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Brief ReportBrief Report

Risk of Thromboembolic Events Following COVID-19 Diagnosis Without Hospitalization

Katherine Schreck, Caroline Carlin and Jason Ricco
The Journal of the American Board of Family Medicine December 2022, 35 (6) 1163-1167; DOI: https://doi.org/10.3122/jabfm.2022.220180R2
Katherine Schreck
From Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN (KS, CC, JR).
MD
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Caroline Carlin
From Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN (KS, CC, JR).
PhD
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Jason Ricco
From Department of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN (KS, CC, JR).
MD, MPH
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  • Article
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  • References
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Article Figures & Data

Tables

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    Table 1.

    Patient Demographics

    COVID-19 positiveCOVID-19 negativeTotal sample
    Characteristic(n = 4528)(n = 162,955)(n = 167,483)Pa
    Any of these events occur: pulmonary embolism, cerebral infarction, thromboembolic event (%)1.4%1.5%1.5%0.517
    Age (mean, SD)48.2 (15.2)50.5 (15.5)50.5 (15.5)<0.001
    Female (%)63.4%62.2%62.2%0.107
    Race (%)
     White85.3%87.3%87.2%<0.001
     Black9.2%6.9%7.0%
     Asian4.0%4.4%4.4%
     Other/missing1.5%1.5%1.5%
    Hispanic (%)1.2%1.1%1.1%0.474
    English preferred (%)95.8%96.4%96.4%0.029
    Foreign born (%)9.8%8.9%9.0%0.037
    Partnered (%)58.2%58.5%58.5%0.707
    Neighborhood descriptors (mean, SD)
    Educational distribution
     Less than high school degree6.7% (6.6%)6.2% (6.6%)6.2% (6.6%)<0.001
     High school degree25.3% (9.9%)22.9% (10.6%)23.0% (10.6%)
     Bachelor’s degree22.3% (10.5%)25.1% (11.4%)25.1% (11.4%)
     Graduate degree10.3% (8.0%)12.9% (9.8%)12.8% (9.8%)
    Housing
     Crowded97.6% (3.9%)97.8% (3.8%)97.8% (3.8%)<0.001
     No vehicle6.1% (8.6%)5.9% (8.5%)5.9% (8.5%)0.109
     Under FPL9.4% (7.9%)8.6% (7.9%)8.6% (7.9%)<0.001
    Weight status
     Normal (BMI < 25)19.4%26.0%25.8%<0.001
     Overweight (25≤BMI < 30)30.8%30.5%30.5%
     Obese (BMI ≥ 30)49.8%43.5%43.7%
    Chronic condition indicators
     Asthma12.3%10.5%10.6%<0.001
     Cancer6.8%9.6%9.5%<0.001
     COPD3.1%3.9%3.9%0.005
     Diabetes14.9%14.6%14.7%0.648
     Bronchitis4.4%3.6%3.6%0.006
     Chronic respiratory failure0.4%0.4%0.4%0.837
     Emphysema1.4%1.6%1.6%0.151
     Pulmonary disease0.8%1.1%1.1%0.144
    Tobacco use
     Never56.9%55.6%55.6%<0.001
     Current user12.0%15.4%15.3%
     Former user31.2%29.0%29.0%
    • Abbreviations: FPL, federal poverty line; SD, standard deviation; BMI, body mass index; COPD, chronic obstructive pulmonary disease.

    • aP values document statistical significance of the difference between the COVID-19 positive and control populations. These statistics are computed using Pearson chi-square test for categorical variables, and analyses of variance for continuous variables.

    • View popup
    Table 2.

    Predicting Venous Thromboembolism: The Impact of a Positive COVID-19 Test Without Hospitalization

    Mean95% CI
    Propensity score
     Weighted0.0010−0.0210, 0.0231
     Unweighted0.0002−0.0036, 0.0040
    WeightedUnweighted
    Odds ratioPOdds ratioP
    Positive COVID-19 test, not hospitalized1.07040.9241.01440.912
    Age1.0300<0.0011.0298<0.001
    Female0.7674<0.0010.7575<0.001
    Racea    
     Black1.8613<0.0011.8832<0.001
     Asian1.13070.3971.10580.492
     Other/missing1.38700.0341.37600.040
    Hispanic1.20320.4041.22160.362
    English preferred0.98570.9220.95700.766
    Foreign born0.70710.0020.69810.002
    Partnered0.8265<0.0010.8189<0.001
    Neighborhood descriptors    
    Educational distributionb    
     High school degree0.99800.5610.99840.633
     Bachelor’s degree0.99600.1870.99630.231
     Graduate degree1.00080.8001.00090.779
    Housing
     Crowded0.99970.9570.99970.953
     No vehicle1.00310.2711.00320.257
     Under FPL0.99890.7570.99890.751
    Weight statusc    
     Overweight0.8152<0.0010.8163<0.001
     Obese0.97060.5650.97610.643
    Chronic condition indicators    
     Asthma1.06750.3111.06890.301
     Cancer1.8921<0.0011.8847<0.001
     COPD1.4306<0.0011.4142<0.001
     Diabetes1.5344<0.0011.5350<0.001
     Bronchitis1.17600.0601.20060.033
     Chronic respiratory disease1.58300.0061.60880.004
     Emphysema1.28040.0191.30500.012
     Pulmonary disease2.0220<0.0011.9792<0.001
    Smoking statusd    
     Current smoker1.3651<0.0011.3592<0.001
     Former smoker1.10090.0431.11000.028
    Constant0.0035<0.0010.0036<0.001
    • Abbreviations: FPL, federal poverty line; COPD, chronic obstructive pulmonary disease; CI, confidnce interval.

    • Notes: The top panel shows the average treatment effect (change in probability of any event due to a positive COVID-19 test). The bottom panel shows the comparison of propensity score weighted and unweighted odds ratios.

    • aWhite is reference value.

    • bLess than high school was omitted.

    • cNormal is reference value.

    • dNever is reference value.

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The Journal of the American Board of Family Medicine: 35 (6)
The Journal of the American Board of Family Medicine
Vol. 35, Issue 6
November/December 2022
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Risk of Thromboembolic Events Following COVID-19 Diagnosis Without Hospitalization
Katherine Schreck, Caroline Carlin, Jason Ricco
The Journal of the American Board of Family Medicine Dec 2022, 35 (6) 1163-1167; DOI: 10.3122/jabfm.2022.220180R2

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Risk of Thromboembolic Events Following COVID-19 Diagnosis Without Hospitalization
Katherine Schreck, Caroline Carlin, Jason Ricco
The Journal of the American Board of Family Medicine Dec 2022, 35 (6) 1163-1167; DOI: 10.3122/jabfm.2022.220180R2
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