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False Increase False Decrease Anemia (in particular those associated with increased red cell turnover) Anemia (from acute or chronic blood loss) Asplenia Splenomegaly Uremia Pregnancy Severe hypertriglyceridemia (typically >1750 mg/dL) Vitamin E ingestion Severe hyperbilirubinemia (typically >20 mg/dL) Medications (ribavirin, interferon-alpha) Chronic alcohol consumption Red blood cell transfusion Chronic salicylate ingestion Hemoglobin variants (most often with homozygous hemoglobinopathies) Chronic opioid ingestion Vitamin C ingestion Lead poisoning Adapted from Radin, 2013,4 with permission.
