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Criterion Points Five years or less since reaction 2 Anaphylaxis, angioedema, or severe cutaneous adverse reaction such as Stevens- Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), or Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) 2 Treatment required for reaction 1 Points
0 = very low risk of positive penicillin allergy test; <1%
1 to 2 = low risk of positive penicillin allergy test; 5%
3 = moderate risk of positive penicillin allergy test; 20%
4 to 5 = high risk of positive penicillin allergy test; 50%- Table 2.
Demographic Characteristics of Study Participants from January 2021-January 2023, Compared Between Two Academic Primary Care Sites. P-values from Fisher’s Exact Test for Categorical Variables or 2-Sample T-test for Continuous Variables Comparing Site A to Site B. *P < .05
Total (n = 49) Site A (n = 30) Site B (n = 19) P-value % of total count 61% 39% Median age as of 3/1/23 (IQR) 53 (29) 53.5 (27.8) 52 (29.5) 0.296 Sex Male (%) 26 20 (67%) 6 (32%) 0.021* Female (%) 23 10 (33%) 13 (68%) Race White (%) 37 26 (87%) 11 (58%) 0.002* Asian (%) 5 4 (13%) 1 (5%) African-American (%) 3 0 (0%) 3 (16%) Other (%) 4 0 (0%) 4 (21%) Ethnicity Hispanic (%) 4 0 (0%) 4 (21%) 0.018* Non-Hispanic (%) 45 30 (100%) 15 (79%) Patients on medicaid or similar programs for low-income patients Yes 8 1 7 0.004* No 41 29 12 Other antibiotic allergies Yes 11 5 6 0.298 No 38 25 13 Abbreviation: IQR, Interquartile range.
- Table 3.
Results of 1-Week and 6-Month Follow-up Survey Questions for Patients Who Underwent DOC Between January 2021 and January 2023 at Two Academic Primary Care Sites
Survey Questions 1-Week follow up n = 23/49 (RR = 47%) Did you experience any rash, itching, or other adverse reaction in the past week that you believe is due to taking amoxicillin? YES 0 NO 23 Do you believe you are allergic to penicillin? YES 2 NO 21 Would you be willing to take penicillin if prescribed in the future? YES 23 NO 0 Do you think undergoing testing for penicillin allergy provides important information for your medical history? YES 23 NO 0 6-Month Follow Up n = 22/49 (RR = 45%) Have you taken a penicillin antibiotic since the oral challenge? YES 0 NO 22 Based on your answers to question 1, do you believe you are allergic to penicillin? YES 0 NO 22 Would you be willing to take penicillin if prescribed in the future? YES 21 NO 1 Abbreviation: RR, Response rate.
