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Research ArticleOriginal Research

Natural History of Back Pain in Older Adults over Five Years

Wendelien H. van der Gaag, Wendy T. M. Enthoven, Pim A. J. Luijsterburg, Jantine van Rijckevorsel-Scheele, Sita M.A. Bierma-Zeinstra, Arthur M. Bohnen, Maurits W. van Tulder and Bart W. Koes
The Journal of the American Board of Family Medicine November 2019, 32 (6) 781-789; DOI: https://doi.org/10.3122/jabfm.2019.06.190041
Wendelien H. van der Gaag
From Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands (WHvdG, WTME, PAJL, SMAB-Z, AMB, BWK); Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands (JvR-S); Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (SMAB-Z); Department of Health Sciences & Amsterdam Movement Sciences Institute, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (MWvT); Department of Physiotherapy & Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark (MWvT); Center for Muscle and Health, University of Southern Denmark, Odense, Denmark (BWK)
MD
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Wendy T. M. Enthoven
From Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands (WHvdG, WTME, PAJL, SMAB-Z, AMB, BWK); Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands (JvR-S); Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (SMAB-Z); Department of Health Sciences & Amsterdam Movement Sciences Institute, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (MWvT); Department of Physiotherapy & Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark (MWvT); Center for Muscle and Health, University of Southern Denmark, Odense, Denmark (BWK)
MD, PhD
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Pim A. J. Luijsterburg
From Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands (WHvdG, WTME, PAJL, SMAB-Z, AMB, BWK); Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands (JvR-S); Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (SMAB-Z); Department of Health Sciences & Amsterdam Movement Sciences Institute, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (MWvT); Department of Physiotherapy & Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark (MWvT); Center for Muscle and Health, University of Southern Denmark, Odense, Denmark (BWK)
PhD
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Jantine van Rijckevorsel-Scheele
From Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands (WHvdG, WTME, PAJL, SMAB-Z, AMB, BWK); Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands (JvR-S); Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (SMAB-Z); Department of Health Sciences & Amsterdam Movement Sciences Institute, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (MWvT); Department of Physiotherapy & Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark (MWvT); Center for Muscle and Health, University of Southern Denmark, Odense, Denmark (BWK)
PhD
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Sita M.A. Bierma-Zeinstra
From Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands (WHvdG, WTME, PAJL, SMAB-Z, AMB, BWK); Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands (JvR-S); Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (SMAB-Z); Department of Health Sciences & Amsterdam Movement Sciences Institute, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (MWvT); Department of Physiotherapy & Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark (MWvT); Center for Muscle and Health, University of Southern Denmark, Odense, Denmark (BWK)
PhD
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Arthur M. Bohnen
From Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands (WHvdG, WTME, PAJL, SMAB-Z, AMB, BWK); Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands (JvR-S); Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (SMAB-Z); Department of Health Sciences & Amsterdam Movement Sciences Institute, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (MWvT); Department of Physiotherapy & Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark (MWvT); Center for Muscle and Health, University of Southern Denmark, Odense, Denmark (BWK)
MD, PhD
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Maurits W. van Tulder
From Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands (WHvdG, WTME, PAJL, SMAB-Z, AMB, BWK); Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands (JvR-S); Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (SMAB-Z); Department of Health Sciences & Amsterdam Movement Sciences Institute, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (MWvT); Department of Physiotherapy & Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark (MWvT); Center for Muscle and Health, University of Southern Denmark, Odense, Denmark (BWK)
PhD
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Bart W. Koes
From Department of General Practice, Erasmus MC, University Medical Center, Rotterdam, The Netherlands (WHvdG, WTME, PAJL, SMAB-Z, AMB, BWK); Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, The Netherlands (JvR-S); Department of Orthopedics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands (SMAB-Z); Department of Health Sciences & Amsterdam Movement Sciences Institute, Faculty of Science, Vrije Universiteit Amsterdam, The Netherlands (MWvT); Department of Physiotherapy & Occupational Therapy, Aarhus University Hospital, Aarhus, Denmark (MWvT); Center for Muscle and Health, University of Southern Denmark, Odense, Denmark (BWK)
PhD
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Article Figures & Data

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    Figure 1.

    Flowchart of the initial patient recruitment process.

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    Figure 2.

    Clinical course. A: Average back pain in the previous week, mean ± SD; NRS, numeric rating scale (range 0 to 10). B: Disability in the previous week, mean ± SD; RMDQ, Roland Morris disability questionnaire (range 0 to 24). C: Quality of life on the physical (blue) and mental (red) summary scales, mean ± SD; SF-36, Short Form-36, physical and mental summary scale (range 0 to 100).

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    Figure 3.

    Medical consumption. A: Self-reported use of medication (% patients using this type of medication from all patients using medication). B: Self-reported consultations of health care professionals (% of total response). C: Self-reported diagnostic referrals (% of total response).

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    Table 1.

    Baseline Characteristics*

    CharacteristicsAll values, n = 675
    General
        Age in years, mean ± SD66.4 ± 7.6
        Male, n (%)274 (41)
        BMI, mean ± SD27.5 ± 4.7
        <Low education level, n (%)279 (41)
        Smoking, n (%)122 (18)
    Back pain
        Duration of back pain, n (%)
            <1 week62 (9)
            1 week–6 weeks273 (40)
            6 weeks–3 months104 (15)
            >3 months156 (23)
        Average back pain previous week (NRS), mean ± SD5.2 ± 2.7
        Radiating pain in the leg below the knee, n (%)205 (30)
        Disability (RMDQ), mean ± SD9.8 ± 5.8
        History of back pain, n (%)579 (86)
        Back surgery in the past, n (%)56 (8)
        Comorbidity musculoskeletal complaints, n (%)519 (77)
    Medical consumption
        Use of pain medication for back pain, n (%)485 (72)
        Care from a physical therapist, n (%)299 (44)
    Psychological factors
        Patients' expectation to recover of back pain, n (%)291 (43)
        Quality of life (SF-36) physical summary scale, mean ± SD43.2 ± 8.9
        Quality of life (SF-36) mental summary scale, mean ± SD49.6 ± 10.3
        Depressive symptomatology (CES-D), mean ± SD10.0 ± 7.8
        Kinesiophobia (FABQ), physical activity subscale, mean ± SD13.4 ± 5.8
        Pain catastrophizing (PCS), mean ± SD14.1 ± 10.6
        Attitude and beliefs about back pain (BBQ), mean ± SD26.4 ± 7.2
    • ↵* BMI, body mass index (kg/m2); CI, confidence interval; NRS, numeric rating scale (range, 0 to 10); RMDQ, Roland Morris disability questionnaire (range, 0 to 24); SF-36, Short Form-36; physical and mental summary scale (range, 0 to 100); CES-D, Center for Epidemiologic Studies Depression Scale (range, 0 to 60); FABQ, Fear-avoidance beliefs questionnaire, physical subscale (range, 0 to 28); PCS, Pain Catastrophizing Scale (range, 0 to 52); BBQ, Back beliefs questionnaire (range, 9 to 45).

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    Table 2.

    Five-Year Clinical Course and Medical Consumption

    OutcomesFollow-up time
    Baseline, n = 6753 months, n = 6266 months, n = 6129 months, n = 5851 year, n = 5912 years, n = 5013 years, n = 4294 years, n = 3925 years, n = 392*
    Five-year clinical course, mean (± SD)
        Average back pain previous week (NRS)5.2 (2.7)3.6 (2.8)3.4 (2.8)3.4 (2.9)3.3 (2.8)3.2 (2.9)3.4 (2.9)3.2 (2.9)3.0 (2.9)
        Disability (RMDQ)9.8 (5.8)7.8 (6.2)7.2 (6.1)7.2 (6.4)6.9 (6.4)7.0 (6.4)7.2 (6.4)7.0 (6.4)6.7 (6.2)
        Quality of life (SF-36) physical summary scale43.2 (8.9)47.0 (10.2)48.0 (10.3)48.0 (10.2)48.1 (10.3)48.0 (10.4)48.1 (10.4)48.1 (10.1)48.7 (9.8)
        Quality of life (SF-36) mental summary scale49.6 (10.3)49.5 (10.0)49.9 (9.4)49.7 (9.6)50.1 (9.4)49.1 (10.3)49.5 (9.7)49.5 (9.9)48.9 (10.1)
    Recovery, n (%)N/A239 (38)243 (40)220 (38)228 (39)195 (39)177 (41)166 (42)170 (43)
    Medical consumption, n (%)
        Use of medication for back pain485 (72)245 (39)205 (33)196 (34)178 (30)157 (31)138 (32)116 (30)98 (25)
            Paracetamol236 (49)126 (51)116 (57)121 (62)109 (61)79 (50)80 (58)71 (61)56 (57)
            NSAIDs277 (57)106 (43)89 (43)78 (40)65 (37)63 (40)52 (38)45 (39)44 (45)
            Opioids82 (17)51 (21)35 (17)31 (16)31 (17)42 (27)38 (28)26 (22)25 (26)
            Muscle relaxants, sleep medication37 (8)11 (4)12 (6)4 (2)5 (3)3 (2)4 (3)7 (6)0 (0)
            Antidepressants5 (1)7 (3)4 (2)4 (2)4 (2)6 (4)6 (4)4 (3)1 (1)
            Antiepileptics4 (1)4 (2)5 (2)6 (3)5 (3)1 (1)4 (3)2 (2)5 (5)
            Other10 (2)10 (4)7 (3)10 (5)8 (4)7 (4)5 (4)6 (5)7 (7)
        Care from healthcare professionals
            Care from a GPN/A161 (26)75 (12)68 (12)57 (10)71 (14)34 (8)38 (10)37 (9)
            Care from a physical therapist299 (44)220 (35)145 (24)105 (18)103 (17)92 (18)79 (18)61 (16)57 (15)
            Care from a medical specialist46 (7)68 (11)56 (9)49 (8)45 (8)40 (8)32 (7)25 (6)25 (6)
        Examinations related to back complaints
            X-rayN/A183 (29)57 (9)39 (7)30 (5)37 (7)20 (5)17 (4)18 (5)
            Blood tests92 (14)82 (13)46 (8)34 (6)26 (4)32 (6)25 (6)29 (7)25 (6)
            MRI/CT30 (4)42 (7)41 (7)25 (4)27 (5)29 (6)23 (5)15 (4)16 (4)
    • ↵* Due to missing values (range, 0% to 15%) these numbers may vary for different questions. NRS, numeric rating scale (range, 0 to 10); RMDQ, Roland Morris disability questionnaire (range, 0 to 24); SF-36, Short Form-36, physical and mental summary scale (range, 0 to 100); SD, standard deviation; NSAIDs, Nonsteroidal anti-inflammatory drugs; GP, general practitioners MRI, magnetic resonance imaging; CT, computed tomography. Percentages: % from total number of participants; except for the different types of pain medication: % of total amount of pain medication users.

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The Journal of the American Board of Family     Medicine: 32 (6)
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Vol. 32, Issue 6
November-December 2019
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Natural History of Back Pain in Older Adults over Five Years
Wendelien H. van der Gaag, Wendy T. M. Enthoven, Pim A. J. Luijsterburg, Jantine van Rijckevorsel-Scheele, Sita M.A. Bierma-Zeinstra, Arthur M. Bohnen, Maurits W. van Tulder, Bart W. Koes
The Journal of the American Board of Family Medicine Nov 2019, 32 (6) 781-789; DOI: 10.3122/jabfm.2019.06.190041

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Natural History of Back Pain in Older Adults over Five Years
Wendelien H. van der Gaag, Wendy T. M. Enthoven, Pim A. J. Luijsterburg, Jantine van Rijckevorsel-Scheele, Sita M.A. Bierma-Zeinstra, Arthur M. Bohnen, Maurits W. van Tulder, Bart W. Koes
The Journal of the American Board of Family Medicine Nov 2019, 32 (6) 781-789; DOI: 10.3122/jabfm.2019.06.190041
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