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Research ArticleOriginal Research

Physician Factors Associated with Polypharmacy and Potentially Inappropriate Medication Use

Kenya Ie, Maria Felton, Sydney Springer, Stephen A. Wilson and Steven M. Albert
The Journal of the American Board of Family Medicine July 2017, 30 (4) 528-536; DOI: https://doi.org/10.3122/jabfm.2017.04.170121
Kenya Ie
From the Department of Family Medicine, University of Pittsburgh, Pittsburgh (KI, MF, SS, SAW); University of Pittsburgh Graduate School of Public Health, Pittsburgh (KI, SMA); and UPMC St. Margaret, Pittsburgh, PA (MF, SS, SAW).
MD, PhD, MPH
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Maria Felton
From the Department of Family Medicine, University of Pittsburgh, Pittsburgh (KI, MF, SS, SAW); University of Pittsburgh Graduate School of Public Health, Pittsburgh (KI, SMA); and UPMC St. Margaret, Pittsburgh, PA (MF, SS, SAW).
PharmD, BCPS
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Sydney Springer
From the Department of Family Medicine, University of Pittsburgh, Pittsburgh (KI, MF, SS, SAW); University of Pittsburgh Graduate School of Public Health, Pittsburgh (KI, SMA); and UPMC St. Margaret, Pittsburgh, PA (MF, SS, SAW).
PharmD, BCPS
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Stephen A. Wilson
From the Department of Family Medicine, University of Pittsburgh, Pittsburgh (KI, MF, SS, SAW); University of Pittsburgh Graduate School of Public Health, Pittsburgh (KI, SMA); and UPMC St. Margaret, Pittsburgh, PA (MF, SS, SAW).
MD, MPH
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Steven M. Albert
From the Department of Family Medicine, University of Pittsburgh, Pittsburgh (KI, MF, SS, SAW); University of Pittsburgh Graduate School of Public Health, Pittsburgh (KI, SMA); and UPMC St. Margaret, Pittsburgh, PA (MF, SS, SAW).
PhD
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    Table 1.

    Characteristics of Patients (n = 932) and Visits (n = 2,103) Seen by 61 Participating Physicians

    Patient characteristics
        Age (years)
            65–74625 (67.1)
            ≥75307 (32.9)
        Female sex591 (63.4)
        Race
            White521 (55.9)
            Black380 (40.8)
            Other*31 (3.3)
        Index conditions
            Hypertension794 (85.2)
            Hyperlipidemia618 (66.3)
            Osteoarthritis506 (54.3)
            Gastroesophageal reflux363 (38.9)
            Diabetes mellitus334 (35.8)
            Depression315 (33.8)
        Commonly prescribed PIMs†
        Cyclobenzaprine45 (4.8)
        Meclizine39 (4.2)
        Hydroxyzine35 (3.8)
        Estrogens33 (3.5)
        Clonazepam29 (3.1)
        Paroxetine29 (3.1)
        Diphenhydramine28 (3.0)
        Lorazepam26 (2.8)
        Amitriptyline24 (2.6)
        Zolpidem16 (1.7)
    Encounter characteristics
        Prescriptions per visit
            0–4283 (13.5)
            5–9774 (36.8)
            10–14690 (32.8)
            ≥15356 (16.9)
        PIMs per visit
            01357 (64.5)
            1–3712 (33.9)
            4–633 (1.6)
            ≥71 (0.1)
    • Data are number (%) of patients or visits.

    • ↵* “Other” includes Asian and others.

    • ↵† Potentially inappropriate medications (PIMs) were defined based on the table 2 of 2015 American Geriatrics Society Beers Criteria for Potentially Inappropriate Medication Use in Older Adults.6

    • View popup
    Table 2.

    Physician Survey Responses (n = 61)

    Physician characteristics
        Age (years), mean (SD)36.1 (10.6)
        Female sex, n (%)30 (49.9)
        Years since graduation, mean (SD)9.7 (10.1)
        Position, n (%)
            Resident38 (62.3)
            Fellow/Faculty23 (37.7)
    Patient panel characteristics* (%), mean (SD)
        Patients ≥75 years old34.1 (17.6)
        Minority patients (black and others)46.0 (24.7)
    Item responses
        Perceived importance/confidence for deprescribing, mean (SD) (1 = not at all, 5 = very much)
            How important is it for you to deprescribe for patients 65 years or older in outpatient settings?4.4 (0.7)
            How confident are you in deprescribing for patients 65 years or older in outpatient settings?3.7 (1.0)
        Importance of 9 triggers for deprescribing,† mean (SD) (1 = not important, 5 = very important)
            Symptoms possibly related to medication4.8 (0.5)
            Cognitive impairment4.6 (0.7)
            Limited life expectancy4.6 (0.7)
            Wishes of patient/family4.5 (0.8)
            Functional dependency4.4 (0.7)
            Number of medications4.4 (0.8)
            Older age4.2 (0.9)
            Budgetary considerations4.2 (0.9)
            Number of chronic conditions4.1 (0.9)
        Importance of 6 barriers for deprescribing,‡ mean (SD) (1 = not important, 5 = very important)
            Patients belief that drugs might help3.6 (0.9)
            Lack of time3.5 (1.1)
            Medications started by other doctor3.5 (1.0)
            Lack of benefit/risk information about deprescribing2.9 (1.2)
            Lack of experience2.6 (1.4)
            Patients belief that you are giving up on them2.6 (1.2)
    • ↵* Data obtained from health record review.

    • ↵† “How important are the following factors for you to consider deprescribing?”

    • ↵‡ “To what extent do the following factors make you less likely to deprescribe?”

    • View popup
    Table 3.

    Multivariable Regression: Factors Associated with Physicians' Numbers of Prescriptions and Potentially Inappropriate Medication Orders

    VariablesPrescriptionsPIM Orders
    Lack of benefit/risk information about deprescribing*−0.40 (0.16)†−0.06 (0.03)†
    Number of medications*−0.67 (0.24)†−0.07 (0.04)
    Proportion of minority patients−3.72 (0.81)†−0.34 (0.14)†
    Proportion of patients aged ≥75−2.92 (1.13)†−0.45 (0.20)†
    Use of the Beers List‡−0.17 (0.08)
    Intercept16.31 (1.32)†1.40 (0.24)†
    Adjusted R2 (AIC)0.3939 (228)0.2062 (12.4)
    • Data are β (standard error). All variables included in the fitted models are reported in this table.

    • ↵* The importance of triggers/barriers were assessed using 5-point Likert scales ranging from 1(Not important) to 5(very important).

    • ↵† P < .05.

    • ↵‡ Reference group includes those physicians who did not use the Beers List.

    • AIC, Akaike information criterion; PIM, potentially inappropriate medication.

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The Journal of the American Board of Family     Medicine: 30 (4)
The Journal of the American Board of Family Medicine
Vol. 30, Issue 4
July-August 2017
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Physician Factors Associated with Polypharmacy and Potentially Inappropriate Medication Use
Kenya Ie, Maria Felton, Sydney Springer, Stephen A. Wilson, Steven M. Albert
The Journal of the American Board of Family Medicine Jul 2017, 30 (4) 528-536; DOI: 10.3122/jabfm.2017.04.170121

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Physician Factors Associated with Polypharmacy and Potentially Inappropriate Medication Use
Kenya Ie, Maria Felton, Sydney Springer, Stephen A. Wilson, Steven M. Albert
The Journal of the American Board of Family Medicine Jul 2017, 30 (4) 528-536; DOI: 10.3122/jabfm.2017.04.170121
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Keywords

  • Deprescribing
  • Linear Models
  • Physicians
  • Polypharmacy
  • Potentially Inappropriate Medication List
  • Risk Assessment
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