Skip to main content

Main menu

  • HOME
  • ARTICLES
    • Current Issue
    • Abstracts In Press
    • Archives
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • Other Publications
    • abfm

User menu

Search

  • Advanced search
American Board of Family Medicine
  • Other Publications
    • abfm
American Board of Family Medicine

American Board of Family Medicine

Advanced Search

  • HOME
  • ARTICLES
    • Current Issue
    • Abstracts In Press
    • Archives
    • Special Issue Archive
    • Subject Collections
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
    • Editors' Blog
  • CLASSIFIEDS
  • JABFM on Bluesky
  • JABFM On Facebook
  • JABFM On Twitter
  • JABFM On YouTube
Brief ReportBrief Report

Valproate-associated Hyperammonemic Encephalopathy

Jim Wadzinski, Ronald Franks, David Roane and Max Bayard
The Journal of the American Board of Family Medicine September 2007, 20 (5) 499-502; DOI: https://doi.org/10.3122/jabfm.2007.05.070062
Jim Wadzinski
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ronald Franks
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Roane
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Max Bayard
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. ↵
    Gerstner T, Buesing D, Longin E, et al. Valproic acid induced encephalopathy–19 new cases in Germany from 1994 to 2003–a side effect associated to VPA-therapy not only in young children. Seizure 2006; 15: 443–8.
    OpenUrlCrossRefPubMedWeb of Science
  2. ↵
    Yehya N, Saldarini CT, Koski ME, Davanzo P. Valproate-induced hyperammonemic encephalopathy. J Am Acad Child Adolesc Psychiatry 2004; 43: 926–7.
    OpenUrlCrossRefPubMed
  3. ↵
    Marescaux C, Warter JM, Micheletti G, Rumbach L, Coquillat G, Kurtz D. Stuporous episodes during treatment with sodium valproate: report of seven cases. Epilepsia 1982; 23: 297–305.
    OpenUrlPubMedWeb of Science
  4. ↵
    Triggs WJ, Gilmore RL, Millington DS, Cibula J, Bunch TS, Harman E. Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure. Int J Clin Pharmacol Ther 1997; 35: 353–6.
    OpenUrlPubMedWeb of Science
  5. ↵
    Murphy JV, Marquardt K. Asymptomatic hyperammonemia in patients receiving valproic acid. Arch Neurol 1982; 39: 591–2.
    OpenUrlCrossRefPubMedWeb of Science
  6. ↵
    Hamer HM, Knake S, Schomburg U, Rosenow F. Valproate-induced hyperammonemic encephalopathy in the presence of topiramate. Neurology 2000; 54: 230–2.
    OpenUrlAbstract/FREE Full Text
  7. ↵
    Laub MC, Paetzke-Brunner I, Jaeger G. Serum carnitine during valproic acid therapy. Epilepsia 1986; 27: 559–62.
    OpenUrlCrossRefPubMed
  8. ↵
    Ohtani Y, Endo F, Matsuda I. Carnitine deficiency and hyperammonemia associated with valproic acid therapy. J Pediatr 1982; 101: 782–5.
    OpenUrlCrossRefPubMedWeb of Science
  9. ↵
    Raskind JY, El-Chaar GM. The role of carnitine supplementation during valproic acid therapy. Ann Pharmacother 2000; 34: 630–8.
    OpenUrlAbstract/FREE Full Text
  10. ↵
    Bohan TP, Helton E, McDonald I, et al. Effect of L-carnitine treatment for valproate-induced hepatotoxicity. Neurology 2001; 56: 1405–9.
    OpenUrlAbstract/FREE Full Text
  11. ↵
    Bohles H, Sewell AC, Wenzel D. The effect of carnitine supplementation in valproate-induced hyperammonaemia. Acta Paediatr 1996; 85: 446–9.
    OpenUrlCrossRefPubMed
  12. ↵
    LoVecchio F, Shriki J, Samaddar R. L-carnitine was safely administered in the setting of valproate toxicity. Am J Emerg Med 2005; 23: 321–2.
    OpenUrlCrossRefPubMedWeb of Science
  13. ↵
    Verrotti A, Trotta D, Morgese G, Chiarelli F. Valproate-induced hyperammonemic encephalopathy. Metab Brain Dis 2002; 17: 367–73.
    OpenUrlCrossRefPubMedWeb of Science
  14. ↵
    Camina MF, Rozas I, Castro-Gago M, Paz JM, Alonso C, Rodriguez-Segade S. Alteration of renal carnitine metabolism by anticonvulsant treatment. Neurology 1991; 41: 1444–8.
    OpenUrlAbstract/FREE Full Text
  15. ↵
    Coude FX, Grimber G, Parvy P, Rabier D, Petit F. Inhibition of ureagenesis by valproate in rat hepatocytes. Role of N-acetylglutamate and acetyl-CoA. Biochem J 1983; 216: 233–6.
    OpenUrlAbstract/FREE Full Text
  16. ↵
    Oechsner M, Steen C, Sturenburg HJ, Kohlschutter A. Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency. J Neurol Neurosurg Psychiatry 1998; 64: 680–2.
    OpenUrlAbstract/FREE Full Text
  17. ↵
    Vossler DG, Wilensky AJ, Cawthon DF, et al. Serum and CSF glutamine levels in valproate-related hyperammonemic encephalopathy. Epilepsia 2002; 43: 154–9.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    Brusilow SW, Maestri NE. Urea cycle disorders: diagnosis, pathophysiology, and therapy. Adv Pediatr 1996; 43: 127–70.
    OpenUrlPubMed
PreviousNext
Back to top

In this issue

The Journal of the American Board of Family Medicine: 20 (5)
The Journal of the American Board of Family Medicine
Vol. 20, Issue 5
September-October 2007
  • Table of Contents
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Board of Family Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Valproate-associated Hyperammonemic Encephalopathy
(Your Name) has sent you a message from American Board of Family Medicine
(Your Name) thought you would like to see the American Board of Family Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
2 + 1 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Valproate-associated Hyperammonemic Encephalopathy
Jim Wadzinski, Ronald Franks, David Roane, Max Bayard
The Journal of the American Board of Family Medicine Sep 2007, 20 (5) 499-502; DOI: 10.3122/jabfm.2007.05.070062

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Valproate-associated Hyperammonemic Encephalopathy
Jim Wadzinski, Ronald Franks, David Roane, Max Bayard
The Journal of the American Board of Family Medicine Sep 2007, 20 (5) 499-502; DOI: 10.3122/jabfm.2007.05.070062
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Case Reports
    • Conclusion
    • Notes
    • References
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Non-cirrhotic hyperammonaemia: are we missing the diagnosis?
  • Effects of Edaravone on Cardiac Damage in Valproic Acid Induced Toxicity
  • Carbamazepine-induced hyperammonemia
  • Google Scholar

More in this TOC Section

  • Association of Social Needs with Diabetes Outcomes in an Older Population
  • Insurance Instability Among Community-Based Health Center Patients with Diabetes Post-Affordable Care Act Medicaid Expansion
  • Factors Influencing Changing Scopes of Practice Among Contemporary Graduates of the Nation’s Largest Family Medicine Residency
Show more Brief Reports

Similar Articles

Navigate

  • Home
  • Current Issue
  • Past Issues

Authors & Reviewers

  • Info For Authors
  • Info For Reviewers
  • Submit A Manuscript/Review

Other Services

  • Get Email Alerts
  • Classifieds
  • Reprints and Permissions

Other Resources

  • Forms
  • Contact Us
  • ABFM News

© 2025 American Board of Family Medicine

Powered by HighWire