Review ArticleClinical Review

Basal Insulin Therapy in Type 2 Diabetes

M. Angelyn Bethel and Mark N. Feinglos
The Journal of the American Board of Family Practice May 2005, 18 (3) 199-204; DOI: https://doi.org/10.3122/jabfm.18.3.199

Article Figures & Data

Figures

  • Figure 1.
    Figure 1.

    Idealized pattern of insulin secretion for a healthy individual who has consumed 3 standard meals: breakfast (B), lunch (L), and dinner (D). HS, bedtime.6

  • Figure 2.
    Figure 2.

    Time-activity profiles (hourly mean values) of insulin glargine and NPH insulin in patients with type 2 diabetes.24

Tables

  • Table 1.

    Key Pharmacodynamic Properties for Different Insulin Preparations6,28

    Insulin PreparationOnset of ActionPeak Action (hours)Duration of Action (hours)
    Lispro5 to 15 minutes1 to 23 to 4
    Aspart5 to 15 minutes1 to 23 to 4
    Regular30 to 60 minutes2 to 46 to 8
    NPH1 to 3 hours5 to 713 to 16
    Lente1 to 3 hours4 to 813 to 20
    Ultralente2 to 4 hours8 to 14<20
    Glargine2 to 4 hoursFlat>24

    • NPH, neutral protamine Hagedorn.

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