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Review ArticleClinical Review

Lifetime Follow-up Care After Childhood Cancer

Richard I. Haddy and Theresa B. Haddy
The Journal of the American Board of Family Medicine September 2010, 23 (5) 647-654; DOI: https://doi.org/10.3122/jabfm.2010.05.100031
Richard I. Haddy
MD
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Theresa B. Haddy
MD
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  • Article
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Article Figures & Data

Tables

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    Table 1.

    Surveillance Epidemiology and End Results Age-Adjusted Childhood Cancer Incidence* among the US Population for All Races and Sexes, 2002 to 2006 by Primary Cancer Site3

    Incidence by Age
    0–14 Years0–19 Years
    All sites, all races15.116.6
    Leukemia5.04.5
    Acute lymphoblastic leukemia4.03.4
    Brain and nervous system3.22.9
    Hodgkin lymphoma0.61.2
    Soft tissue1.01.1
    Non-Hodgkin lymphoma0.91.1
    Bone and joint0.70.9
    Kidney and renal pelvis0.80.6
    • * Rates are per 100,000 and are age-adjusted to the 2000 US population.

    • View popup
    Table 2.

    Surveillance Epidemiology and End Results Age-Adjusted Childhood Cancer Death Rates* among the US Population for All Races and Sexes, 1975 and 2006 by Primary Cancer Site

    Death Rates by Age
    0–14 Years0–19 Years
    1975200619752006
    All sites, all races4.92.25.12.5
    Brain and nervous system1.00.60.90.7
    Leukemia2.10.72.00.7
    Acute lymphoblastic leukemia1.20.31.00.3
    Soft tissue0.10.10.20.2
    Kidney and renal pelvis0.20.10.10.1
    Non-Hodgkin lymphoma0.40.10.40.1
    Hodgkin lymphoma0.0—0.10.0
    • * Rates are per 100,000 and are age-adjusted to the 2000 US population.

    • View popup
    Table 3.

    Surveillance Epidemiology and End Results 5-Year Survival Rates* among the US Population, 1975 to 1977 and 1999 to 2005, by Selected Primary Cancer Site

    Survival Rates by Age (%)
    0–14 Years0–19 Years
    1975–19771999–20051975–19771999–2005
    All sites, all races58.181.361.681.0
    Hodgkin lymphoma80.595.486.095.5
    Wilms tumor73.191.272.691.2
    Acute lymphoblastic leukemia57.689.054.185.1
    Non-Hodgkin lymphoma43.586.344.684.4
    Leukemia50.483.645.578.7
    Soft tissue61.081.065.275.6
    Brain and central nervous system56.973.858.874.2
    Neuroblastoma52.474.252.773.9
    Bone and joint49.971.850.468.5
    Acute myeloid leukemia18.860.218.755.0
    • * Rates are based on follow-up of patients into 2006.

    • View popup
    Table 4.

    Childhood Cancers in Diagnostic Groups According to the International Classification of Childhood Cancer14

    ClassificationType(s) of Cancer
    ILeukemias, myeloproliferative, and myelodysplastic diseases
    IILymphomas and reticuloendothelial neoplasms
    IIICentral nervous system and other intracranial and intraspinal neoplasms
    IVNeuroblastoma and other peripheral nervous cell tumors
    VRetinoblastoma
    VIRenal tumors
    VIIHepatic tumors
    VIIIMalignant bone tumors
    IXSoft tissue and other extraosseous sarcomas
    XGerm cell tumors, trophoblastic tumors, and neoplasms of gonads
    • View popup
    Table 5.

    Assessment of Late Effects*

    ComplicationSurveillanceTreatment Modality
    Growth failureHistory/examinationChemotherapy
    Cranial radiation
    Intellectual functionPsychiatric testCranial radiation
    Neurological toxicityNeurologic examinationCranial radiation
    Vincristine
    DentalExaminationChemotherapy
    CleaningCranial radiation
    Male infertilityLH, FSHAbdominal/pelvic radiation
    TestosteroneCyclophosphamide
    Sperm countDoxorubicin/daunomycin
    Female infertilityLH, FSHAbdominal/pelvic radiation
    EstradialCyclophosphamide
    Doxorubicin/daunomycin
    CardiacECG, echocardiogramDoxorubicin/daunomycin
    BladderUrinalysisCyclophosphamide
    Ifosphamide
    LungChest radiographBuslfan
    LiverLFTsMethotrexate
    BoneDEXA scanPrednisone/dexamethasone
    Methotrexate
    Eye (cataracts)Visual acuityPrednisone/dexamethasone
    Ear (hearing)AudiogramCisplatinum/carboplatinum
    Second neoplasmsExaminationRadiation
    Blood countCyclophosphamide
    UrinalysisDoxorubicin/daunomycin
    RecurrenceHistory/examination
    • * As recommended in “Long-Term Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers,” published by the Children's Oncology Group in 2008 (www.survivorshipguidelines.org).

    • LH, luteinizing hormone; FSH, follicle-stimulating hormone; ECG, electrocardiogram; LFT, liver function test; DEXA, dual energy x-ray absorptiometry.

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The Journal of the American Board of Family Medicine: 23 (5)
The Journal of the American Board of Family Medicine
Vol. 23, Issue 5
September-October 2010
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Lifetime Follow-up Care After Childhood Cancer
Richard I. Haddy, Theresa B. Haddy
The Journal of the American Board of Family Medicine Sep 2010, 23 (5) 647-654; DOI: 10.3122/jabfm.2010.05.100031

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Lifetime Follow-up Care After Childhood Cancer
Richard I. Haddy, Theresa B. Haddy
The Journal of the American Board of Family Medicine Sep 2010, 23 (5) 647-654; DOI: 10.3122/jabfm.2010.05.100031
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