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Research ArticleOriginal Article

Rate of Breast Cancer Diagnoses among Postmenopausal Women with Self-Reported Breast Symptoms

Erin J. Aiello, Diana S. M. Buist, Emily White, Deborah Seger and Stephen H. Taplin
The Journal of the American Board of Family Practice November 2004, 17 (6) 408-415; DOI: https://doi.org/10.3122/jabfm.17.6.408
Erin J. Aiello
MPH
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Diana S. M. Buist
PhD, MPH
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Emily White
PhD
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Deborah Seger
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Stephen H. Taplin
MD, MPH
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  • Article
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Article Figures & Data

Tables

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    Table 1.

    Characteristics of 57,681 GHC Women Who Obtained Diagnostic and Screening Mammograms between 1996 and 2001

    Diagnostic exams (N = 13,524 exams)Screening exams (N = 110,323 exams)
    Number of women11,33446,347
    MeanSDMeanSD
    Age61.311.062.910.9
    BMI (kg/m2)27.26.327.26.4
    N%N%
    Family history of breast cancer5,11237.840,37836.6
    Hormone therapy use
        Never1,30021.632,90632.1
        Former user2,23137.119,44619.0
        Current user2,47941.250,20949.0
        Unknown7,5147,762
    Previous biopsy3,51326.022,60320.5
    Reported any symptom4,27531.65,1774.7
    Diagnosed with breast cancer*6664.97230.7
    Prior mammogram history†
        No mammogram within 3 years5208.87,53121.5
        Mammogram without symptoms4,64578.325,79273.7
        Mammogram with symptoms76913.01,6824.8
    • * Women were followed-up for 12 months after each exam for a breast cancer diagnosis.

    • † Includes only women with exams from 1999 to 2001. N = 5,934 with diagnostic exams and 35,005 with screening exams.

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    Table 2.

    Breast Cancer Rates* and Adjusted Odds Ratios† (OR) with 95% Confidence Intervals (CI) for Breast Cancer Associated with Breast Symptoms

    Symptom‡Diagnostic ExamsScreening Exams
    NBreast CancerOR (95% CI)NBreast CancerOR (95% CI)
    NRateNRate
    None9,249383411.0105,14665661.0
    Any4,275283662.0 (1.6, 2.3)5,17767132.1 (1.6, 2.7)
    Lump2,745229832.8 (2.3, 3.4)1,74038223.6 (2.6, 5.0)
    Nipple discharge47025531.5 (1.0, 2.3)87310111.8 (1.0, 3.4)
    Pain28715521.4 (0.8, 2.4)694691.5 (0.7, 3.4)
    Other1,40058411.2 (0.9, 1.6)2,6722071.2 (0.8, 1.9)
    • * Rate of breast cancer diagnoses per 1000 women per year.

    • † Adjusted for age, body mass index, family history of breast cancer, previous breast biopsy, and hormone therapy use.

    • ‡ Symptom categories are not mutually exclusive.

    • View popup
    Table 3.

    Breast Cancer Rates* among 40,939 Symptomatic and Asymptomatic Women Stratified by Diagnostic and Screening Exams, Prior Mammogram History, and Symptom History†

    Symptom‡Diagnostic Exams (N = 5,934)Screening Exams (N = 35,005)
    No Prior Exam (N = 520)Prior Exam with No Symptoms (N = 4,645)Prior Exam with Symptoms† (N = 769)No Prior Exam (N = 7,531)Prior Exam with No Symptoms (N = 25,792)Prior Exam with Symptoms† (N = 1,682)
    NBreast Cancer Rate*NBreast Cancer Rate*NBreast Cancer Rate*NBreast Cancer Rate*NBreast Cancer Rate*NBreast Cancer Rate*
    None132153,88545248617,142324,71421,3945
    Any3881117601015214838931,078928810
    Lump24313650413329461104102363410419
    Nipple discharge441827242653169014676216
    Pain481258857129012004040790
    Other138872355517934194057821150
    • * Rate of breast cancer diagnoses per 1000 women per year.

    • † Symptoms reported at prior examination could have been any symptoms.

    • ‡ Symptom categories are not mutually exclusive.

    • View popup
    Table 4.

    Adjusted* Odds Ratios (OR) with 95% Confidence Intervals (CI) for Breast Cancer among Symptomatic Women Compared with Asymptomatic Women Stratified by Diagnostic and Screening Exams, Prior Screening History, and Symptom History†

    Symptom‡Diagnostic ExamsScreening Exams
    No Prior ExamPrior Exam with No SymptomsPrior Exam with Symptoms†No Prior ExamPrior Exam with No SymptomsPrior Exam with Symptoms†
    Any2.7 (2.0, 37.1)2.9 (1.9, 4.3)0.9 (0.4, 1.6)1.0 (0.1, 7.4)4.5 (2.3, 8.9)2.1 (0.5, 8.3)
    Lump12.2 (2.8, 53.5)4.1 (2.7, 6.2)1.2 (0.6, 2.5)3.5 (0.5, 27.0)17.2 (8.0, 37.1)3.9 (0.8, 20.0)
    Nipple discharge13.3 (2.6, 66.9)1.0 (0.3, 3.4)0.5 (0.1, 2.5)3.0 (0.4, 22.1)3.8 (0.5, 33.0)
    Pain8.9 (1.6, 50.0)1.5 (0.6, 4.0)
    Other6.4 (1.4, 29.7)1.5 (0.8, 2.9)0.6 (0.2, 1.6)0.8 (0.1, 6.0)
    • * Adjusted for age, body mass index, family history of breast cancer, previous breast biopsy, and hormone therapy use.

    • † Symptoms reported at previous exam could have been any symptom.

    • ‡ Symptom categories are not mutually exclusive.

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The Journal of the American Board of Family Practice: 17 (6)
The Journal of the American Board of Family Practice
Vol. 17, Issue 6
1 Nov 2004
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Rate of Breast Cancer Diagnoses among Postmenopausal Women with Self-Reported Breast Symptoms
Erin J. Aiello, Diana S. M. Buist, Emily White, Deborah Seger, Stephen H. Taplin
The Journal of the American Board of Family Practice Nov 2004, 17 (6) 408-415; DOI: 10.3122/jabfm.17.6.408

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Rate of Breast Cancer Diagnoses among Postmenopausal Women with Self-Reported Breast Symptoms
Erin J. Aiello, Diana S. M. Buist, Emily White, Deborah Seger, Stephen H. Taplin
The Journal of the American Board of Family Practice Nov 2004, 17 (6) 408-415; DOI: 10.3122/jabfm.17.6.408
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