Article Figures & Data
Tables
Total (n = 2,148) Mean (SD) or n (%) Age, mean (SD), years 62.8 (8.0) <65 1,273 (59.3) 65 to 75 719 (33.5) >75 156 (7.3) Sex Female 1,353 (63.0) Male 795 (37.0) Race Black 160 (7.4) White 1,787 (83.2) Other 201 (9.4) Ethnicity Hispanic 403 (18.8) Non-Hispanic 1,731 (80.6) Unknown 14 (0.6) Education <8th grade 81 (3.8) HS/GED 428 (19.9) College or higher 1,621 (75.5) Not reported 18 (0.8) Income <$40,000 636 (29.6) $40,000 to <$80,000 483 (22.5) $80,000 or more 942 (43.9) Not reported 87 (4.0) Cigarette smoker Current 120 (5.6) Former 629 (29.3) Never 1,390 (64.7) Not reported 9 (0.4) BMI <18.5 (underweight) 20 (0.9) 18.5–24.9 (healthy weight) 630 (29.3) 25.0–29.9 (overweight) 736 (34.3) ≥30.0 (obesity) 757 (35.2) Missing 5 (0.2) Watson method score Abnormal 581 (27.1) Normal 1,567 (72.9) Mendes-Santos method score Abnormal 453 (21.1) Normal 2,148 (78.9) Abbreviations: SD, Standard Deviation; HS/GED, High School/General Educational Development; BMI, Body Mass Index.
Hemoccult ICT Hemosure iFOB OC-Auto Micro FIT OC-Light S FIT QuickVue iFOB Difficulties n (%) n (%) n (%) n (%) n (%) None 1044 (48.6) 1540 (70.0) 1454 (67.7) 1419 (66.1) 1435 (66.8) Getting sample on stick 172 (8.0) Getting sample in collection window 306 (14.2) Collection window was too small 401 (18.7) It was messy 450 (20.9) 71 (3.3) 79 (3.7) 67 (3.1) 66 (3.1) Instructions were unclear 73 (3.4) 23 (1.1) 21 (1.0) 16 (0.7) 23 (1.1) Getting the cap off 66 (3.1) 53 (2.5) 165 (7.7) 43 (2.0) Deciding which cap to open Not asked Not asked 137 (6.4) Probing the stool multiple times 114 (5.3) 110 (5.1) 108 (5.0) Scraping the stool multiple times 178 (8.3) Liquid spilled from the tube 20 (0.9) 11 (0.5) 4 (0.2) 9 (0.4) Other 113 (5.3) 64 (3.0) 103 (4.8) 80 (3.7) 68 (3.2) *Could check any that applied.
Abbreviations: ICT, Immunochemical Test; iFOB, Immunochemical Fecal Occult Blood Test; FIT, Fecal Immunochemical Test.
Overall No Difficulty Some Difficulty N (%) N (%) N (%) P-values Hemoccult ICT errors 0.027* Yes 66 (3.2) 29 (2.4) 37 (4.2) No 2,005 (96.8) 1,156 (97.6) 849 (95.8) Hemosure iFOB errors 0.001* Yes 52 (2.5) 31 (1.9) 21 (4.7) No 1,996 (97.5) 1,570 (98.1) 426 (95.3) OC-Light S FIT errors <0.001† Yes 9 (0.4) 1 (0.1) 8 (1.6) No 2,041 (99.6) 1,545 (99.9) 496 (98.4) QuickVue iFOB errors <0.001* Yes 54 (2.6) 26 (1.7) 28 (5.5) No 1,994 (97.4) 1,510 (98.3) 484 (94.5) ↵*χ2 for some difficulty versus no difficulty.
↵†Fisher’s exact test for some difficulty versus no difficulty.
↵**No errors were noted for OC-Auto, because all vials were sent to the main pathology laboratory for analysis, even if it appeared no stool was in the vial.
Abbreviations: ICT, Immunochemical Test; iFOB, Immunochemical Fecal Occult Blood Test; FIT, Fecal Immunochemical Test.
- Table 4.
Factors Associated with Having Some Difficulty versus No Difficulty in Collection of FIT Sample (n = 2,148)*
Univariable Model Multivariable Model† Factors Odds Ratio (95% CI) P-values Odds Ratio (95% CI) P-values FIT brand <0.0001 Hemoccult ICT (n = 2,071) 4.17 (3.49-4.99) <0.0001 4.05 (3.34-4.85) <0.0001 Hemosure iFOB (n = 2,048) 0.74 (0.61-0.91) 0.003 0.72 (0.59-0.88) 0.001 OC-Light S FIT (n = 2,050) 0.99 (0.81-1.20) 0.887 0.98 (0.81-1.19) 0.832 QuickVue iFOB (n = 2,048) 1.02 (0.84-1.24) 0.838 0.98 (0.81-1.19) 0.827 OC-Auto Micro FIT (n = 2,052) Reference Reference Age, years 0.002 <65 (n = 1,273) 0.65 (0.52-0.81) 0.001 0.65 (0.51-0.83) 0.001 65 to 75 (n = 719) Reference Reference >75 (n = 156) 0.79 (0.52-1.20) 0.265 0.72 (0.46-1.14) 0.158 Education 0.045 ≤8th grade (n = 81) 0.76 (0.43-1.34) 0.342 1.00 (0.52-1.93) 0.996 HS/GED (n = 428) 0.56 (0.43-0.73) <0.0001 0.68 (0.49-0.93) 0.015 College or higher (n = 1,621) Reference Reference Income 0.007 <$40,000 (n = 636) 0.34 (0.23-0.51) <0.0001 0.60 (0.44-0.81) 0.001 $40,000 to <$80,000 (n = 483) 0.74 (0.48-1.14) 0.174 0.84 (0.63-1.13) 0.249 $80,000 or more (n = 942) Reference Reference FIT errors^ Yes 4.28 (2.80-6.55) <0.0001 3.90 (2.46-6.17) <0.0001 No Reference Reference Ethnicity Hispanic (n = 403) 0.65 (0.49-0.85) 0.002 Non-Hispanic/unknown (n = 1,745) Reference Sex Female (n = 1,353) 0.97 (0.68-1.37) 0.851 Male (n = 795) Reference Race White (n = 1,787) 1.22 (0.81-1.81) 0.341 Others (n = 201) 0.90 (0.54-1.52) 0.699 Black (n = 160) Reference Watson method score Abnormal (n = 581) 1.24 (0.85-1.81) 0.266 Normal (n = 1,567) Reference Mendes-Santos method score Abnormal (n = 453) 1.17 (0.77-1.76) 0.468 Normal (n = 1,695) Reference *Outcome variable having “some difficulty” versus “no difficulty” to collect the sample; Original scores ranged from 1 = “very easy” to 5 = “very difficult” by each FIT. Scores were collapsed into a dichotomous variable with scores of 2, 3, 4, and 5 being categorized as having “some difficulty,” and a score of 1 categorized as “no difficulty.”
↵†Generalized Linear Mixed Model.
^Each FIT was categorized as either having an error or not.
Abbreviations: ICT, Immunochemical Test; iFOB, Immunochemical Fecal Occult Blood Test; FIT, Fecal Immunochemical Test; CI, Confidence Interval.
