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Substance Enzymes Inhibited THC CYP3A4, CYP2D6 CBD CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, UGT1A9, and UGT2B7 Abbreviations: THC, tetrahydrocannabinol; CBD, cannabidiol.
Recommendation Grade Discuss known risks and benefits, evidence, safety concerns, and side effects of cannabis use A Screen all pre-surgical patients for the amount and frequency of their cannabis use, type of cannabis product, time of last consumption, and route of administration A Postpone procedure involving sedation if a patient experiences acute cannabis toxicity and has impairment in their decision-making capacity A Educate patients inquiring about cannabis use that there is weak but emerging evidence that cannabis can treat central pain caused by neuropathic pain as an adjunctive or third line treatment B Review and update patient medication lists when patients inquire about use of cannabis C
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- Article
- Abstract
- Introduction
- Cannabis Forms and Routes of Use
- Cannabis and Pain: What Do We Know? What Is in the Literature?
- Adverse Effects of Cannabis Used to Treat Pain
- Methodologic Limitations
- Additional Emerging Cautions with Cannabis Use
- Medication Interactions with Cannabis
- Conclusion: So, What Do We Tell Our Patients?
- Notes
- References
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