Skip to main content

Main menu

  • HOME
  • ARTICLES
    • Current Issue
    • Ahead of Print
    • Archives
    • Abstracts In Press
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • Other Publications
    • abfm

User menu

Search

  • Advanced search
American Board of Family Medicine
  • Other Publications
    • abfm
American Board of Family Medicine

American Board of Family Medicine

Advanced Search

  • HOME
  • ARTICLES
    • Current Issue
    • Ahead of Print
    • Archives
    • Abstracts In Press
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • JABFM on Bluesky
  • JABFM On Facebook
  • JABFM On Twitter
  • JABFM On YouTube
Research ArticleClinical Review

Denosumab versus Bisphosphonates for Reducing Fractures in Postmenopausal Women with Osteoporosis: A Meta-Analysis

Karissa A. Thal, Matthew Nudy, Eileen M. Moser and Andrew J. Foy
The Journal of the American Board of Family Medicine February 2023, 36 (1) 175-185; DOI: https://doi.org/10.3122/jabfm.2022.220099R1
Karissa A. Thal
From Department of Family and Community Medicine, Mount Nittany Physician Group, Bellefonte, PA (KAT); Department of Medicine, Division of Cardiology, Penn State College of Medicine, Hershey (MN); Department of Medicine, Penn State College of Medicine, Hershey (EMM); Departments of Medicine and Public Health Sciences, Penn State College of Medicine, Hershey (AJF).
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew Nudy
From Department of Family and Community Medicine, Mount Nittany Physician Group, Bellefonte, PA (KAT); Department of Medicine, Division of Cardiology, Penn State College of Medicine, Hershey (MN); Department of Medicine, Penn State College of Medicine, Hershey (EMM); Departments of Medicine and Public Health Sciences, Penn State College of Medicine, Hershey (AJF).
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eileen M. Moser
From Department of Family and Community Medicine, Mount Nittany Physician Group, Bellefonte, PA (KAT); Department of Medicine, Division of Cardiology, Penn State College of Medicine, Hershey (MN); Department of Medicine, Penn State College of Medicine, Hershey (EMM); Departments of Medicine and Public Health Sciences, Penn State College of Medicine, Hershey (AJF).
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew J. Foy
From Department of Family and Community Medicine, Mount Nittany Physician Group, Bellefonte, PA (KAT); Department of Medicine, Division of Cardiology, Penn State College of Medicine, Hershey (MN); Department of Medicine, Penn State College of Medicine, Hershey (EMM); Departments of Medicine and Public Health Sciences, Penn State College of Medicine, Hershey (AJF).
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Looker AC,
    2. Frenk SM
    . Percentage of adults aged 65 and over with osteoporosis or low bone mass at the femur neck or lumbar spine: United States, 2005–2010 [Internet]; 2015. Available from: https://www.cdc.gov/nchs/data/hestat/osteoporsis/osteoporosis2005_2010.htm.
  2. 2.↵
    1. Hughes DE,
    2. Mian M,
    3. Guilland-Cumming DF,
    4. Russell RG
    . The cellular mechanism of action of bisphosphonates. Drugs Exp Clin Res 1991;17:109–14.
    OpenUrlPubMed
  3. 3.↵
    Lexicomp. [Internet]. Denosumab; 2020. Available from: http://online.lexi.com/. Accessed April 27, 2020.
  4. 4.↵
    1. Hanley DA,
    2. Adachi JD,
    3. Bell A,
    4. Brown V
    . Denosumab: mechanism of action and clinical outcomes. Int J Clin Pract 2012;66:1139–46.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Tu KN,
    2. Lie JD,
    3. Wan CKV,
    4. et al
    . Osteoporosis: a review of treatment options. P T 2018;43:92–104.
    OpenUrlPubMed
  6. 6.↵
    1. Burke LA,
    2. Ryan AM
    . The complex relationship between cost and quality in US health care. AMA J Ethics 2014;16:124–30.
    OpenUrl
  7. 7.↵
    1. Cummings SR,
    2. Black DM,
    3. Nevitt MC,
    4. et al
    . Bone density at various sites for prediction of hip fractures. Lancet 1993;341:72–5.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. Marshall D,
    2. Johnell O,
    3. Wedel H
    . Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996;312:1254–9.
    OpenUrlAbstract/FREE Full Text
  9. 9.↵
    1. Liberati A,
    2. Altman DG,
    3. Tetzlaff J,
    4. et al
    . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 2009;151:W65–94.
    OpenUrlCrossRefPubMedWeb of Science
  10. 10.↵
    1. Vordemvenne T,
    2. Wähnert D,
    3. Klingebiel S,
    4. et al
    . Differentiation of traumatic osteoporotic and non-osteoporotic vertebral AO A3 fractures by analyzing the posterior edge morphology—a retrospective feasibility study. J Clin Med 2020;9:3910.
    OpenUrl
  11. 11.↵
    1. Higgins JPT,
    2. Altman DG,
    3. Gotzsche PC
    , Cochrane Statistical Methods Groupet al. The Cochrane Collaboration’s tool for assessing risk of bias in randomized trials. BMJ 2011;343:d5928.
    OpenUrlFREE Full Text
  12. 12.↵
    1. Miller PD,
    2. Bolognese MA,
    3. Lewiecki EM,
    4. et al
    . Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial. Bone 2008;43:222–9.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Brown JP,
    2. Prince RL,
    3. Deal C,
    4. et al
    . Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J Bone Miner Res 2009;24:153–61.
    OpenUrlCrossRefPubMedWeb of Science
  14. 14.↵
    1. Kendler DL,
    2. Roux C,
    3. Benhamou CL,
    4. et al
    . Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J Bone Miner Res 2010;25:72–81.
    OpenUrlPubMed
  15. 15.↵
    1. Freemantle N,
    2. Satram-Hoang S,
    3. Tang E-T
    , on behalf of the DAPS Investigators, et al. Final results of the DAPS (Denosumab Adherence Preference Satisfaction) study: a 24-month, randomized, crossover comparison with alendronate in postmenopausal women. Osteoporos Int 2012;23:317–26.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Recknor C,
    2. Czerwinski E,
    3. Bone HG,
    4. et al
    . Denosumab compared with ibandronate in postmenopausal women previously treated with bisphosphonate therapy. Obstetrics Gynecology 2013;121:1291–9.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Roux C,
    2. Hofbauer L,
    3. Ho P,
    4. et al
    . Denosumab compared with risedronate in postmenopausal women suboptimally adherent to alendronate therapy: efficacy and safety results from a randomized open-label study. Bone 2014;58:48–54.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Miller PD,
    2. Pannacciulli N,
    3. Brown JP,
    4. et al
    . Denosumab or zoledronic acid in postmenopausal women with osteoporosis previously treated with oral bisphosphonates. J Clin Endocrinology Metabolism 2016;101:3163–70.
    OpenUrl
  19. 19.↵
    1. Riaz H,
    2. Raza S,
    3. Khan MS,
    4. Riaz IB,
    5. Krasuski R
    . Impact of funding source on clinical trial results including cardiovascular outcomes trials. Am J Cardiol 2015;116:1944–7.
    OpenUrlPubMed
  20. 20.↵
    1. Bouxsein ML,
    2. Eastell R,
    3. Lui L-Y
    , FNIH Bone Quality Project, et al. Change in bone density and reduction in fracture risk: a meta-regression of published trials. J Bone Miner Res 2019;34:632–42.
    OpenUrlCrossRef
  21. 21.↵
    1. Wu J,
    2. Zhang Q,
    3. Yan G,
    4. Jin X
    . Denosumab compared to bisphosphonates to treat postmenopausal osteoporosis: a meta-analysis. J Orthop Surg Res 2018;13:194.
    OpenUrl
  22. 22.↵
    1. Beaudoin C,
    2. Jean S,
    3. Bessette L,
    4. Ste-Marie L-G,
    5. Moore L,
    6. Brown JP
    . Denosumab compared to other treatments to prevent or treat osteoporosis in individuals at risk of fracture: a systematic review and meta-analysis. Osteoporos Int 2016;27:2835–44.
    OpenUrl
  23. 23.↵
    1. Lin T,
    2. Wang C,
    3. Cai XZ,
    4. et al
    . Comparison of clinical efficacy and safety between denosumab and alendronate in postmenopausal women with osteoporosis: a meta-analysis. Int J Clin Pract 2012;66:399–408.
    OpenUrlCrossRefPubMed
  24. 24.↵
    1. Jackson RD,
    2. LaCroix AZ,
    3. Gass M,
    4. et al
    . Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669–83. Erratum in: N Engl J Med. 2006;354(10):1102.
    OpenUrlCrossRefPubMedWeb of Science
  25. 25.↵
    1. Prasad V,
    2. Vandross A,
    3. Toomey C,
    4. et al
    . A decade of reversal: an analysis of 146 contraindicated medical practices. Mayo Clin Proc 2013;88:790–8.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.↵
    1. Morizio P,
    2. Burkhart JI,
    3. Ozawa S
    . Denosumab: a unique perspective on adherence and cost-effectiveness compared with oral bisphosphonates in osteoporosis patients. Ann Pharmacother 2018;52:1031–41.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Ozaras N,
    2. Rezvani A
    . Diffuse skeletal pain after administration of alendronate. Indian J Pharmacol 2010;42:245–6.
    OpenUrlPubMed
  28. 28.↵
    1. Liberman UA,
    2. Weiss SR,
    3. Bröll J,
    4. et al
    . Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 1995;333:1437–44.
    OpenUrlCrossRefPubMedWeb of Science
  29. 29.↵
    Bone Health & Osteoporosis Foundation [Internet]. Side effects of bisphosphonates (alendronate, ibandronate, risedronate and zoledronic acid); 2022. Available from: https://www.bonehealthandosteoporosis.org/patients/treatment/medicationadherence/side-effects-of-bisphosphonates-alendronate-ibandronate-risedronate-and-zoledronic-acid/. Accessed August 18, 2022.
  30. 30.↵
    1. Hess LM,
    2. Jeter JM,
    3. Benham-Hutchins M,
    4. Alberts DS
    . Factors associated with osteonecrosis of the jaw among bisphosphonate users. Am J Med 2008;121:475–83.
    OpenUrlCrossRefPubMed
  31. 31.↵
    1. Yarom N,
    2. Shapiro CL,
    3. Peterson DE,
    4. et al
    . Medication-related osteonecrosis of the jaw: MASCC/ISOO/ASCO clinical practice guideline. J Clin Oncol 2019;37:2270–90.
    OpenUrl
  32. 32.↵
    Bone Health & Osteoporosis Foundation [Internet]. Denosumab (Prolia); 2022. Available from: https://www.bonehealthandosteoporosis.org/patients/treatment/medicationadherence/denosumab-prolia/. Accessed August 18, 2022.
  33. 33.↵
    1. Boquete-Castro A,
    2. Gómez-Moreno G,
    3. Calvo-Guirado JL,
    4. Aguilar-Salvatierra A,
    5. Delgado-Ruiz RA
    . Denosumab and osteonecrosis of the jaw: a systematic analysis of events reported in clinical trials. Clin Oral Implants Res 2016;27:367–75.
    OpenUrl
  34. 34.↵
    1. Villa JC,
    2. Gianakos A,
    3. Lane JM
    . Bisphosphonate treatment in osteoporosis: optimal duration of therapy and the incorporation of a drug holiday. HSS J 2016;12:66–73.
    OpenUrl
  35. 35.↵
    1. Gonzalez-Rodriguez E,
    2. Aubry-Rozier B,
    3. Stoll D,
    4. Zaman K,
    5. Lamy O
    . Sixty spontaneous vertebral fractures after denosumab discontinuation in 15 women with early-stage breast cancer under aromatase inhibitors. Breast Cancer Res Treat 2020;179:153–9.
    OpenUrl
  36. 36.↵
    American Society for Bone and Mineral Research [Internet]. Joint guidance on osteoporosis management in the era of COVID-19 from the ASBMR, AACE, Endocrine Society, ECTS & NOF; 2022. Available from: https://www.asbmr.org/about/statement-detail/joint-guidance-on-osteoporosis-management-covid-19. Accessed August 18, 2022.
PreviousNext
Back to top

In this issue

The Journal of the American Board of Family     Medicine: 36 (1)
The Journal of the American Board of Family Medicine
Vol. 36, Issue 1
January/February 2023
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • Index by author
  • Back Matter (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Board of Family Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Denosumab versus Bisphosphonates for Reducing Fractures in Postmenopausal Women with Osteoporosis: A Meta-Analysis
(Your Name) has sent you a message from American Board of Family Medicine
(Your Name) thought you would like to see the American Board of Family Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
5 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Denosumab versus Bisphosphonates for Reducing Fractures in Postmenopausal Women with Osteoporosis: A Meta-Analysis
Karissa A. Thal, Matthew Nudy, Eileen M. Moser, Andrew J. Foy
The Journal of the American Board of Family Medicine Feb 2023, 36 (1) 175-185; DOI: 10.3122/jabfm.2022.220099R1

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Denosumab versus Bisphosphonates for Reducing Fractures in Postmenopausal Women with Osteoporosis: A Meta-Analysis
Karissa A. Thal, Matthew Nudy, Eileen M. Moser, Andrew J. Foy
The Journal of the American Board of Family Medicine Feb 2023, 36 (1) 175-185; DOI: 10.3122/jabfm.2022.220099R1
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Methods
    • Results
    • Discussion
    • Appendix. Denosumab Search Terms and Appendix Figures 1-5
    • Notes
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Family Physicians Can/Should Do: What? Where? And How?
  • Google Scholar

More in this TOC Section

  • Interpretating Normal Values and Reference Ranges for Laboratory Tests
  • Non-Surgical Management of Urinary Incontinence
  • Screening and Diagnosis of Type 2 Diabetes in Sickle Cell Disease
Show more Clinical Review

Similar Articles

Keywords

  • Denosumab
  • Bisphosphonates
  • Meta-Analysis
  • Osteoporosis
  • Osteoporotic Fractures
  • Postmenopause

Navigate

  • Home
  • Current Issue
  • Past Issues

Authors & Reviewers

  • Info For Authors
  • Info For Reviewers
  • Submit A Manuscript/Review

Other Services

  • Get Email Alerts
  • Classifieds
  • Reprints and Permissions

Other Resources

  • Forms
  • Contact Us
  • ABFM News

© 2025 American Board of Family Medicine

Powered by HighWire