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Brief ReportBrief Report

Dysrhythmias with Loperamide Used for Opioid Withdrawal

Nicki D. Vithalani, Christopher Heron, Ravishankar E. Rao, Anthony F. Cardell and Mark B. Stephens
The Journal of the American Board of Family Medicine November 2017, 30 (6) 832-834; DOI: https://doi.org/10.3122/jabfm.2017.06.170066
Nicki D. Vithalani
From the Penn State Health, State College, PA (NDV, CH, RER, MBS); Mount Nittany Physician Group, State College (AFC).
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Christopher Heron
From the Penn State Health, State College, PA (NDV, CH, RER, MBS); Mount Nittany Physician Group, State College (AFC).
MD
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Ravishankar E. Rao
From the Penn State Health, State College, PA (NDV, CH, RER, MBS); Mount Nittany Physician Group, State College (AFC).
MD
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Anthony F. Cardell
From the Penn State Health, State College, PA (NDV, CH, RER, MBS); Mount Nittany Physician Group, State College (AFC).
MD
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Mark B. Stephens
From the Penn State Health, State College, PA (NDV, CH, RER, MBS); Mount Nittany Physician Group, State College (AFC).
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References

  1. 1.↵
    U.S. Food & Drug Administration. FDA Drug Saf Communication: FDA warns about serious heart problems with high doses of the antidiarrheal medicine loperamide (Imodium), including from abuse and misuse. Silver Spring, MD, 2016.
  2. 2.↵
    Bluelight. Opioids: Using loperamide to combat methadone withdrawal? Available from: http://www.bluelight.org/vb/threads/623252. Accessed June 9, 2017.
  3. 3.↵
    1. Finch M
    . Opiate Addiction Support. How to use loperamide for opiate withdrawal. January 22, 2015. Available from: https://opiateaddictionsupport.com/how-to-use-loperamide-for-opiate-withdrawal/. Accessed June 9, 2017.
  4. 4.↵
    Bluelight. Opioids: Big and dandy loperamide addiction thread. 2012. Available from: http://www.bluelight.org/vb/threads/440234. Accessed June 9, 2017.
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    3. Sellers EM,
    4. et al
    . A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239–245.
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    World Health Organization. WHO Model List of Essential Medicines, 20th List. 2017. Available from: http://www.who.int/medicines/publications/essentialmedicines/en/.
  7. 7.↵
    Mylan Pharmaceuticals, Inc. Loperamide hydrochloride [prescribing information]. Morgantown, WV: Mylan Pharmaceuticals, Inc.; Oct 2016.
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    1. Awouters F,
    2. Megens A,
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    . Loperamide. Survey of studies on mechanism of its antidiarrheal activity. Digest Dis Sci 1993;38:977–995.
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    . Cardiac conduction disturbance after loperamide abuse. Clin Toxicol 2014;52:952–957.
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  10. 10.↵
    1. Eggleston W,
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    . Loperamide abuse associated with cardiac dysrhythmia and death. Ann Emerg Med 2017;69:83–86.
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  11. 11.↵
    1. Mukarram O,
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    . Loperamide induced torsades de pointes: A case report and review of the literature. Case Rep Med 2016;2016:4061980.
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    1. Lasoff DR,
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    . Ventricular dysrhythmias from loperamide abuse. J Emerg Med 2016;50:508–509.
    OpenUrl
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The Journal of the American Board of Family     Medicine: 30 (6)
The Journal of the American Board of Family Medicine
Vol. 30, Issue 6
November-December 2017
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Dysrhythmias with Loperamide Used for Opioid Withdrawal
Nicki D. Vithalani, Christopher Heron, Ravishankar E. Rao, Anthony F. Cardell, Mark B. Stephens
The Journal of the American Board of Family Medicine Nov 2017, 30 (6) 832-834; DOI: 10.3122/jabfm.2017.06.170066

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Dysrhythmias with Loperamide Used for Opioid Withdrawal
Nicki D. Vithalani, Christopher Heron, Ravishankar E. Rao, Anthony F. Cardell, Mark B. Stephens
The Journal of the American Board of Family Medicine Nov 2017, 30 (6) 832-834; DOI: 10.3122/jabfm.2017.06.170066
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Keywords

  • Cardiovascular System
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  • Loperamide
  • Opioids
  • Patient Care
  • Primary Health Care
  • Substance Withdrawal Syndrome
  • Torsades de Pointes
  • Toxicity

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