Brief ReportBrief Report
Valproate-associated Hyperammonemic Encephalopathy
Jim Wadzinski, Ronald Franks, David Roane and Max Bayard
The Journal of the American Board of Family
Medicine September 2007, 20 (5) 499-502; DOI: https://doi.org/10.3122/jabfm.2007.05.070062
Jim Wadzinski
MD
Ronald Franks
MD
David Roane
PhD

References
- ↵Gerstner T, Buesing D, Longin E, et al. Valproic acid induced encephalopathy–19 new cases in Germany from 1994 to 2003–a side effect associated to VPA-therapy not only in young children. Seizure 2006; 15: 443–8.
- ↵
- ↵Marescaux C, Warter JM, Micheletti G, Rumbach L, Coquillat G, Kurtz D. Stuporous episodes during treatment with sodium valproate: report of seven cases. Epilepsia 1982; 23: 297–305.
- ↵Triggs WJ, Gilmore RL, Millington DS, Cibula J, Bunch TS, Harman E. Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure. Int J Clin Pharmacol Ther 1997; 35: 353–6.
- ↵Murphy JV, Marquardt K. Asymptomatic hyperammonemia in patients receiving valproic acid. Arch Neurol 1982; 39: 591–2.
- ↵Hamer HM, Knake S, Schomburg U, Rosenow F. Valproate-induced hyperammonemic encephalopathy in the presence of topiramate. Neurology 2000; 54: 230–2.
- ↵
- ↵Ohtani Y, Endo F, Matsuda I. Carnitine deficiency and hyperammonemia associated with valproic acid therapy. J Pediatr 1982; 101: 782–5.
- ↵Raskind JY, El-Chaar GM. The role of carnitine supplementation during valproic acid therapy. Ann Pharmacother 2000; 34: 630–8.
- ↵Bohan TP, Helton E, McDonald I, et al. Effect of L-carnitine treatment for valproate-induced hepatotoxicity. Neurology 2001; 56: 1405–9.
- ↵
- ↵LoVecchio F, Shriki J, Samaddar R. L-carnitine was safely administered in the setting of valproate toxicity. Am J Emerg Med 2005; 23: 321–2.
- ↵Verrotti A, Trotta D, Morgese G, Chiarelli F. Valproate-induced hyperammonemic encephalopathy. Metab Brain Dis 2002; 17: 367–73.
- ↵Camina MF, Rozas I, Castro-Gago M, Paz JM, Alonso C, Rodriguez-Segade S. Alteration of renal carnitine metabolism by anticonvulsant treatment. Neurology 1991; 41: 1444–8.
- ↵Coude FX, Grimber G, Parvy P, Rabier D, Petit F. Inhibition of ureagenesis by valproate in rat hepatocytes. Role of N-acetylglutamate and acetyl-CoA. Biochem J 1983; 216: 233–6.
- ↵Oechsner M, Steen C, Sturenburg HJ, Kohlschutter A. Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency. J Neurol Neurosurg Psychiatry 1998; 64: 680–2.
- ↵Vossler DG, Wilensky AJ, Cawthon DF, et al. Serum and CSF glutamine levels in valproate-related hyperammonemic encephalopathy. Epilepsia 2002; 43: 154–9.
- ↵
In this issue
The Journal of the American Board of Family
Medicine
Vol. 20, Issue 5
September-October 2007
Valproate-associated Hyperammonemic Encephalopathy
Jim Wadzinski, Ronald Franks, David Roane, Max Bayard
The Journal of the American Board of Family
Medicine Sep 2007, 20 (5) 499-502; DOI: 10.3122/jabfm.2007.05.070062
Related Articles
- No related articles found.