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Research ArticleOriginal Article

Meta-Analysis of Prostate-Specific Antigen and Digital Rectal Examination as Screening Tests for Prostate Carcinoma

Kishor Mistry and Greg Cable
The Journal of the American Board of Family Practice March 2003, 16 (2) 95-101; DOI: https://doi.org/10.3122/jabfm.16.2.95
Kishor Mistry
MD, PhD
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Greg Cable
PhD
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  • Article
  • Figures & Data
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Article Figures & Data

Tables

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    Table 1.

    Detection Rate and Biopsies Performed to Detect Prostate Carcinoma (PCA).

    ReferencePopulation Size(all males)Age(years)Detection Rate(%)Localized PCA(% of Total)*Bx/PCA†
    Bangma et al141,726 Netherlands55 –763.8888.064.60
    Brett15211 Australian50 –791.423.67
    Bretton161,027 American40 –893.8064.405.77
    Gustafsson et al171,782 Swedish55 –702.715.71
    Higashihara et al7701 Japanese50 –921.858.92
    Horninger et al1821,078 Austrian45 –790.943.95
    Horninger et al1821,078 Austrian40 –652.7785.714.13
    Imai et al191,680 Japanese39 –890.898.80
    Imai et al203,276 Japanese40 –891.4060.785.52
    Jubelirer et al3142 American50 –8575.003.75
    Maattanen et al55,053 Finish55 –752.3490.003.80
    Reissigl et al212,272 Austrian40 –652.8586.003.97
    Stenman et al227,204 Finish45 –840.61
    Tsukamoto et al231,639 Japanese1.106.39
    Pooled results47,7911.8083.404.00
    • * % of local PCA = localized prostate carcinoma/total prostate carcinoma × 100.

    • † Bx/PCA = total biopsies performed/actual number of positive biopsies.

    • View popup
    Table 2.

    Positive Predictive Value, Sensitivity, and Specificity of Prostate-Specific Antigen (PSA) as Screening Parameter.

    ReferencePopulation with PSA > 4 ng/mL(%)Positive Predictive Value(%)Sensitivity(%)Specificity(%)
    Bangma et al1410.3130.90
    Brett159.5066.6718.00
    Bretton1613.0027.9192.31
    Gustafsson et al1717.1717.0080.00
    Higashihara et al711.2724.0092.3063.10
    Horninger et al188.8825.32
    Horninger et al1812.5022.18
    Imai et al194.4627.5073.3399.75
    Imai et al205.1345.1080.40
    Jubelirer et al312.6030.00100.00100.00
    Maattanen et al58.4727.00
    Reissigl et al2110.7418.00
    Stenman et al2257.0097.00
    Tsukamoto et al234.3023.2088.90
    Pooled results10.1025.1072.1093.20
    • Positive predictive value of PSA = percent of positive biopsies/total positive PSA.

    • View popup
    Table 3.

    Positive Predictive Value, Sensitivity and Specificity of Digital Rectal Examination (DRE) as a Screening Parameter.

    ReferencePopulation Abnormal(%)Positive Predictive Value(%)Sensitivity(%)Specificity(%)
    Bangma et al146.8433.06
    Brett1519.0066.6718.00
    Bretton167.60
    Gustafsson et al1727.39
    Higashihara et al719.3010.6069.2026.20
    Imai et al199.4113.3353.3399.54
    Imai et al2010.7817.2049.0093.33
    Jubelirer et al314.0822.2250.0050.00
    Reissigl et al215.00
    Tsukamoto et al234.21
    Pooled results5.0017.8053.2083.60
    • Positive predictive value of DRE = percent of positive biopsies/total positive DRE.

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The Journal of the American Board of Family Practice: 16 (2)
The Journal of the American Board of Family Practice
Vol. 16, Issue 2
1 Mar 2003
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Meta-Analysis of Prostate-Specific Antigen and Digital Rectal Examination as Screening Tests for Prostate Carcinoma
Kishor Mistry, Greg Cable
The Journal of the American Board of Family Practice Mar 2003, 16 (2) 95-101; DOI: 10.3122/jabfm.16.2.95

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Meta-Analysis of Prostate-Specific Antigen and Digital Rectal Examination as Screening Tests for Prostate Carcinoma
Kishor Mistry, Greg Cable
The Journal of the American Board of Family Practice Mar 2003, 16 (2) 95-101; DOI: 10.3122/jabfm.16.2.95
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