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Review ArticleClinical Review

The Pharmacologic Treatment of Depression

Barbara A. Majeroni and Andrea Hess
The Journal of the American Board of Family Practice March 1998, 11 (2) 127-139; DOI: https://doi.org/10.3122/15572625-11-2-127
Barbara A. Majeroni
From the Department of Family Medicine, State University of New York at Buffalo.
MD
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Andrea Hess
From the Department of Family Medicine, State University of New York at Buffalo.
PharmD
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Abstract

Background. Family physicians often provide the first line of treatment for patients with depression. Many effective drugs are now available for the pharmacologic treatment of depression.

Methods: We searched MEDLINE from 1991-96 under the topics of depressive disorders/treatment and antidepressant medications. Other sources were found by back-referencing from these references and from pharmacology texts.

Results: Although antidepressants appear to be equally effective, selective serotonin reuptake inhibitors are frequently the drugs of choice because of their safety profile and less troublesome side effects.

Conclusions: When prescribing antidepressant medications, the clinician must educate patients about potential side effects and about the amount of time that must be allowed for therapeutic efficacy. Drug interactions and concurrent medical conditions are important factors in the choice of an antidepressant.

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The Journal of the American Board of Family     Practice: 11 (2)
The Journal of the American Board of Family Practice
Vol. 11, Issue 2
1 Mar 1998
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The Pharmacologic Treatment of Depression
Barbara A. Majeroni, Andrea Hess
The Journal of the American Board of Family Practice Mar 1998, 11 (2) 127-139; DOI: 10.3122/15572625-11-2-127

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The Pharmacologic Treatment of Depression
Barbara A. Majeroni, Andrea Hess
The Journal of the American Board of Family Practice Mar 1998, 11 (2) 127-139; DOI: 10.3122/15572625-11-2-127
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