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Review ArticleClinical Review

Drug-Induced Hyperpigmentation: Review and Case Series

Rosa M. Giménez García and Sergio Carrasco Molina
The Journal of the American Board of Family Medicine July 2019, 32 (4) 628-638; DOI: https://doi.org/10.3122/jabfm.2019.04.180212
Rosa M. Giménez García
From the Department of Medicine, Dermatology and Toxicology, Faculty of Medicine, Valladolid, Spain (RMGG); Department of Dermatology, Hospital Universitario Rio Hortega, Valladolid, Spain (SCM).
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Sergio Carrasco Molina
From the Department of Medicine, Dermatology and Toxicology, Faculty of Medicine, Valladolid, Spain (RMGG); Department of Dermatology, Hospital Universitario Rio Hortega, Valladolid, Spain (SCM).
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Article Figures & Data

Figures

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  • Figure 1.
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    Figure 1.

    Minocycline induced facial hyperpygmentation.

  • Figure 2.
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    Figure 2.

    Hyperpigmentation due to lercanidipine.

  • Figure 3.
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    Figure 3.

    Clonazepam induced hyperpigmentation on extremities.

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    Figure 4.

    Drug fixed eruption induced by NSAIDs.

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    Figure 5.

    Bleomycin-induced flagelated hyperpigmentation.

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    Figure 6.

    Chloroquine induced hyperpigmentation.

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    Figure 7.

    Amiodarone -induced hyperpigmentation on hands.

Tables

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    Table 1.

    Drugs That May Cause Hyperpigmentation

    AntibioticsAntihypertensivesAnticonvulsantsPsychoactive drugsNSAIDsAntineoplastic agentsHeavy metalsOthers
    Amphotericin BAcebutololValproic acidAmitriptylineDerivatives of oxicam5 AminolevulinicArsenicAlitretinoin
    CeftriaxoneAmlodipineCarbamazepineCitalopramEtodolac5-FluorouracilIronAllopurinol
    CidofovirBetaxololPhenytoin lamotrigineClomipramineIbuprofenActinomycinMercuryAmiodarone
    ClofazimineBisoprololMephenytoinClonazepamKetoprofenBevacizumabGoldOral contraceptives
    DapsoneCaptoprilTiagabineChlorpromazineParacetamolBleomycinSilverAzathioprine
    DemeclocyclineClonidineTopiramateDesipramineSalicylatesBusulfanLeadCetirizine
    DoxycyclineDiltiazemDiazepamCapecitabineCevimeline
    EmtricitabineEsmololDonepezilCarboplatinCyclobenzaprine
    EnoxacinSpironolactoneEletriptanCyclophosphamideCyclosporine
    SparfloxacinIndapamideFluphenazineCisplatinDeferoxamine
    FoscarnetLabetalolFluoxetineChlorotrianiseneDicumarol
    GanciclovirLecanidipineFluvoxamineCorticosteroidsPhenazopyridine
    GrepafloxacinMethyldopaHaloperidolDiethylstilbestrolPhenolphthalein
    GriseofulvinMetoprololImipramineDocetaxelGlatiramer
    HydroxychloroquineMinoxidilKavaDoxorubicinHeroin
    IndinavirNebivololLevodopaEpirubicinHydroxychloroquine
    IsoniazidNisoldipineLoxapineStanozololHormones
    KetoconazoleOxprenololMesoridazineEstramustineInsulin
    LevofloxacinPropranololMethamphetamineEtoposideAlfa interferon
    LinezolidTelmisartanMethyldopaFloxuridineIsotretinoin
    LomefloxacinTimololMolindoneHydroxyureaLeflunomide
    MinocyclineOlanzapineIdarubicinLevobupivacaine
    OfloxacinParoxetineIfosfamideLidocaine
    OxytetracyclinePerphenazineImatinibMethimazole
    PyrimethaminePimozideIrinotecanMethysergide
    QuinacrineProchlorperazineLeuprolideMetoclopramide
    QuininePromazineMechlorethamineMethoxsalen
    RibavirinPromethazineMedroxyprogesteroneMucolytics
    RifampicinRisperidoneMercaptopurineNiacin
    RifapentineRopiniroleMethyl-aminolevulinateNicotine
    RitabutinThioridazineMethotrexateOrphenadrine
    RibavirinThiothixeneMitomycinPantoprazole
    SaquinavirTolcaponeMitotanePentazocine
    SertaconazoleTrifluoperazineMitoxantronePropylthiouracil
    SulfadiazineVenlafaxinePaclitaxelPsoralene
    TenofovirZaleplonPentostatinQuinidine
    TerbinafineProcarbazineRabeprazole
    TetracyclineTegafurRiluzole
    TigecyclineThiotepaSimvastatin
    TrimethoprimVinblastineSulfasalazine
    VoriconazoleVincristineTacrolimus
    ZidovudineVinorelbineToremifene
    ·Trioxsalen
    • NSAIDs, nonsteroidal anti-inflammatory drugs.

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The Journal of the American Board of Family     Medicine: 32 (4)
The Journal of the American Board of Family Medicine
Vol. 32, Issue 4
July-August 2019
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Drug-Induced Hyperpigmentation: Review and Case Series
Rosa M. Giménez García, Sergio Carrasco Molina
The Journal of the American Board of Family Medicine Jul 2019, 32 (4) 628-638; DOI: 10.3122/jabfm.2019.04.180212

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Drug-Induced Hyperpigmentation: Review and Case Series
Rosa M. Giménez García, Sergio Carrasco Molina
The Journal of the American Board of Family Medicine Jul 2019, 32 (4) 628-638; DOI: 10.3122/jabfm.2019.04.180212
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