Skip to main content

Main menu

  • HOME
  • ARTICLES
    • Current Issue
    • Ahead of Print
    • Archives
    • Abstracts In Press
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • Other Publications
    • abfm

User menu

Search

  • Advanced search
American Board of Family Medicine
  • Other Publications
    • abfm
American Board of Family Medicine

American Board of Family Medicine

Advanced Search

  • HOME
  • ARTICLES
    • Current Issue
    • Ahead of Print
    • Archives
    • Abstracts In Press
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • JABFM on Bluesky
  • JABFM On Facebook
  • JABFM On Twitter
  • JABFM On YouTube
Review ArticleClinical Review

Management of Chronic Hepatitis B: An Overview of Practice Guidelines for Primary Care Providers

Steven-Huy Han and Tram T. Tran
The Journal of the American Board of Family Medicine November 2015, 28 (6) 822-837; DOI: https://doi.org/10.3122/jabfm.2015.06.140331
Steven-Huy Han
From the UCLA Medical Center, Pfleger Liver Institute, Los Angeles, CA (S-HH); and the Liver Disease and Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA (TTT).
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tram T. Tran
From the UCLA Medical Center, Pfleger Liver Institute, Los Angeles, CA (S-HH); and the Liver Disease and Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA (TTT).
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • References
  • Info & Metrics
  • PDF
Loading

Abstract

Despite the introduction of hepatitis B virus (HBV) vaccination programs, chronic hepatitis B (CHB) remains an important disease burden worldwide and in the United States. A number of clinical practice guidelines are available to assist in the clinical management of CHB by providing recommendations regarding screening and diagnosis, treatment indications, and the choice, duration, and monitoring of treatment. Adherence to these guidelines has proven beneficial in terms of better treatment compliance, improved clinical outcomes, and lower likelihoods of emergency admission. This review summarizes current recommendations from the major clinical CHB practice guidelines and presents a simple algorithm for the treatment of patients with CHB to help primary care providers make informed choices in clinical practice. In general, antiviral treatment should be initiated in patients with CHB who have a high risk of liver-related morbidity and who are likely to respond to treatment, that is, patients with persistently elevated serum HBV DNA and either increased serum alanine aminotransferase concentrations or advanced liver disease. In patients who are eligible for antiviral therapy, treatment should be initiated with one of the recommended first-line therapies (pegylated interferon-α, entecavir, or tenofovir), and treatment efficacy should be monitored regularly for serum HBV DNA, alanine aminotransferase, and serologic responses. Patients who are not immediately considered for treatment should be monitored and started on antiviral therapy in case of disease progression. A number of issues in CHB management remain controversial or unresolved, such as identifying treatment candidates, managing partial or nonresponders, and predicting treatment response; we discuss some of the latest evidence around these topics.

  • Health Care Providers
  • Hepatitis B
  • Chronic
  • Practice Guideline
  • Primary Health Care
View Full Text
PreviousNext
Back to top

In this issue

The Journal of the American Board of Family     Medicine: 28 (6)
The Journal of the American Board of Family Medicine
Vol. 28, Issue 6
November-December 2015
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • Index by author
  • Back Matter (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Board of Family Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Management of Chronic Hepatitis B: An Overview of Practice Guidelines for Primary Care Providers
(Your Name) has sent you a message from American Board of Family Medicine
(Your Name) thought you would like to see the American Board of Family Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
1 + 9 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Management of Chronic Hepatitis B: An Overview of Practice Guidelines for Primary Care Providers
Steven-Huy Han, Tram T. Tran
The Journal of the American Board of Family Medicine Nov 2015, 28 (6) 822-837; DOI: 10.3122/jabfm.2015.06.140331

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Management of Chronic Hepatitis B: An Overview of Practice Guidelines for Primary Care Providers
Steven-Huy Han, Tram T. Tran
The Journal of the American Board of Family Medicine Nov 2015, 28 (6) 822-837; DOI: 10.3122/jabfm.2015.06.140331
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Markers of HBV Infection and CHB Disease Progression
    • HBV Screening
    • Overview Management of CHB
    • Special Considerations and Unresolved Issues in CHB Management
    • Treatment Duration and Stopping Rules
    • Role of Noninvasive Assessment of Liver Disease
    • HCC Screening and the Role of HCC Risk Scores
    • Directions for Future Research
    • New Treatments for CHB
    • Acknowledgments
    • Notes
    • References
  • Figures & Data
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • New Tools and Approaches for Family Physicians
  • Google Scholar

More in this TOC Section

  • Interpretating Normal Values and Reference Ranges for Laboratory Tests
  • Non-Surgical Management of Urinary Incontinence
  • Screening and Diagnosis of Type 2 Diabetes in Sickle Cell Disease
Show more Clinical Review

Similar Articles

Keywords

  • Health Care Providers
  • Hepatitis B
  • Chronic
  • Practice Guideline
  • Primary Health Care

Navigate

  • Home
  • Current Issue
  • Past Issues

Authors & Reviewers

  • Info For Authors
  • Info For Reviewers
  • Submit A Manuscript/Review

Other Services

  • Get Email Alerts
  • Classifieds
  • Reprints and Permissions

Other Resources

  • Forms
  • Contact Us
  • ABFM News

© 2025 American Board of Family Medicine

Powered by HighWire