ahokas AJ, Turtiainen S, Aito M. Sublingual oestrogen treatment of postnatal depression [letter]. Lancet 1998; 351: 109.
    OpenUrlPubMedWeb of Science
  75. ↵
    Gregoire AJ, Kumar R, Everitt B, Henderson AF, Studd JW. Transdermal oestrogen for treatment of severe postnatal depression. Lancet 1996; 347: 930–3.
    OpenUrlCrossRefPubMedWeb of Science
  76. ↵
    Ahokas A, Aito M. Role of estradiol in puerperal psychosis. Psychopharmacology (Berl) 1999; 147: 108–10.
    OpenUrlPubMed
  77. ↵
    Ahokas A, Aito M, Turiainen S. Association between oestradiol and puerperal psychosis. Acta Psychiatr Scand 2000; 101: 167–70.
    OpenUrlPubMed
  78. ↵
    Granger ACP, Underwood MR. Review of the role of progesterone in the management of postnatal mood disorders. J Psychosom Obstet Gynaecol 2001; 22: 49–55.
    OpenUrlPubMed
  79. ↵
    Lawrie TA, Hofmeyr GJ, DeJager M, Berk M, Paiker J, Viljoen E. A double-blind randomised placebo controlled trial of postnatal norethisterone enanthate: the effect on postnatal depression and serum hormones. Br J Obstet Gynaecol 1998; 105: 1082–90.
    OpenUrlPubMedWeb of Science
  80. ↵
    Cooper PJ, Murray L. The impact of psychological treatments of postnatal depression on maternal mood and infant development. In: Murray L, Cooper PJ, editors. Postpartum depression and child development London: Guilford Press, 1997.
  81. ↵
    Holden JM, Sagovsky R, Cox JL. Counselling in a general practice setting: controlled study of health visitor intervention in treatment of postnatal depression. BMJ 1989; 298: 223–6.
  82. ↵
    O’Hara MW, Stuart S, Gorman LL, Wenzel A. Efficacy of interpersonal psychotherapy for postpartum depression. Arch Gen Psychiatry 2000; 57: 1039–45.
    OpenUrlCrossRefPubMedWeb of Science
  83. ↵
    Chen CH, Tseng YF, Chou FH, Wang SY. Effects of support group intervention in postnatally distressed women: a controlled study in Taiwan. J Psychosom Res 2000; 49: 395–9.
    OpenUrlCrossRefPubMedWeb of Science
  84. ↵
    Fleming AS, Klein E, Corter C. The effects of a social support group on depression, maternal attitudes and behavior in new mothers. J Child Psychol Psychiatry 1992; 33: 685–98.
    OpenUrlCrossRefPubMedWeb of Science
  85. ↵
    Meager I, Milgrom J. Group treatment for postpartum depression: a pilot study. Aust N Z J Psychiatry 1996; 30: 852–60.
    OpenUrlAbstract/FREE Full Text
  86. ↵
    Misri S, Kostaras X, Fox D, Kostaras D. The impact of partner support in the treatment of postpartum depression. Can J Psychiatry 2000; 45: 554–8.
    OpenUrlPubMedWeb of Science
  87. ↵
    Wickberg B, Hwang CP. Counselling of postnatal depression: a controlled study on a population based Swedish sample. J Affect Disord 1996; 39: 209–16.
    OpenUrlCrossRefPubMedWeb of Science
  88. ↵
    Armstrong KL, Fraser JA, Dadds MR, Morris J. A randomized, controlled trial of nurse home visiting to vulnerable families with newborns. J Paediatr Child Health 1999; 35: 237–4.
    OpenUrlCrossRefPubMedWeb of Science
  89. ↵
    Corral M, Kuan A, Kostaras D. Bright light therapy’s effect on postpartum depression. Am J Psychiatry 2000; 157: 303–4.
    OpenUrlCrossRefPubMed
  90. ↵
    Field T, Grizzle N, Scafidi F, Schanberg S. Massage and relaxation therapies’ effects on depressed adolescent mothers. Adolescence 1996; 31: 903–11.
    OpenUrlPubMedWeb of Science
  91. ↵
    Rabheru K. The use of electroconvulsive therapy in special patient populations. Can J Psychiatry 2001; 46: 710–9.
    OpenUrlPubMedWeb of Science
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