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Brief ReportBrief Report

Are Boosters Necessary If Adult Patients Do Not Achieve Seroconversion After 2 Doses of the MMR Vaccine?

Lakshmi Karra, Allison Costello, Brooke M. Trudeau and Morteza Khodaee
The Journal of the American Board of Family Medicine February 2023, 36 (1) 142-144; DOI: https://doi.org/10.3122/jabfm.2022.220285R1
Lakshmi Karra
From Faculty Development Fellow, University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (LK); Faculty Development Fellow, University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (AC); Clinical Pharmacy Specialist, Denver Health and Hospital Authority, Denver, CO (BMT); University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (MK).
MD, MS
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Allison Costello
From Faculty Development Fellow, University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (LK); Faculty Development Fellow, University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (AC); Clinical Pharmacy Specialist, Denver Health and Hospital Authority, Denver, CO (BMT); University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (MK).
MD, MBA
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Brooke M. Trudeau
From Faculty Development Fellow, University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (LK); Faculty Development Fellow, University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (AC); Clinical Pharmacy Specialist, Denver Health and Hospital Authority, Denver, CO (BMT); University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (MK).
PharmD
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Morteza Khodaee
From Faculty Development Fellow, University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (LK); Faculty Development Fellow, University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (AC); Clinical Pharmacy Specialist, Denver Health and Hospital Authority, Denver, CO (BMT); University of Colorado School of Medicine, Department of Family Medicine. AF Williams Clinic, Denver, CO (MK).
MD, MPH
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References

  1. 1.↵
    CDC. Child and Adolescent Immunization Schedule, 2022. Available from: https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html.
  2. 2.↵
    1. McLean HQ,
    2. Fiebelkorn AP,
    3. Temte JL
    , Centers for Disease Control and Preventionet al. Prevention of measles, rubella, congenital rubella syndrome, and mumps, 2013: summary recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2013;62:1–34.
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    1. Zucker JR,
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    3. Iwamoto M,
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    . Consequences of undervaccination—measles outbreak, New York City, 2018-2019. N Engl J Med 2020;382:1009–17.
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    1. Marin M,
    2. Marlow M,
    3. Moore KL,
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    . Recommendation of the Advisory Committee on Immunization Practices for use of a third dose of mumps virus-containing vaccine in persons at increased risk for mumps during an outbreak. MMWR Morb Mortal Wkly Rep 2018;67:33–8.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Connell AR,
    2. Connell J,
    3. Leahy TR,
    4. et al
    . Mumps outbreaks in vaccinated populations—is it time to re-assess the clinical efficacy of vaccines? Front Immunol 2020;11:2089.
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  6. 6.↵
    1. Dominguez A,
    2. Torner N,
    3. Castilla J,
    4. et al
    . Mumps vaccine effectiveness in highly immunized populations. Vaccine 2010;28:3567–70.
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  7. 7.↵
    1. Clemmons NS,
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    3. Patel M,
    4. et al
    . Incidence of measles in the United States, 2001-2015. JAMA 2017;318:1279–81.
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  8. 8.↵
    1. Fiebelkorn AP,
    2. Coleman LA,
    3. Belongia EA,
    4. et al
    . Mumps antibody response in young adults after a third dose of measles-mumps-rubella vaccine. Open Forum Infect Dis 2014;1:ofu094.
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  9. 9.↵
    1. Kremer JR,
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    . Waning antibodies in measles and rubella vaccinees–a longitudinal study. Vaccine 2006;24:2594–601.
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  10. 10.↵
    1. LeBaron CW,
    2. Forghani B,
    3. Beck C,
    4. et al
    . Persistence of mumps antibodies after 2 doses of measles-mumps-rubella vaccine. J Infect Dis 2009;199:552–60.
    OpenUrlCrossRefPubMedWeb of Science
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The Journal of the American Board of Family     Medicine: 36 (1)
The Journal of the American Board of Family Medicine
Vol. 36, Issue 1
January/February 2023
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Are Boosters Necessary If Adult Patients Do Not Achieve Seroconversion After 2 Doses of the MMR Vaccine?
Lakshmi Karra, Allison Costello, Brooke M. Trudeau, Morteza Khodaee
The Journal of the American Board of Family Medicine Feb 2023, 36 (1) 142-144; DOI: 10.3122/jabfm.2022.220285R1

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Are Boosters Necessary If Adult Patients Do Not Achieve Seroconversion After 2 Doses of the MMR Vaccine?
Lakshmi Karra, Allison Costello, Brooke M. Trudeau, Morteza Khodaee
The Journal of the American Board of Family Medicine Feb 2023, 36 (1) 142-144; DOI: 10.3122/jabfm.2022.220285R1
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Keywords

  • Immunization
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