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Review ArticleClinical Review

The Toxicity of Diesel Exhaust: Implications for Primary Care

Irina N. Krivoshto, John R. Richards, Timothy E. Albertson and Robert W. Derlet
The Journal of the American Board of Family Medicine January 2008, 21 (1) 55-62; DOI: https://doi.org/10.3122/jabfm.2008.01.070139
Irina N. Krivoshto
BA
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John R. Richards
MD
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Timothy E. Albertson
MD, MPH, PhD
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Robert W. Derlet
MD
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References

  1. ↵
    Gilman P. Health assessment document for diesel engine exhaust, EPA/600/8–90/057F. Washington, DC: US Environmental Protection Agency; 2002.
  2. ↵
    Zielinska B, Sagebiel J, McDonald JD, Whitney K, Lawson DR. Emission rates and comparative chemical composition from selected in-use diesel and gasoline-fueled vehicles. J Air Waste Manag Assoc 2004; 54: 1138–50.
    OpenUrlPubMed
  3. ↵
    Heinrich J, Wichmann HE. Traffic related pollutants in Europe and their effect on allergic disease. Curr Opin Allergy Clin Immunol 2004; 4: 341–8.
    OpenUrlCrossRefPubMed
  4. ↵
    Kagawa J. Health effects of diesel exhaust emissions-a mixture of air pollutants of worldwide concern. Toxicology 2002; 181–182: 349–53.
    OpenUrl
  5. ↵
    Kuehni CE, Strippoli MP, Zwahlen M, Silverman M. Association between reported exposure to road traffic and respiratory symptoms in children: evidence of bias. Int J Epidemiol 2006; 35: 779–86.
    OpenUrlAbstract/FREE Full Text
  6. ↵
    California Air Resources Board. Emission reduction plan for ports and goods movement. Available at http://www.arb.ca.gov/planning/gmerp/march21plan/docs/resolution_06-14.pdf. Accessed December 28, 2006.
  7. ↵
    Corfa E, Maury F, Segers P, Fresneau A, Albergel A. Short-range evaluation of air pollution near bus and railway stations. Sci Total Environ 2004; 334–335: 223–30.
    OpenUrl
  8. ↵
    Cyrys J, Pitz M, Bischof W, Wichmann HE, Heinrich J. Relationship between indoor and outdoor levels of fine particle mass, particle number concentrations and black smoke under different ventilation conditions. J Expo Anal Environ Epidemiol 2004; 14: 275–83.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    Peters A, Dockery DW, Muller JE, Mittleman MA. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 2001; 103: 2810–5.
    OpenUrlAbstract/FREE Full Text
  10. ↵
    Peters A, von Klot S, Heier M, et al. Cooperative Health Research in the Region of Augsburg Study Group. Exposure to traffic and the onset of myocardial infarction. N Engl J Med 2004; 351: 1721–30.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    Mills NL, Tornqvist H, Gonzalez MC, et al. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 2007; 357: 1075–82.
    OpenUrlCrossRefPubMed
  12. ↵
    Mittleman MA. Air pollution, exercise, and cardiovascular risk. N Engl J Med 2007; 357: 1147–9.
    OpenUrlCrossRefPubMed
  13. ↵
    Miller KA, Siscovick DS, Sheppard L, et al. Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 2007; 356: 447–58.
    OpenUrlCrossRefPubMedWeb of Science
  14. ↵
    Le Tertre A, Medina S, Samoli E, et al. Short-term effects of particulate air pollution on cardiovascular diseases in eight European cities. J Epidemiol Community Health 2002; 56: 773–9.
    OpenUrlAbstract/FREE Full Text
  15. ↵
    Peters A, von Klot S, Heier M, et al. Exposure to traffic and the onset of myocardial infarction. N Engl J Med 2004; 351: 1721–30.
    OpenUrlCrossRefPubMedWeb of Science
  16. ↵
    Minami M, Endo T, Hamaue N, et al. Electrocardiographic changes induced by diesel exhaust particles (DEP) in guinea pigs. Res Commun Mol Pathol Pharmacol 1999; 105: 67–76.
    OpenUrlPubMed
  17. ↵
    Sakakibara M, Minami M, Endo T, et al. Biological effects of diesel exhaust particles (DEP) on isolated cardiac muscle of guinea pigs. Res Commun Mol Pathol Pharmacol 1994; 86: 99–110.
    OpenUrlPubMedWeb of Science
  18. ↵
    Wold LE, Simkhovich BZ, Kleinman MT, et al. In vivo and in vitro models to test the hypothesis of particle-induced effects on cardiac function and arrhythmias. Cardiovasc Toxicol 2006; 6: 69–78.
    OpenUrlCrossRefPubMedWeb of Science
  19. ↵
    Anselme F, Loriot S, Henry JP, et al. Inhalation of diluted diesel engine emission impacts heart rate variability and arrhythmia occurrence in a rat model of chronic ischemic heart failure. Arch Toxicol 2007; 81: 299–307.
    OpenUrlCrossRefPubMedWeb of Science
  20. ↵
    Okayama Y, Kuwahara M, Suzuki AK, Tsubone H. Role of reactive oxygen species on diesel exhaust particle-induced cytotoxicity in rat cardiac myocytes. J Toxicol Environ Health A 2006; 69: 1699–710.
    OpenUrlCrossRefPubMedWeb of Science
  21. ↵
    Mamessier E, Nieves A, Vervloet D, Magnan A. Diesel exhaust particles enhance T-cell activation in severe asthmatics. Allergy 2006; 61: 581–8.
    OpenUrlCrossRefPubMedWeb of Science
  22. ↵
    Nemmar A, Hoet PH, Vermylen J, Nemery B, Hoylaerts MF. Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters. Circulation 2004; 110: 1670–7.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    Peters A, Liu E, Verrier RL. Air pollution and incidence of cardiac arrhythmia. Epidemiology 2000; 11: 11–7.
    OpenUrlCrossRefPubMedWeb of Science
  24. ↵
    Zanobetti A, Schwartz J. Cardiovascular damage by airborne particles: are diabetics more susceptible? Epidemiology 2002; 13: 588–92.
    OpenUrlCrossRefPubMedWeb of Science
  25. ↵
    Pekkanen J, Peters A, Hoek G, et al. Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease: the Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) study. Circulation 2002; 106: 933–8.
    OpenUrlAbstract/FREE Full Text
  26. ↵
    Suwa T, Hogg JC, Quinlan KB, Ohgami A, Vincent R, Van Eeden SF. Particulate air pollution induces progression of atherosclerosis. J Am Coll Cardiol 2002; 39: 935–42.
    OpenUrlCrossRefPubMedWeb of Science
  27. ↵
    Finkelstein MM, Verma DK, Sahai D, Stefov E. Ischemic heart disease mortality among heavy equipment operators. Am J Ind Med 2004; 46: 16–22.
    OpenUrlCrossRefPubMedWeb of Science
  28. ↵
    Doornaert B, Leblond V, Galiacy S, et al. Negative impact of DEP exposure on human airway epithelial cell adhesion, stiffness, and repair. Am J Physiol Lung Cell Mol Physiol 2003; 284: L119–32.
    OpenUrlAbstract/FREE Full Text
  29. ↵
    Inoue K, Takano H, Yanagisawa R, et al. Components of diesel exhaust particles differentially affect lung expression of cyclooxygenase-2 related to bacterial endotoxin. J Appl Toxicol 2004; 24: 415–8.
    OpenUrlCrossRefPubMedWeb of Science
  30. ↵
    Sivaloganathan S. Death from diesel fumes. J Clin Forensic Med 1998; 5: 138–9.
    OpenUrlPubMed
  31. ↵
    Proietti L, Spicuzza L, Polosa R. Urban air pollution at the crossroads of the allergic pandemic. Ann Ital Med Int 2003; 18: 64–72.
    OpenUrlPubMed
  32. Takizawa H. Diesel exhaust particles and their effect on induced cytokine expression in human bronchial epithelial cells. Curr Opin Allergy Clin Immunol 2004; 4: 355–9.
    OpenUrlCrossRefPubMed
  33. Holgate ST, Sandstrom T, Frew AJ, et al. Health effects of acute exposure to air pollution. Part I: healthy and asthmatic subjects exposed to diesel exhaust. Res Rep Health Eff Inst 2003; 112: 1–30.
    OpenUrlPubMed
  34. ↵
    Wilson AM, Wake CP, Kelly T, Salloway JC. Air pollution, weather, and respiratory emergency room visits in two northern New England cities: an ecological time-series study. Environ Res 2005; 97: 312–21.
    OpenUrlPubMedWeb of Science
  35. ↵
    Takano H, Yoshikawa T, Ichinose T, et al. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med 1997; 156: 36–42.
    OpenUrlCrossRefPubMedWeb of Science
  36. ↵
    Trasande L, Thurston GD. The role of air pollution in asthma and other pediatric morbidities. J Allergy Clin Immunol 2005; 115: 689–99.
    OpenUrlCrossRefPubMedWeb of Science
  37. ↵
    Diaz-Sanchez D, Penichet-Garcia M, Saxon A. Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity. J Allergy Clin Immunol 2000; 106: 1140–6.
    OpenUrlCrossRefPubMedWeb of Science
  38. ↵
    Groneberg-Kloft B, Kraus T, Mark A, Wagner U, Fischer A. Analysing the causes of chronic cough: relation to diesel exhaust, ozone, nitrogen oxides, sulphur oxides and other environmental factors. J Occup Med Toxicol 2006; 1: 6.
    OpenUrlCrossRefPubMed
  39. ↵
    Siegel PD, Saxena RK, Saxena QB, et al. Effect of diesel exhaust particulate (DEP) on immune responses: contributions of particulate versus organic soluble components. J Toxicol Environ Health A 2004; 67: 221–31.
    OpenUrlPubMedWeb of Science
  40. ↵
    Churg A, Brauer M, del Carmen Avila-Casado M, Fortoul TI, Wright JL. Chronic exposure to high levels of particulate air pollution and small airway remodeling. Environ Health Perspect 2003; 111: 714–8.
    OpenUrlPubMedWeb of Science
  41. ↵
    Sherwin RP, Richters V, Kraft P, Richters A. Centriacinar region inflammatory disease in young individuals: a comparative study of Miami and Los Angeles residents. Virchows Arch 2000; 437: 422–8.
    OpenUrlCrossRefPubMedWeb of Science
  42. ↵
    Gauderman WJ, Avol E, Gilliland F, et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med 2004; 351: 1057–67.
    OpenUrlCrossRefPubMedWeb of Science
  43. ↵
    Kulkarni N, Pierse N, Rushton L, Grigg, J. Carbon in airway macrophages and lung function in children. N Engl J Med 2006; 355: 21–30.
    OpenUrlCrossRefPubMed
  44. ↵
    Jorgensen H, Svensson A. Studies on pulmonary function and respiratory tract symptoms of workers in an iron ore mine where diesel trucks are used underground. J Occup Med 1970; 12: 348–54.
    OpenUrlPubMedWeb of Science
  45. ↵
    Wade JF, Newman LS. Diesel asthma, reactive airways disease following overexposure to locomotive exhaust. J Occup Med 1993; 35: 149–54.
    OpenUrlCrossRefPubMedWeb of Science
  46. ↵
    Dybdahl M, Risom L, Bornholdt J, Autrup H, Loft S, Wallin H. Inflammatory and genotoxic effects of diesel particles in vitro and in vivo. Mutat Res 2004; 562: 119–31.
    OpenUrlPubMedWeb of Science
  47. ↵
    Li N, Nel AE. The cellular impacts of diesel exhaust particles: beyond inflammation and death. Eur Respir J 2006; 27: 667–8.
    OpenUrlFREE Full Text
  48. ↵
    Garshick E, Laden F, Hart JE, et al. Lung cancer in railroad workers exposed to diesel exhaust. Environ Health Perspect. 2004; 112: 1539–43.
    OpenUrlPubMedWeb of Science
  49. ↵
    Jarvholm B, Silverman D. Lung cancer in heavy equipment operators and truck drivers with diesel exhaust exposure in the construction industry. Occup Environ Med 2003; 60: 516–20.
    OpenUrlAbstract/FREE Full Text
  50. ↵
    Parent ME, Rousseau MC, Boffetta P, Cohen A, Siemiatycki J. Exposure to diesel and gasoline engine emissions and the risk of lung cancer. Am J Epidemiol 2007; 165: 53–62.
    OpenUrlAbstract/FREE Full Text
  51. ↵
    Gustavsson P, Evanoff B, Hogstedt C. Increased risk of esophageal cancer among workers exposed to combustion products. Arch Environ Health 1993; 48: 243–5.
    OpenUrlPubMedWeb of Science
  52. ↵
    Guo J, Kauppinen T, Kyyronen P, Heikkila P, Lindbohm ML, Pukkala E. Risk of esophageal, ovarian, testicular, kidney and bladder cancers and leukemia among Finnish workers exposed to diesel or gasoline engine exhaust. Int J Cancer 2004; 111: 286–92.
    OpenUrlCrossRefPubMedWeb of Science
  53. ↵
    Lee WJ, Baris D, Jarvholm B, Silverman DT, Bergdahl IA, Blair A. Multiple myeloma and diesel and other occupational exposures in Swedish construction workers. Int J Cancer 2003; 107: 134–8.
    OpenUrlCrossRefPubMedWeb of Science
  54. ↵
    Brook RD, Brook JR, Urch B, et al. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 2002; 105: 1534–6.
    OpenUrlAbstract/FREE Full Text
  55. Ibald-Mulli A, Stieber J, Wichmann HE, Koenig W, Peters A. Effects of air pollution on blood pressure: a population-based approach. Am J Public Health 2001; 91: 571–7.
    OpenUrlCrossRefPubMedWeb of Science
  56. de Paula Santos U, Braga AL, Giorgi DM, et al. Effects of air pollution on blood pressure and heart rate variability: a panel study of vehicular traffic controllers in the city of Sao Paulo, Brazil. Eur Heart J 2005; 26: 193–200.
    OpenUrlAbstract/FREE Full Text
  57. Zanobetti A, Canner MJ, Stone PH, et al. Ambient pollution and blood pressure in cardiac rehabilitation patients Circulation 2004; 110: 2184–9.
    OpenUrlAbstract/FREE Full Text
  58. ↵
    Mills NL, Tornqvist H, Robinson SD, et al. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 2005; 112: 3930–6.
    OpenUrlAbstract/FREE Full Text
  59. ↵
    Block ML, Wu X, Pei Z, et al. Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase. FASEB J 2004; 18: 1618–20.
    OpenUrlAbstract/FREE Full Text
  60. ↵
    Calderon-Garciduenas L, Reed W, Maronpot R, et al. Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution. Toxicol Pathol 2004; 32: 650–8.
    OpenUrlCrossRefPubMedWeb of Science
  61. ↵
    Margai F, Henry N. A community-based assessment of learning disabilities using environmental and contextual risk factors. Soc Sci Med 2003; 56: 1073–85.
    OpenUrlPubMed
  62. ↵
    Kilburn KH. Effects of diesel exhaust on neurobehavioral and pulmonary functions. Arch Environ Health 2000; 55: 11–7.
    OpenUrlPubMed
  63. ↵
    Kim JJ. American Academy of Pediatrics Committee on Environmental Health. Ambient air pollution: health hazards to children. Pediatrics 2004; 114: 1699–707.
    OpenUrlAbstract/FREE Full Text
  64. Glinianaia SV, Rankin J, Bell R, Pless-Mulloli T, Howel D. Does particulate air pollution contribute to infant death? A systematic review. Environ Health Perspect 2004; 112: 1365–71.
    OpenUrlCrossRefPubMedWeb of Science
  65. Parker JD, Woodruff TJ, Basu R, Schoendorf KC. Air pollution and birth weight among term infants in California. Pediatrics 2005; 115: 121–8.
    OpenUrlAbstract/FREE Full Text
  66. Dolk H, Vrijheid M. The impact of environmental pollution on congenital anomalies. Br Med Bull 2003; 68: 25–45.
    OpenUrlAbstract/FREE Full Text
  67. ↵
    Watanabe N. Decreased number of sperms and Sertoli cells in mature rats exposed to diesel exhaust as fetuses. Toxicol Lett 2005; 155: 51–8.
    OpenUrlPubMed
  68. ↵
    Taneda S, Mori Y, Kamata K, et al. Estrogenic and anti-androgenic activity of nitrophenols in diesel exhaust particles (DEP). Biol Pharm Bull 2004; 27: 835–7.
    OpenUrlCrossRefPubMed
  69. ↵
    Fredricsson B, Moller L, Pousette A, Westerholm R. Human sperm motility is affected by plasticizers and diesel particle extracts. Pharmacol Toxicol 1993; 72: 128–33.
    OpenUrlCrossRefPubMedWeb of Science
  70. ↵
    Li C, Taneda S, Suzuki AK, Furuta C, Watanabe G, Taya K. Estrogenic and anti-androgenic activities of 4-nitrophenol in diesel exhaust particles. Toxicol Appl Pharmacol 2006; 217: 1–6.
    OpenUrlCrossRefPubMedWeb of Science
  71. ↵
    Schaeffer AR. Past and future considerations for heavy duty diesel engine emissions. Environ Health Perspect 2004; 112: A727–8.
    OpenUrlPubMed
  72. ↵
    Lanni T. Fine urban and precursor emissions control for diesel urban transit buses. Environ Pollut 2003; 123: 427–37.
    OpenUrlPubMed
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The Journal of the American Board of Family Medicine: 21 (1)
The Journal of the American Board of Family Medicine
Vol. 21, Issue 1
January-February 2008
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The Toxicity of Diesel Exhaust: Implications for Primary Care
Irina N. Krivoshto, John R. Richards, Timothy E. Albertson, Robert W. Derlet
The Journal of the American Board of Family Medicine Jan 2008, 21 (1) 55-62; DOI: 10.3122/jabfm.2008.01.070139

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The Toxicity of Diesel Exhaust: Implications for Primary Care
Irina N. Krivoshto, John R. Richards, Timothy E. Albertson, Robert W. Derlet
The Journal of the American Board of Family Medicine Jan 2008, 21 (1) 55-62; DOI: 10.3122/jabfm.2008.01.070139
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